Collection: Insulin Resistance / PCOS

Clinical Pearl

  • People with pre-diabetes or insulin resistance also can have low or normal blood sugars, if their high circulating insulin levels are further challenged by a prolonged period of fasting or dietary restriction.
  • Red Blood Cell (RBC) agglutination (stuck together) has been consistently associated with insulin resistance.
  • Insulin Resistance deprives all parts of the body of glucose and oxygen. Both of which are delivered through the blood.

Symptoms of Insulin Resistance

  • Fatigue. Sometimes the fatigue is physical, but often it is mental.
    • Muscles, nerves and all other parts of the body require oxygen and glucose to function efficiently. Insulin Resistance deprives all of them of the necessary oxygen and glucose.
    • RBC agglutination slows blood flow to the muscles, nerves and all parts of the body. Further depriving all of them of oxygen and glucose.
  • Brain fogginess and inability to focus.
    • Brain requires oxygen and glucose to function efficiently. Insulin Resistance deprives the brain of the necessary oxygen and glucose.
    • RBC agglutination slows blood flow to the brain. Further depriving the brain of oxygen and glucose.
  • Depression.
    • Brain requires oxygen and glucose to function efficiently. Insulin Resistance deprives the brain of the necessary oxygen and glucose.
    • RBC agglutination slows blood flow to the brain. Further depriving the brain of oxygen and glucose.
  • Nerve Pain – Blood / Nerve Reciprocity
    • Nerves and all other parts of the body require oxygen and glucose to function efficiently. Insulin Resistance deprives all of them of the necessary oxygen and glucose.
    • All nerves depend wholly upon the arterial system for their oxygen and glucose and the quality of their function, such as sensation, signal transmission and motion.
    • A loss of blood flow results in nerve cell deterioration and ultimately in nerve death starting within minutes. A deteriorating nerve send pain signals to the brain.
    • RBC agglutination slows blood flow to the nerves and all parts of the body.
  • High blood sugar. Mild, brief periods of low blood sugar are normal during the day, especially if meals are not eaten on a regular schedule. But prolonged hyperglycemia with some of the symptoms listed here, especially physical and mental fatigue, are not normal.
  • Feeling agitated, jittery, moody, nauseated, or having a headache is common in Insulin Resistance, without immediate relief once food is eaten.
  • Intestinal bloating. Most intestinal gas is produced from food fermenting and putrefying due to inadequate production of digestive chemistry.
  • Insulin Resistance sufferers who eat carbohydrates suffer from gas, lots of it.
  • Sleepiness. Many people with Insulin Resistance get sleepy immediately after eating a meal exceeding their Carbohydrate Tolerance. Body is going into power-saver mode like your electronic device.
  • Fatigue after meals, craving sugar after meals, must have dessert:
    • Cut back on carbs until you are no longer sleepy after meals and/or do not crave sugar after eating.
  • Hepatic Portal Hypertension
    • Insulin resistance (IR) is an important driver for the development of portal hypertension and nonalcoholic fatty liver.[i]
    • Espohageal varicies,[ii],[iii],[iv] hemorrhoids
  • Nonalcoholic Fatty Liver (NAFL)
    • A condition marked by elevated liver enzymes, abnormally high levels of fat in the liver, and enlargement of the organ, the severity of nonalcoholic fatty liver disease increases with obesity and abdominal fat and may develop as a result of Insulin Resistance.
  • Obstructive Sleep Apnea
    • Sleep apnea is a breathing disorder in which you stop breathing for very short periods of time while sleeping.
  • Weight Gain - fat storage, difficulty losing weight. The fat in IR is generally stored around the midsection in both males and females.
  • Dyslipidemia - Increased cholesterol and triglycerides.
    • RBC Agglutination causes RBCs to shed oxygen. Free oxygen becomes destructive Reactive Oxygen Species (free-radicals) that damage interior of blood vessels. Cholesterol is used to spackle over the damaged areas.
    • When triglycerides are equal to or greater than cholesterol suspect Diabetes.
  • Cardiovascular disease
    • RBC Agglutination causes RBCs to shed oxygen. Especially in turbulent areas, i.e. heart blood vessels. Free oxygen becomes destructive Reactive Oxygen Species (free-radicals) that damage interior of blood vessels. Cholesterol is used to spackle over the damaged areas.
  • Hypertension - Increased blood pressure.
    • It is a fact that most people with hypertension have too much insulin and are Insulin Resistant. It is often possible to show a direct relationship between insulin resistance and blood pressure: as insulin levels elevate, so does blood pressure.
  • Low Thyroid
    • Everything the body does is defensive in nature.
    • Supply vs. Demand
      • Thyroid Hormones stimulate the metabolic rate.
      • Insulin Resistance slows the metabolic rate.
      • Thyroid will slow production of thyroid hormones to compensate for insulin resistance.
    • Reduced levels of oxidative stress accompany hypothyroidism (low thyroid)
    • Hypothyroidism reduces production of reactive oxygen species generation, lipid peroxidation, and NAFL.

Symptoms of Red Blood Cell Aggregation

  • Fatigue
  • Brain fogginess and inability to focus
  • Nerve pain
  • Cold hands and feet
  • Numbness and tingling in arms and legs
  • Muscle cramping


[i] Erice E, Llop E, Berzigotti A, Abraldes JG, Conget I, Seijo S, et al. Insulin resistance in patients with cirrhosis and portal hypertension. American journal of physiology Gastrointestinal and liver physiology. 2012;302(12):G1458–65.

[ii] Marcos Pasarín, Juan G Abraldes, Eleonora Liguori, Beverley Kok and Vincenzo La Mura, Intrahepatic vascular changes in non-alcoholic fatty liver disease: Potential role of insulin-resistance and endothelial dysfunction, World Journal of Gastroenterology, 10.3748/wjg.v23.i37.6777, 23, 37, (6777-6787), (2017).

[iii] Delphine Degré, Thierry Gustot, Ariane Gerkens, Nathalie Boon, Jonas Schreiber, Antonia Lepida, Thomas Sersté, Pierre Deltenre, Jacques Devière, Eric Trépo and Christophe Moreno, Insulin resistance is associated with esophageal varices in alcoholic liver disease patients, European Journal of Gastroenterology & Hepatology, 10.1097/MEG.0000000000000627, 28, 7, (792-796), (2016).

[iv] Ying Li, Gao Yang, Jinwei Qiang, Songqi Cai and Hao Zhou, Incidence of insulin resistance and diabetes in patients with portosystemic shunts without liver dysfunction, Journal of International Medical Research, 10.1177/0300060516659392, 44, 5, (1040-1048), (2016).

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