What are Forbidden Cytokines?

Forbidden Cytokines and Autoimmunity

Chronic – long term immune stimulation drive distinct Th1 and Th2 cells to release ‘‘FORBIDDEN’’ cytokine secretions[viii]: secretion of Th2 cytokines from a Th1 T cells and vice versa. Such a phenomenon cannot be induced by classical antigenic stimulation. The immune cells become confused and respond inappropriately to immune messengers – producing confusing symptoms and responses to treatment.

T-cells secrete various cytokines through which they affect a broad spectrum of normal and pathological immune processes. Cytokine secretion by helper T cells is particularly important in autoimmunity[i] because chronic autoimmune diseases, such as Hashimoto’s Thyroiditis, Multiple Sclerosis, Type 1 Diabetes, and Rheumatoid Arthritis are predominantly caused by Th1 cells. Th2 cells can antagonize Th1 functions[ii] and in numerous autoimmune conditions prevent and/or cure autoimmune diseases.

All Components of the NEI Supersystem – including Cytokines and Chemokines are Dose-Dependent

However, recent studies found exceptions to this rule, suggesting that the behavior of a given T cell population may be unpredictable in its cytokine secretion profile. For example, (i) Th2-type T cells can be not only inefficient suppressors of autoimmune conditions induced by Th1 cells,[iii] but can cause Autoimmune conditions;[iv] thus Th1 and Th2 cells can both promote autoimmune conditions; (ii) Th0-type T cells (producing both Th1 and Th2 cytokines) can stimulate autoimmune conditions and are able to instigate Autoimmune conditions;[v] and (iii) Th2-type T cells can induce pancreatitis and diabetes in immune-compromised nonobese individuals with blood sugar problems.[vi]

The cytokine secretion of the same T cell population is different in the lymph nodes (producing both Th1 and Th2 cytokines) than in the central nervous system (CNS) environment (producing only Th1 cytokines). This observation suggests that within the CNS, specific factors (mainly IL-12 producing microglia acting as APCs, not neurons) can modulate the cytokine secretion of Tcells, can select Th1/Th2 pathway, and can control effector CD4+ T cell cytokine profile in Autoimmune conditions.[vii]

Four neuropeptides (NPs): somatostatin, calcitonin gene-related peptide, neuropeptide Y, and substance P, in the absence of any additional factors, directly induce a increased secretion of cytokines [interleukin 2 (IL-2), interferon-g, IL-4, and IL-10) from T cells. Furthermore, these NPs drive distinct Th1 and Th2 populations to a ‘‘FORBIDDEN’’ cytokine secretion[viii]: secretion of Th2 cytokines from a Th1 T cell line and vice versa. Such a phenomenon cannot be induced by classical antigenic stimulation.

The nervous system, through these NPs interacting with their specific T cell-expressed receptors, can lead to the secretion of both typical and atypical cytokines, leading to the breakdown of the commitment to a distinct Th phenotype, and a potentially altered function and destiny of T cells in vivo.

Nerve fibers that release NPs are widespread in the mammalian central and peripheral nervous systems, in certain endocrine tissues, and in all the primary and secondary lymphoid organs.[ix]

Inflammation Is An Immune Response

Inflammation is part of the non-specific immune response that occurs in reaction to any type of bodily injury. In some disorders, the inflammatory process − which under normal conditions is self-limiting − becomes continuous and chronic inflammatory diseases might develop subsequently.

How do they separate the Immune Response from Inflammation?

Today, very few health practitioners could tell you that inflammation is part of the nonspecific immune response that occurs in reaction to any type of bodily injury and that the cardinal signs of inflammation can be explained by increased blood flow, elevated cellular metabolism, vasodilatation, release of soluble mediators, extravasation of fluids and cellular influx. They would never associate inflammation with an immune response. An immune response in their world would be something that occurs only with bacteria or viruses.

Inflammation is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants,[1] and is a protective response involving immune cells, blood vessels, and cytokine / chemokine immune mediators. The function of inflammation is to eliminate the initial cause of cell injury, clear out dead or damaged cells and tissues damaged from the original insult and the inflammatory process, and initiate tissue repair.

Acute (Short-term) or Chronic (Long-term) Inflammation

Inflammation can be classified as either acute or chronic. Acute inflammation is the initial response of the body to harmful stimuli and is achieved by the increased movement of plasma and leukocytes (especially granulocytes) from the blood into the injured tissues. A series of biochemical events propagates and matures the inflammatory response, involving the local vascular system, the immune system, and various cells within the injured tissue. Prolonged inflammation, known as chronic inflammation, leads to a progressive shift in the type of cells present at the site of inflammation, such as mononuclear cells, and is characterized by simultaneous destruction and healing of the tissue from the inflammatory process. Over time the destruction will become greater than the healing of the tissue.

Continuous Inflammation = Continuous Immune Response

In some disorders the inflammatory process, which under normal conditions is self-limiting, becomes continuous and chronic inflammatory diseases develop subsequently. This inflammatory process is enhanced by the over-use of immune stimulating supplements, probiotics and bone broth.

Is the peer group always correct? You are not allowed to think differently from the group.

Chronic inflammation culminates in devastating events that can lead ultimately to major organ dysfunction due to abnormalities in tissue architecture after regeneration and replacement by non-functional fibrous tissue. Once this stage is reached, it becomes more difficult to reverse, it at all.

Inflammation is not a synonym for infection. Infection describes the interaction between the action of microbial invasion and the reaction of the body’s inflammatory response — the two components are considered together when discussing an infection, and the word is used to imply a microbial invasive cause for the observed inflammatory reaction. Inflammation on the other hand describes purely the body’s immunovascular response, whatever the cause may be.

Therapies developed against these illnesses are not foolproof, as when more than one factor comes into play, the number of interactions also raises exponentially.  We might well be standing before a family of very closely related diseases with ubiquitous symptoms common to all. Yet differing only due to very small changes at some point along the inflammatory cascade. The common denominator in these conditions is the immune system.

And so these Doctors Disputed loud and long Each in his own opinion Exceeding stiff and strong, Though each was partly in the right, And all were in the wrong! The Blind Men and the Elephant: 1865

Understanding the cell-signalling networks involved in chronic inflammation gives rise to new insight into how drugs target the immune system to suppress troublesome diseases, e.g. ‘old’ therapies such as glucocorticoid
and immunosuppressants work by suppressing the Th2 responses.

[1] Ferrero-Miliani L, Nielsen OH, Andersen PS, Girardin SE; Nielsen; Andersen; Girardin (February 2007). “Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation”. Clin. Exp. Immunol. 147

Living the Nocebo Effect

Disease Diagnosis are not Entities entering your body seeking to do you harm.

And so these Doctors Disputed Loud and Long, Each in his own opinion, Exceeding stiff and strong, Though each was partly in the right, And all were in the wrong! The Blind Men and the Elephant: 1865

Too many people convinced of the “Nocebo Effect” by Professional and Social Media Influencers are unable to see or experience any improvement.

What does “Better” mean to you? Are you on a never-ending-treatment-protocol? What happens if you stop it? If you get worse – You are not “Better”. You are dependent.

Define Better! What Does “BETTER” Mean To You?

Too many times patients get to a point of having to decide whether to be sick or no longer need treatment, decide to stay sick. Mostly due to their Social Media Support Group pulling them back into sickness.

Too many people are convinced by Professional or Social Media Influencers of the futility of health and the inevitability of sickness to support sales of their effectively-ineffective products and treatments.

I have a Positive Antibody Test Result?

Do you have Positive Antibody Test Results? Are you questioning the results? Are you feeling no different after months on your treatment regimen? Antibody testing is not as infallible as they are made out to be.

If the results of Antibody tests are tied only to symptoms, you are guaranteed to be diagnosed with whatever condition you are being tested for.

Fallibility of Antibody Testing

I first began to question antibody testing after working with a 16 year old cheerleader that would go violently manic after eating gluten. I am talking about call 911 – violently manic. How could that occur where the behavior and symptoms do not match the lab test?

16 year old Cheerleader would go violently manic after eating gluten. Serum (blood) test reported Zero IgA Gluten antibodies. Stool test IgA Gluten antibodies was 5.3 – equivocal. The IgAs are the same throughout the body. The problem is not in the lab tests. The problem lies in her immune systems inappropriate response.

My personal lab tests were the opposite of the Cheerleaders. My saliva IgA test results were positive. My stool IgA results showed my intestinal tract was producing very low quantities of IgAs.

My personal Gluten/gliadin IgA test results done a week apart. I experienced severe brain fog and dyslexia after eating gluten. That was then. Now am able to eat gluten without any symptoms.

My first thoughts were – maybe the saliva, serum and gut produce different types of IgAs. Not the case. IgAs are the same through out the body. My next question is how could be IgAs produced in different parts of the body be so vastly different in the body?

I spoke with the Professional Influencers, who promote Antibody testing. Their answers were to blame the lab tests. Okay??? If the lab tests are a problem. Why are you still using and promoting them in your classes? Foot steps. Click – phone disconnected.

Dogma of Antibody Testing.

Immune Responses cause Inflammation.
Abnormal or Positive Antibody results does not indicate an active Immune Response.

The current dogma is that Immune cells are stimulated by Antibodies. The Antibody tests are thought to be absolutely accurate and infallible. They believe as long as antibodies are present, the antibodies are constantly stimulating an immune response. They also are lead to believe the presence of antibodies are from an ongoing infection. Typically, IgG antibodies are produced in the first phase of immune responses. However, the immune response to IgA, IgG, and IgM declines or is terminated along the course of the disease in most patients. IgM antibodies are indicative of an ongoing immune response., This suggests that the antibody response eventually burns out. Studies have shown the detection of IgA and IgM antibodies in 62% and 61% of IgG antibodies have been found in autoimmune patients after 7 years.

36 year old woman told by MD, she needed MMR booster shot because her children are starting school.

This suggests that the antibody response eventually burns out.

The presence of TPO, TAA and Gluten antibodies does not indicate an active Hashimoto’s – Thyroid Immune Attack.

A resolution of the disease is not associated with a decrease in antibodies. Only those with a short disease duration are likely to experience a decrease in antibodies levels. For most autoimmune patients there is no significant change in antibody levels, However, patients with immune calming/quieting treatment, experienced a 20% decline in their antibody levels. Normalization in the levels of antibodies with treatment intervention occurs in less that 7% of patients. The success of clinical interventions in lowering antibody levels (and thus likely minimizing the pathogenic effects of autoantibody binding) appears to be dependent on disease duration. The association of shorter disease duration with greater declines in antibody levels is highly consistent with the growing body of evidence that shows improved clinical outcomes with earlier disease intervention in autoimmunity.,,

36 year old woman told by MD, she needed MMR booster shot because her children are starting school.

Approximately one-half of patients with Rheumatoid Arthritis had positive IgM-RF and/or antibodies on at least 1 occasion, almost 5 years prior to disease onset. More than 50% of autoimmune patients may have positive antibodies upwards of 13 years after disease resolution, regardless of treatment.

Do You Need More Examples Of Questionable Antibody Tests?

Most Doctors will blame the Laboratory Company. It is not the Laboratory Company. They are reporting accurate results for what they are testing. It is your “Immune System” that is the problem. Your Immune System is not just compromised. It is broken.

36 year old woman told by MD, she needed MMR booster shot because her children are starting school.

How many $$$thousands of Dollars are spent on Antibody testing. One patient that came to my office for help spent in excess of $4,500 in antibody lab testing. All of the results were “IN RANGE” negative.

MRT Cytokine test shows severe reactivity to yeast while Cyrex antibody test shows none.

Until the Immune System is calmed and quieted, antibody tests are pretty useless, confusing and frustrating. People are constantly changing their diet to comply with their food allergy test. Many tests results are over five years old. Many people have done multiple food allergy tests. Yet, the person is still attempting to comply dietarily with all of the tests results, while sliding down a slippery slope and nothing it working. So, they seek out another Diagnosis du jour. Never letting go of the old diagnosis or test result and incorporating the new.

The Immune System is dynamic and responses to food can change over time

Has anyone ever stopped to consider the Immune System is dynamic and responses to food can change over time? Food sensitivities/allergies are not permanent, forever and ever, written in stone.

MRT Cytokine test shows severe reactivity to millet, oats and rice while Cyrex antibody test shows none.

Whatever food you frequently consume to comply with avoiding your food sensitivity/allergy meals will become the new food sensitivity/allergy.

MRT Cytokine test shows reactivity to milk and dairy while Cyrex antibody test shows none.

I have not used a food allergy/sensitivity test for about 15 years. It is unlikely that I would recommend them as long as people are bringing these conflicting test results.

As a farmer, I question how tomatoes and other summer vegetables are “Fresh” when there is snow on the ground.

It is not the foods that are causing the problem. Except for lectins. Lectins are a problem. People are “eating only fresh”, “eating organic” foods that have been harvest when they were not ripe, gassed to prevent further ripening, stored in Atmosphere Controlled Storage for months or years, shipped to the wholesaler, gassed again to restart ripening, then put out in the “fresh produce” aisle. Yes, even at Whole Foods and Trader Joes. I know how you think!!!

Atmosphere Controlled Storage of “Fresh” produce allows them to be stored for months or years before being sold as “Fresh” produce.

I focus instead on restoring the production and sequencing of digestive chemistry. Lectins shut off the production of digestive chemistry to allow a viable seed to survive travel through the digestive tract. I choose to calm and quiet the Immune System. Why would I want to stimulate an out-of-control immune response.

No! Stimulating your immune system will not reset it back to normal when it is out-of-control, responding inappropriately.

Do you need help? Are you sick and tired of feeling sick and tired? Are you frustrated with your boiled chicken meals. Oh, by the way, that bone broth you are drinking may be causing part of your problems as it stimulate cytokine that do not need antibody to flair up.

A Medical View of the Coronavirus – Notes/Critique/Comments


Notes/Critique/Comments on the Podcast

3:14 Selenium levels

Selenium – decreases virus susceptibility. How much does one take?

Brazil Nuts – Strongest source 6-9 nuts / “Month”; during viral episodes – 6 per week. How many people are going to start pounding down Brazil Nuts? How will they feel from it?

I know how you all operate. You are not the first and will not be the last to over-indulge in a “good” thing.

Selenium Toxicity – nausea, abdominal pain. Sound a lot like virus/flu symptoms. Maybe those who are taking Selenium for the thyroid or hair loss are creating their ubiquitous symptoms.

11:17 facemask

Most helpful if your surrounded by people living in areas with cases reported. 

13.45 Hand sanitizer

Carry with you – Wipe things down.

14:26 Robust immune system

Recommends stimulating the immune system with Zinc, selenium, boost lymphocyte activity.  With all those recommendations from Professional and Social Media Influencers, Medical, Alternative and Functional providers all recommending boosting, stimulating and/or strengthening the immune system. Why are all these people following their recommendations having more and more immune challenges? (See 19:50 Increasing Immune Cells)

Suppression – poor diet, sugar

Colostrum – immune stimulator, works in gut (See 19:50 Increasing Immune Cells)

19:50 Increasing Immune Cells

Very few Healthcare providers ever consider or talk about Memory Cells and Naïve cells or the life cycle of immune cells. No mention was made in this podcast or by any professional or social media influencer. It is always just the collective “Immune System”.

CD 38 cells marker for the age of the immune system.

CD4 Old Programmed immune cell / CD8 New Naïve Un-programmed immune cell

CD4, CD8, CD38 tests only show the “NUMBER” of immune cells. These tests do not show if the immune cells are fatigued, dormant, working normal, aggravated, or over-stimulated.

The more helper cells the younger, more naive the immune cells. The older the immune system, they more the immune cells are running on previous programing and unable to respond to new threats. 

Our immune system has an incredible ability; it can remember infections it has already encountered, and when the body has another encounter with the invader, the response from the immune system is rapid and efficient. While some of the details of this process are understood, many questions remain and memory cells are rarely mentioned by healthcare providers. When in fact, some of the same immune cells that battle the original infection hang around, remaining alive for years. Those cells develop unique characteristics that enable them to spring into action if the invader returns.

It is critical to almost all functions of the immune response is the activation and programming of T cells from their naïve/resting state. A T cell that is capable of providing immune protection, first requires “activation” by the programing of the naïve T cell on what to attack.

Naïve immune cells must be programmed to new threats. That’s why they are called naïve. They have a lack of experience from previous exposure. They are rookie responders that must be told what their job is. As soon as they are programmed, their biologic clock starts ticking. Most Naïve immune cells are programmed to die so they do not continue the attack after the threat is gone.

Infections and vaccines stimulate the immune system, causing cells that have never been used, naïve cells, to start reproducing, generating a pool of cells that can fight invaders. Some will become Memory Cells. The memory cell pool shrinks over time, and long-term memory cells are created. They are meant to provide protection over a much longer period.

These cells are like veteran soldiers, camped in the blood and tissues where they have previously fought the battles, waiting for a virus or bacteria to show up. They are resting quietly, but they are deeply experienced, ready to spring into action and primed to respond wildly and attack aggressively if invaders return.

Constantly revving up the immune system fatigues the immune response, making it slow to respond when it is needed. 

Constant immune stimulation shrinks the memory cell pool, leaving the body vulnerable to invaders. Constant immune stimulation programs new naive immune cells to old threat information, reducing the number of naive immune cells available for programming to new invader threats.

Example: Person has old knee injury which damaged collagen. It is the immune systems duty to clean up the frayed collagen. Naive immune cells are programmed to remove frayed collagen bits and the knee injury is healed. Some of the programed naive cells become memory cells which respond quickly and aggressively to collagen bits. The same person reads on the internet how collagen is beneficial in the body and is constantly consuming collagen supplement. Plus, is taking immune stimulants. Immune stimulants make memory cells more hostile to collagen in the body where ever it is found throughout the entire body. The person wonders why they have Rheumatoid Arthritis.  

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089090/

https://www.labroots.com/trending/cell-and-molecular-biology/7665/understanding-memory-immune-system

https://www.ncbi.nlm.nih.gov/m/pubmed/32133832/?fbclid=IwAR2Nnz7nNHS_bA6oP7lmz5Uh05nsEx3mCZd3lEATTfZudbfLcHBs2h5Kq9Q

21:50 After age 65 living on residual immune system. 

At that age, most have a history of repeatedly taking immune suppressing drugs. Depletion of memory cells and/or memory cells have been programmed not to respond.

23:46 Jumps around all the barriers.

There is a for lack of better words and energy that spreads amongst the population where those not exposed start developing an immune response. This allow survival of the species. 

Hundredth Monkey Effect

The hundredth monkey effect is a phenomenon in which a new behavior or idea is said to spread rapidly by unexplained means from one group to all related groups once a critical number of members of one group exhibit the new behavior or acknowledge the new idea.

24:30 Viruses play out as season changes. 

Increased melatonin during winter stimulates Th17, which creates flu/viral symptoms. After Winter Solstice, natural melatonin production decreases.

Coronavirus heat susceptible. 

Americans spend 98% of their time indoors. Can you say – Vitamin D deficiency?

27:39 family nursing homes

See 21:50

29:11 SARS / H1N1

Media designed around “If it bleeds, it leads”. Media protects their political darlings. 

“Never let a good crisis go to waste.” – Rahm Emanuel

Amygdala cannot tell virtual reality from reality. Whatever you perceive you will achieve.

Important not to continually stimulate the Amygdala with fearful, self-fulfilling prophecy. 

Everyone need to take a breath and relax in this weird time we live in. In the past few weeks, there has been a lot of information – most of it hype – about the Coronavirus. 

COVID 19 is a rather unique virus. 

Most usually concentrate on the Immune system AFTER the infection, after ACTIVATION has already occurred. Rather than preventing the infection by strengthening the membranes through which the virus enters the body. 

Most viral entry occurs via broken membrane walls.

COVID has a unique method (man made) to attach to 2 different cell proteins to gain entry.

  1. The first is through a Vit D sensitive receptor. 

Most Americans spend 98% of their time indoors leading to a Vitamin D deficiency.

This receptor site the virus tries to enter into is closed with High D3 levels.

  • Increase your Vitamin D intake. Get out side. 
Many people are asking me what they can use for prevention of Coronavirus. These can be ordered using the Doctor’s Supplement Store button.
I recommend the Liposomal Vitamin C by Designs For Health and Vitamin D for preventative measures. For Vitamin D and calming the immune system, I recommend the Ultra D 5000, Turmero Active, Resvero Active from Apex Energetics. Contact the office to order this product.
 1Designs for Health, Liposomal Vitamin C, 4 fl oz (120 ml)
 This is for prevention of the Coronavirus. 
Take 5 ml (approx. 1 teaspoon) and hold in mouth for 30 seconds before swallowing, or as directed by your health care practitioner. Refrigerate upon receipt. Use within 30 days of opening.
 
 1Wise Woman Herbals, Lomatium Dis., 2 fl oz (60 ml)
 This is not used as a preventative for the Coronavirus or other viral diseases. This is a take it – when you got it. 
Take 10-30 drops, 1-4 times a day.

2. The other is a Furin cleavage site which is commonly present on ALL cells. This furin-like cleavage site may provide a gain-of-function to the 2019-nCoV for efficient spreading in the human population.

This is an easy initial entry point.. aka “highly infectious”, but then met with an onslaught of an immune response, AKA “Cytokine Storm” stimulated by the TH17 immune system.

This is what is killing people..

Then, the body needs to RECOGNIZE the Pathogens and CONJUGATE them in order to PRESENT them to Macrophages.

  • This is where Vitamin C, Lomatium and again D3 play roles.

But again, COVID has a unique ability to gain entry. It IS highly infectious. But easily handled by a Healthy Immune system response..

Cases in the USA are matching those of Italy. A google search as of Mar. 15, 2020 shows only late February news. This indicates the number of cases are declining. Not good for the Fear Mongering News.

Because of this, the CASE numbers, ARE going to spike in the next 2 weeks. Especially with increased testing. But then the “Lethality” numbers will drop. However, more mild cases will be recognized.

Those with LOW D3 are most susceptible, 

Then those with poor Immune Responses, LOW antioxidant status will be most susceptible. 

Yes we can support OUR clients and patients and ourselves. By calming and quieting the immune response. (See 19:50 Increasing Immune Cells)

But most out there are clueless..

They continue to support a stimulation of the immune response. A person with an impaired immunoglobulin response will have an impaired stimulated immune response. It will be an inappropriate immune response. Yes, some will get lucky and it will do the job. For others it could make things worse as an over-fatigued immune system being stimulated can collapse and fail. Leaving the virus unchecked to enter the body. 

A calm, quiet and rested immune system responds appropriately. Vitamin C and Vitamin D will help with prevention by building walls to keep the virus out. 

Looking at Worldwide Trends, especially Europe, there WILL be a spike in the USA over the next 2 weeks (Mar. 14, 2020), and sadly, the News Media will exploit it and the USA will go crazy. (Watch what happens in Europe)

There is nothing WE can do about that.

Individual acts of defiance may make us feel better, but the world is gonna do what it’s gonna do. We can’t stop that. And we don’t want to put anyone in a situation that makes their lives more stressful than necessary. 

That is not helpful either.

This will be over in 90 days.

So just ride it out.

Lyme Disease: Real Disease / Fake Fad Diagnosis

Lyme disease, a tick-borne illness that has struck nearly 80,000 people since the CDC began keeping track in 1982 and now causes at least 8,500 new cases annually. Unfortunately, for most, it is a Fake Fad Diagnosis.

If the results of Antibody tests are tied only to symptoms, you are guaranteed to be diagnosed with whatever condition you are being tested for.

There’s no doubt that both acute and chronic forms of Lyme disease are real, that they’re caused by a spirochete passed by the bite of an infected tick and that they are treatable with antibiotics, says Dr. Allen Steere, director of the Lyme disease program at the New England Medical Center

“But along with that has come the ‘other’ Lyme disease,” he says, a syndrome of pain and fatigue of unknown cause.

It is of “unknown cause” because they are unable to get out of the Lyme Echo Chamber.

“Functional Medicine” preaches the “biochemical individuality” of each patient.

Lyme Disease Has Become a Profit-Centered Diagnosis du Jour.

How prevalent is Lyme becoming a Profit-Centered Diagnosis du Jour? Functional Medicine practitioners are now doing GROUP consultations. They are posting in the Social Media groups about how much it has increased their profits.

Both Doctors and Patients are seeking Social Proof unknowingly being controlled by Google and Social Media Algorithms.

Diagnosis is tricky because people had Lyme disease score positive on antibody tests long after the infection is over – even if their later problems have nothing to do with it. With the Lyme Illiteratii it will not matter if the lab results are negative. You will still have Lyme Disease. However, there is a problem with this. If you have ever had Measles, Mumps or Chicken Pox, you will have positive antibodies for Measles, Mumps and Chicken Pox. Does that mean you currently have Measles, Mumps and Chicken Pox? Think about how Lyme Disease has become a profit centered Diagnosis du jour.

Patient without any previous history of a tick bite with “Equivocal” results diagnosed with Lyme by Lyme iLiterati Doctor.

Of nearly 800 patients who visited Steere’s clinic during a five-year period, he says, 23 percent had chronic Lyme disease; another 20 percent had – had it and then developed something else, usually pain and fatigue that could be called Cytokine-Induced Sickness Behavior; and 57 percent had a pseudo-Lyme disease, usually a pain and fatigue syndrome caused by Cytokine-Induced Sickness and Multiple Organ Dysfunction Syndrome. Do the math. Seventy-seven percent (77%) do not have Lymes. Even with the 23% that previously “had” real-Lyme, it does not mean they will respond to an active-Lyme treatment. It occured in the past.

Doctor was strongly “recommending” MMR Booster for 26 year old Mother of child starting Kindergarten. Does She Need A Booster?

Now before you start quoting the Lyme Illiteratii, let me propose this scenario to you. You go to the Doctor for your fever and sore throat (Common Cold) symptoms. The Doctor is a Measles Mentor specialist. This Doctor runs a Measles antibody test to find you are positive for Measles “antibodies”.

Signs and symptoms of measles typically include:

  • Fever
  • Dry cough
  • Runny nose
  • Sore throat
  • Inflamed eyes (conjunctivitis)

You mention experiencing some abdominal pain, headaches and swelling of your legs during your period. The Measles Mentor instantly recognizes these are symptoms of Atypical Measles (AMS) – abdominal pain, abnormal liver function tests, edema (swelling) and headache. Your previous liver function tests are normal, but your MM Doctor doesn’t order any tests they would disprove their diagnosis du jour. They don’t like explaining lab results that would rule out their diagnosis du jour. They focus on antibody testing which is almost always positive and if it is not they will find a way to make it positive. It is guaranteed the Doctor will prescribe treatment for Atypical Measles (AMS).

The problem with this diagnosis and treatment is two-fold. You have a childhood history of Measles when you were nine years old, which gave you life-long antibody protection from measles. Years later your body’s immune system is producing antibodies to Measles. Thus the positive Measles antibody test results. The second is you are missing the rash. There is a stereotypical rash occurring with Measles. Where is it? Read More on the Lyme Rash.

36 year old woman told by MD, she needed MMR booster shot because her children are starting school.

The Measles Mentor Doctor explains very convincingly that you are having a “relapse”. Not everyone develops the Measles rash. That is why they call it “Atypical.” You are at a loss to question the diagnosis and treatment. So you start following the Measles Mentor Facebook group. Sure enough, you find everybody repeating what the Measles Mentor Doctor told you. You use Google to search for more information on Measles to find multiple Measles Mentor Doctors all publishing the same information. Not only that, they are having symposiums on Measles to educate people on the diagnosing measles, charging each person attending hundreds of dollars to attend.

Take notice here. They are publishing the same information because they are doing “copy and paste” from the founder of the Measles Mentor group. Some are adding the ubiquitous symptoms of brain fog, and fatigue to their description that are not specific to the disease. Other Measles Mentors have linked Measles to stubbing your toe in the middle of the night with the lights off. Remember the Inflamed Eyes being a symptoms of Measles. The Measles caused you to not be able to see the chair in the dark. Another example is this post regarding the thyroid in this screen shot from a social media influencer. You are guaranteed to have the symptoms of the diagnosis du jour.

Why Do the Antibody Rules Only Apply to Lyme?

None of the Lyme Illiteratti will discuss the following images. They start babbling and speaking in tongues. (Probably caused by Lyme) because it blows up their Lyme Antibody memes.

36 year old woman told by MD, she needed MMR booster shot because her children are starting school.
36 year old woman told by MD, she needed MMR booster shot because her children are starting school.
No matter the Medical specialty, they will be technically correct in their fields diagnosis.

If the 26 year old woman being coerced to get a MMR booster has positive Antibodies for MEASLES, MUMPS AND RUBELLA. She must have MEASLES, MUMPS AND RUBELLA according to the standards of diagnosis used by the Lyme Illiteratti. But wait, there is more.

Woman from Jordan has 57.9 Rubella IgG antibodies with no rash or symptoms. According to “Antibody” specialist she should have Rubella rash and symptoms.

A Woman from the country of Jordan (that’s in the Middle East) has Rubella Antibodies of 57.9. Wow!!! The 26 year old Rubella Antibodies were 3.17. Shouldn’t the woman from Jordan be covered in a red rash? The Lyme Illiteratti would be going bat crap crazy for a lab test with antibodies that high.

This brings into question the “Measles” epidemic in the United States. It may be a new strain of Measles that is being brought in by mass immigration.

Antibodies from Botox Injections

You can have a previous exposure to the bacterium Borrelia burgdorferi, which your immune system took care of. Eliminating it from you body but is now producing antibodies from that previous exposure. The same can occur with BOTOX injections. You can develop antibodies to Clostridium botulinum after receiving the BOTOX injections, but that does not mean you have Botulism.

Time to Get Serious

How many common symptoms are there between the popular diagnosed conditions? Too many conditions have the exact same overlapping symptoms. Professional and Social Media Influencers write books, post blog articles and host summits piling all of these symptoms onto their diagnosis du jour of choice. They present every symptom a person could possibly have all being caused by their diagnosis du jour of choice. When in fact in reality, you are allowed to have multiple organs dysfunctioning at the same time. Walking around the house in the dark is why your stubbed your toe, not the diagnosis du jour.

Is it “Hope for Lyme Disease” as in you hope for Lyme Disease. They teach you how to walk the walk to have Lyme Disease. They teach you how to talk the talk for Lyme Disease. You become a ATM machine for them.

Or is it “Hope for Lyme Disease” as in you feel bad. You have symptoms but it does not fit the criteria for Lyme Disease. Insurance companies, Professional and Social Media Influencers have trained us to to seek a diagnosis to better understand how you should be feeling.

Insurance Companies Complicate the Diagnosis Problem

Insurance companies dictate that you are only allowed one conditions at a time. Multiple conditions require exponential amounts of paperwork to document the multiple diagnoses. Which more that likely will cause payment for the treatment to be denied. Don’t assume just because the Doctor accepts your insurance co-payment they will inturn get paid by the insurance company. It is easier to play the game and give you the diagnosis du jour that pays the most.


One Condition = One Payment.
Multiple Conditions = No Payment.

This leads to the lumping of symptoms onto the actual symptoms of the diagnosis du jour. This leads to further confusion in the treatment. Professional and Social Media Influencers include the accumulated symptoms into the media they produce, which adds to their profit margin in added supplement sales.

Making a Diagnosis to fulfill the requirements for insurance payment is self-limiting. In that only one condition at a time will be paid for. This leads to a blurring of lines that define specific health conditions. Of these “diseases” – such as Lyme, chronic fatigue, fibromyalgia, myalgic encephalopathy, thyroid, Candida and depression, all have the same core symptoms.

Of these “Diagnosis du Jour” – such as chronic fatigue, fibromyalgia, myalgic encephalopathy (Which is now the replacement diagnosis for fibromyalgia.), thyroid, Candida and depression – which terms tells the Doctor and patient enough to search the internet about what is going on in their life or what to do based on the diagnosis du jour. This guarantees any symptom you have is going to be caused by the diagnosis du jour.

Are You Caught in the Diagnosis Trap?

The Internet makes it easy to fall into a trap. Professional and Social Media Influencers make their money by trapping you into a diagnosis du jour. Yes, those Social Media Influencers are monetizing (making money) by promoting a diagnosis. But they are so nice and caring. Yes, they are. All the way to the bank.

The trap that we fall into is called anchoring bias for a diagnosis du jour. The patient seeks the help of a Doctor with a set of complaints, usually self-diagnosed, that fit a broad range of conditions. Doctors, just as patients, follow the personality. Not the information. Once they get a label in their minds, they fit everything into that diagnostic box, anchoring all of the symptoms to that diagnosis, even ones that do not quite fit.

Anchoring or focalism is a cognitive bias that describes the common human tendency to rely too heavily on the first piece of information offered (the “anchor”) when making decisions.

For the doctors, this is a trap of a patient’s bias anchoring them to a diagnosis du jour. Patient with an anchoring bias seek help from Doctors with the same anchoring bias of the same diagnosis du jour. If the Doctor does not address the patient’s diagnosis du jour, they leave. Doctors are quickly trained by patients to give them what they want for business reasons.

If something doesn’t fit, don’t try to make it fit.

An example of this is a woman that sought help for her thyroid condition. Her thyroid labs were normal. She was unable to get out of bed. Her daily routine was bed to couch, then couch to bed. It took her several months to get labs done being unable to leave the house as she was. Her lab tests showed she was suffering from Hepatic Encephalopathy. Then it took her several months to take the supplement protocol. She was able to return to work and start exercising. After six months she called to ask when I was going to start treating her thyroid. I told her she didn’t have a thyroid problem. She got upset and left seeking the help of a “thyroid” specialist. This case reminded us to keep reciting the mantra: if something doesn’t fit, don’t try to make it fit. Ask what else might be going on. Don’t fall into the trap.

Let Me Be Clear!

At no time am I saying you are not feeling the way your are feeling. Doctors must be free of any preconceived notions on what is causing your symptoms. I understand you are feeling bad. Giving you a popular diagnosis du jour will make any treatment recommendations for it detrimental to your health. This further worsening of your health only serves to feed the bank account of the Professional and Social Media Influencers promoting the diagnosis du jour.

Are You Ready to Escape the Diagnosis du jour Echo Chamber?

Do you want a Doctor that looks at you without a diagnosis du jour agenda?  During the first contact with a patient I find out which echo chamber they are in. Then I determine if they are willing to step out of the echo chamber. It is up to the individual to stay out of the echo chamber.

The diagnosis du jour echo chambers are seductive. It may be easier to go through heroin withdrawal than to leave the diagnosis du jour echo chamber. Well, what if I do have it?

Whatever you perceive you will achieve.

How many Doctors have you been to? How much money have you spent on Doctors and treatments? The definition of insanity is doing the same thing over and over, expecting the results to change.

If you have read this far. Something must be resonating within you. You may be questioning your diagnosis du jour. You need to be independent of the opinions of those following the Professional and Social Media Influencers. Over and over, patients who’s health is returning, tell me their well-meaning friends are sending them links promoting their diagnosis du jour. This is an invitation back into the diagnosis du jour echo chambers. They don’t want you to leave. Be like them. Commiserate with them. Is that what you want? You could have a Jesus healing and they would still try to convince you that it didn’t occur.

Healing is not immediate. Especially, if you have a history of doing misguided treatments. It takes time. Six to eight weeks to heal a fractured bone. Three to seven days for a cut. Your body has the ability to heal. The immune system has a minimum of a two year memory. That does not mean you won’t feel better for two years. It means it is a slow gradual progression.

Call today if you want someone to look at you and unique circumstances causing the way you feel.

What is Th17?

The purpose of Th17 cells is to clear pathogens, which are not efficiently handled by TH1 and TH2 type of immunity. The induction of Th17 responses must go through three distinct steps: Induction, amplification and stabilization. The stability of Th17 population is only relevant if it is protective against a given pathogen-invader or other kind of insult. If Th17 cells loose their stability they become highly proinflammatory and promote the destruction of your body’s tissues as occurs in autoimmune conditions. In essence, your immune system chooses to sacrifice body tissues by destroying in order to preserve the rest of your body.

By promoting inflammation and attracting neutrophils, TH17-cells may help to remove microbes from the body. However, by triggering an excessive inflammatory response, TH17-cells can contribute to such inflammatory diseases as Hashimoto’s Thyroiditis, Crohn’s disease, Ulcerative Colitis, Psoriasis and many other Autoimmune conditions.

TH17 cells have recently emerged as a third independent type T cells which may play an essential role in protection against certain disease causing microbes.  IL-17 plays an important and unique role protection against specific pathogens. The production of IL-17 and the recruitment of neutrophils is important in protection against gram-negative bacteria and fungal infections. Th17 are highly pro-inflammatory and that Th17 cells with specificity for self-antigens lead to severe autoimmunity.

Game Changing Autoimmune Support to Calm and Quiet the TH17 response.

Forbidden Cytokines and Autoimmunity

T-cells secrete various cytokines through which they affect a broad spectrum of normal and pathological immune processes. Cytokine secretion by helper T cells is particularly important in autoimmunity[i] because chronic autoimmune diseases, such as Hashimoto’s Thyroiditis, Multiple Sclerosis, Type 1 Diabetes, and Rheumatoid Arthritis are predominantly caused by Th1 cells. Th2 cells can antagonize Th1 functions[ii] and in numerous autoimmune conditions prevent and/or cure autoimmune diseases.

However, recent studies found exceptions to this rule, suggesting that the behavior of a given T cell population may be unpredictable in its cytokine secretion profile. For example, (i) Th2-type T cells can be not only inefficient suppressors of autoimmune conditions induced by Th1 cells,[iii] but can cause Autoimmune conditions;[iv] thus Th1 and Th2 cells can both promote autoimmune conditions; (ii) Th0-type T cells (producing both Th1 and Th2 cytokines) can stimulate autoimmune conditions and are able to instigate Autoimmune conditions;[v] and (iii) Th2-type T cells can induce pancreatitis and diabetes in immune-compromised nonobese individuals with blood sugar problems.[vi]

The cytokine secretion of the same T cell population is different in the lymph nodes (producing both Th1 and Th2 cytokines) than in the central nervous system (CNS) environment (producing only Th1 cytokines). This observation suggests that within the CNS, specific factors (mainly IL-12 producing microglia acting as APCs, not neurons) can modulate the cytokine secretion of Tcells, can select Th1/Th2 pathway, and can control effector CD4+ T cell cytokine profile in Autoimmune conditions.[vii]

Four neuropeptides (NPs): somatostatin, calcitonin gene-related peptide, neuropeptide Y, and substance P, in the absence of any additional factors, directly induce a increased secretion of cytokines [interleukin 2 (IL-2), interferon-g, IL-4, and IL-10) from T cells. Furthermore, these NPs drive distinct Th1 and Th2 populations to a ‘‘FORBIDDEN’’ cytokine secretion[viii]: secretion of Th2 cytokines from a Th1 T cell line and vice versa. Such a phenomenon cannot be induced by classical antigenic stimulation.

The nervous system, through these NPs interacting with their specific T cell-expressed receptors, can lead to the secretion of both typical and atypical cytokines, leading to the breakdown of the commitment to a distinct Th phenotype, and a potentially altered function and destiny of T cells in vivo.

Nerve fibers that release NPs are widespread in the mammalian central and peripheral nervous systems, in certain endocrine tissues, and in all the primary and secondary lymphoid organs.[ix]

Somatostatin

Yeast/Fungi (ingested mold in this case) synthesize somatostatin using it as a defense mechanism to create their ideal environment. Normally, somatostatin is produce by the body in the gastrointestinal tract, pancreas and regions of the CNS. Classified as an inhibitory hormone, it has been shown to impede proinflammatory responses. Somatostatin secreted from non-neuronal cells along the digestive tract plays an important role as a mediator during mucosal inflammatory responses after physiological (induced by TNF-α) and pathophysiological (up-regulation of bacteria) stimulations. TH1, which predominates gastritis (gut inflammation), may be quelled through the increased levels of somatostatin. Through reduced inflammation, the yeast and other microbes are able to avoid attack by the TH1 immune system.

Yeast (Saccharomyces cerevisiae) used in probiotics, synthesizes an analogous peptide hormone precursor, pro a-factor, which is proteolytically processed by at least two separate proteases, the products of the KEXZ and STE13 genes, to generate the mature bioactive peptide somatostatin (SMS).[i],[ii],[iii],[iv],[v]

Expression in yeast of recombinant DNAs encoding hybrids between the proregion of a-factor and somatostatin results in proteolytic processing of the chimeric precursors and secretion of mature somatostatin.[vi]

Am I TH1 or TH2 or TH17?

In recent years, Doctors have become aware of a specific T-cell subset, termed TH17. TH17 creates Flu Symptoms, e.g. influenza, Morning Sickness, etc. TH17 contributes to the development of diseases such as multiple autoimmune diseases including allergic inflammation, rheumatoid arthritis, autoimmune gastritis, inflammatory bowel disease, Hashimoto’s, psoriasis, and multiple sclerosis.

Some practitioners recommend the Th1/Th2 Challenge to determine if symptoms are immune related. Doing the Th1/Th2 Challenge is like checking for a gas leak with a burning match. It doesn’t account for Th17. Are you suffering from inflammatory fire searching the internet for answers? I often hear from women that they have to be their own advocates for their health. I agree you must be your own advocate.


Inflammation is a general term describing the effects of too many inflammatory cytokines and stimulating neurotransmitters unopposed by too few anti-inflammatory cytokines and inhibitory neurotransmitters.

Finding Your Immune Status

For more than thirty years, T-Helper (TH) cells have been divided by immunologists into two functional subsets: T-helper-1 (TH1) and T-helper-2 (TH2). Immunologists have also identified specific groups of chemical messenger molecules called “cytokines and chemokines” that are used to communicate between the cells of the immune system and stimulate either the TH1 or TH2 system.

How much do you know about the immune system?

TH1/TH2 Challenge

When the activity of one subset goes up, it represses the activity of the other similar to a seesaw or teeter-totter. Some practitioners recommend the TH1/TH2 Challenge to determine if symptoms are immune related. In this test, one immune stimulating supplement is taken at a time and a journal is kept of the symptoms experienced. One supplement stimulates the TH1 side of the immune system, and the other supplement stimulates the TH2. The reactions to these supplements are used to determine which side of your immune system is out of balance. However, very few people are strictly TH1 or TH2.

Fig. 1: Provocation of Unregulated Immune Response

Very Few People Are Strictly TH1 or TH2.

People with similar symptoms can have remarkably different laboratory results, while people with comparable laboratory results often exhibit widely different symptoms. This leads to confusion and frustration when doing immune challenges. Results from the Neuroscience NEI Gold 5516 for women suffering from Hashimoto’s show how confusing and unpredictable it can be.

Immune Status Scale

Many consider the immune system to be always working properly, even with autoimmune conditions. When it is actually compromised and experiencing the effects of too many inflammatory cytokines and stimulating neurotransmitters unopposed by too few anti-inflammatory cytokines and inhibitory neurotransmitters, while being hacking into and disrupted by microbes, bacteria and parasites.

Another favorite is to blame food or something from the environment. While they can and do serve as provocateurs in an Immune compromised individual. Microbes, bacteria and parasites hack into the NEI Supersystem damaging or altering the immune response for their survival resulting in false positive and false negative food antibody test results.

Antibody Testing

The current dogma is that Immune cells are stimulated by Antibodies. They believe as long as antibodies are present, the antibodies are constantly stimulating an immune response. They also are lead to believe the presence of antibodies are from an ongoing infection. Typically, IgG antibodies are produced in the first phase of immune responses. However, the immune response to IgA, IgG, and IgM declines or is terminated along the course of the disease in most patients. IgM antibodies are indicative of an ongoing immune response., Studies have shown the detection of IgA and IgM antibodies in 62% and 61% of IgG antibodies in autoimmune patients, and after 7 years.,

A resolution of the disease is not associated with a decrease in antibodies. Only those with a short disease duration are likely to experience a decrease in antibodies levels. For most autoimmune patients there is no significant change in antibody levels, However, patients with immune calming/quieting treatment, experienced a 20% decline in their antibody levels. Normalization in the levels of antibodies with treatment intervention occurs in less that 7% of patients. The success of clinical interventions in lowering antibody levels (and thus likely minimizing the pathogenic effects of autoantibody binding) appears to be dependent on disease duration. The association of shorter disease duration with greater declines in antibody levels is highly consistent with the growing body of evidence that shows improved clinical outcomes with earlier disease intervention in autoimmunity.,,

Approximately one-half of patients with Rheumatoid Arthritis had positive IgM-RF and/or antibodies on at least 1 occasion, almost 5 years prior to disease onset. More than 50% of autoimmune patients may have positive antibodies upwards of 13 years after disease resolution, regardless of treatment.

Immune Compromised Individuals

In the Immune Compromised individual, the immune response the response will depend on their immune system status. This can be best measured by the Neuroscience Stimulated Cytokine panel. The Immune Status Scale (Fig. 2) is not measurable but represents a means to demonstrate the compromised immune system.

  • Zero is DEATH through an acquired immune deficiency and an incompetent immune system.
  • From zero to 30 denotes an ineffectual immune system activity characterized by extreme weakness with tremendous loss of any immune response in the body.
  • The point 30 denotes approaching death unless an immune response can be stimulated which will give it a higher potential ability to protect oneself.
  • From point 30 to 60, there is immune suppression with a decreasing ability to respond to immune challenges with symptoms of cytokine-induced sickness behavior.
  • Symptoms of cytokine-induced sickness behavior begin appear as the body nears 60. A competent immune system will be able to return the body to above 60.
  • From 60 to 100, we note complete health, with 100being the maximum quality of perfect being.
  • From 100 to 150, we note immune stimulation with symptoms of cytokine-induced sickness.
  • From 100 to 130, there is immune stimulation in response to immune challenges. A competent immune system will be able to return the body to below 100.
  • At 130, we will note symptoms of complete cytokine-induce sickness.
  • At rate 150– death takes place through Septic shock, Anaphylaxis, or Toxic Shock

The immune system can jump from the immune suppressed range to the immune stimulated range during a cytokine storm or when provoked and back again. The tissue producing the immune cells may fatigue contributing to a yo-yo effect of cytokine storms followed by a collapse of the immune response as the tissue recovers.

Cytokines that enhance cellular immune responses, Th1 (INf-?, TNF?, etc.), Th2 (TGF-?, IL-4, IL-10, IL-13, etc.), Th17 (IL-17, Il-21, Il-22, IL-26, G-CSF, TNF?), and Th9 (Il-9) favor antibody responses. Cytokines binding to antibodies create a stronger immune effect.

Cytokine Storms

Cytokine storms may occur in both Immune Suppressed and Immune Stimulated. Chances are you have if you are suffering from Hashimoto’s, autoimmune conditions or a confusing mess of symptoms, you may be experiencing your very own Cytokine Storm season where you will have bad days followed by calm days after the storm and again by bad days. You may have found yourself in the proverbial “up a creek without a paddle” in your autoimmune world.

Cytokine Storms occur when the immune system becomes and remains activated against the immune stimulants beyond the point of being helpful.

Lectin Toxicity Evades Antibody-Based Blood Tests

While it is clear that lectins have the potential to do harm, it must be emphasized that the type of harm they do is harder to diagnose than in classically defined food allergies or sensitivites. In other words, confirmation of intolerance will not be found in antibody, allergy or intestinal biopsy testing because the damage done is a direct cytokine driven response, and not necessarily immune-medicated or only secondarily so.

The diagnostic “invisibility” is why lectin consumption is rarely linked to the ailments that afflict those who consume them. While lectins are not the sole or primary cause of a wide range of disorders, them are a major factor in sustaining or reinforcing injuries or diseases once they are initiated and/or established in the body.

Fig. 3: Four Stimulated Cytokine Test Results
Base: General Overall Immune Response

Blue: Zero to 60– Immune Suppressed or Immunocompromised (Fig. 2)
Red: 100 to 150– Immune Activated or Stimulation (Fig. 2)

As you can see from the Stimulated Cytokine Test results that you can be Immune-Stimulated and Immune Suppressed simultaneously. You may experience symptoms of both a suppressed and stimulated immune system (see Fig. 2).

All had bad reactions with the Th1/TH2 challenge. Why? All have an overactive Th17 immune response. Three have a suppressed TH1 response. One has a suppressed TH2 response. The upper right is immunocompromised. The lower right is immune stimulated to everything. The lower left is a raw vegan over-consuming Soft and Hard Lectins. The upper left TH1 immune system collapses when exposed to bacteria driving straight into TH17.

You also have to apply some common sense. Common sense would tell you with autoimmune conditions your immune system isn’t working properly. Are you going to trust it to be accurate during a TH1/TH2 challenge? Lab testing is the best way to determine your immune status.


The TH1/TH2 Challenge does not recognize the TH17 response, immune suppression or stimulation.

In recent years, Doctors have become aware of a specific T-cell subset, termed TH17. TH17 creates Flu Symptoms, e.g. influenza, Morning Sickness, etc. TH17 contributes to the development of diseases such as multiple autoimmune diseases including allergic inflammation, rheumatoid arthritis, autoimmune gastritis, inflammatory bowel disease, Hashimoto’s, psoriasis, and multiple sclerosis.

The TH1/TH2 Challenge does not recognize the TH17 response, immune suppression or stimulation. Confusing results occur when different immune status responses are not accounted for as seen in Fig. 1.

Figure 1: Rheumatoid Arthritis

It is much better to provoke an immune response in a laboratory setting than suffer the consequences of a failed TH1/TH2 challenge. Formerly, the Neuroscience NEI Gold (5516) determines the baseline immune status and whether lectins (PHA) or bacteria (LPS) provoke a TH1, TH2 or TH17 response. Unfortunately, it is no longer available. As seen in Fig. 1 the immune system can fail when provoked (blue color) resulting in a suppressed immune system. Measurement of stimulated cytokines can identify the presence of an excited or suppressed immune status.

Are Edible Enemies contributing to poor health and inflammation? Lectins cause a plethora of damage to the body, promoting chronic inflammation and sensitivity. Take the Edible Enemy Quiz to test your knowledge on lectins.

Use the Lectin Control Formula to reduce the inflammatory response that occurs due to lectin consumption. Take two capsules with each meal.

TH1

Th1-lymphocytes are primarily made in response to microbes that infect or activate macrophages and Natural Killer cells, and in response to viruses.

Th1-type cytokines tend to produce the proinflammatory responses responsible for killing intracellular parasites and for perpetuating autoimmune responses. Interferon gamma is the main Th1 cytokine. Excessive proinflammatory responses can lead to uncontrolled tissue damage, so there needs to be a mechanism to counteract this.

TH2

TH2-lymphocytes are primarily made in response to helminths (worms), allergens, and extracellular microbes and toxins. The TH2-type cytokines include interleukins 4, 5, and 13, which are associated with the promotion of IgE (severe allergies) and eosinophils response, and also interleukin-10, which has more of an anti-inflammatory response. In excess, TH2 responses will counteract the TH1 mediated microbial killing action. The optimal scenario would therefore seem to be that we should produce a well-balanced Th1 and Th2 response, suited to the immune challenge.

TH17

The purpose of Th17 cells is to clear pathogens, which are not efficiently handled by TH1 and TH2 type of immunity. The induction of Th17 responses must go through three distinct steps: Induction, amplification and stabilization. The stability of Th17 population is only relevant if it is protective against a given pathogen-invader or other kind of insult. If Th17 cells lose their stability they become highly proinflammatory and promote the destruction of your body’s tissues as occurs in autoimmune conditions. In essence, your immune system chooses to sacrifice body tissues by destroying in order to preserve the rest of your body.

TH17 and Vaccine-Related Injuries

Mercury or aluminum is put into vaccines to stimulate an immune response the contagious bacteria with the intention of developing immunity to the disease causing microbe. However, if a child is born with an over active TH17 response from the mother during pregnancy. A reaction, small or catastrophic may occur leaving the child impaired or worse. It is important to determine the immune status of the woman prior to or during pregnancy. Dr. Peterson can provide the answers to this.

TH17 is not included in the TH1/TH2 Challenge

The TH-1/TH-2 Challenge as noted in the book “Why Do I Still Have Thyroid Symptoms?” was printed prior to understanding of TH-17. The TH-1/TH-2 Challenge may provoke a TH-17 response. The TH-17 destroys tissue rather than allowing it to be inflamed; analogous to a suicide bomber attack that you can not defend against.

We can and do use laboratory testing, with equipment from companies like SciQuip, to determine your autoimmune response. We recognize the impact of autoimmune conditions and the possibility of false positives and false negatives when using such labs. We start by using H.I.S.S.

  • History
  • Information
  • Signs
  • Symptoms

By utilizing a step-wise approach: Ask questions first. Lab test second. Immune challenges should be done in a laboratory – not your body. The physicians at Wellness Alternatives can determine the most likely scenario involving your immune system without provoking an uncontrolled immune response.

Very few are strictly TH-1 or TH-2.

Those with TH-1 dominance creating symptomatology usually feel better with coffee or caffeine. But feel worse with immune stimulators – Echinacea, goldenseal, immune-boosting mushrooms or probiotics. A person with TH-2 dominance creating symptomatology are the opposite. They will feel better with immune stimulators – Echinacea, goldenseal, immune-boosting mushrooms or probiotics and feel worse with coffee or caffeine.

Concerned about your Health?

Call today! 530-615-4083

Very few are strictly TH-1 or TH-2. This leads to confusion and frustration when doing immune system challenges. More often than not a person will be both TH-1 and TH-2 with multiple autoimmune conditions, i.e. >80% with Hashimoto’s also have Autoimmune Gastrointestinal Disease. This happens when different autoimmune diseases are actively provoking both sides of the immune system to be overactive and the regulatory part of the immune system can’t regulate either side. When a person has both TH-1 and TH-2 creating symptomatology, they often come into the office saying: “I’m always sick” or “I’m allergic to everything.” When TH-1, they will feel worse with immune stimulators – Echinacea, goldenseal, immune boosting mushrooms or probiotics and feel better with little amounts of coffee or caffeine. Which causes a shift pushing them into an overactive TH-2 response were they will feel worse with coffee or caffeine but feels better with little amounts of immune stimulators – Echinacea, goldenseal, immune boosting mushrooms or probiotics.

This eventually drives them into a place where neither TH-1 nor TH-2 creates symptomatology but both are over reactive and under reactive at the same time. They will happily report, “I never get sick” in addition to “But I know I’m not well.” This is scary because their immune system is no longer able to protect them. They are slip sliding away down the slippery slope of autoimmune diseases because their immune system is too fatigued for any appropriate response. Those that add, “I feel good” are doing Green Allopathy often fall into this category. When we look at their labs they will have low absolute neutrophils (<1800) and lymphocytes (<1500). Some will have only one low – others both. Those with an underactive TH-2 will tell us they feel better with a little coffee, or caffeine but feel worse with moderate amounts of coffee, caffeine – as they are driven into TH-2 dominance. At the same time they also have an underactive TH-1 where they feel better with a little immune stimulators – Echinacea, goldenseal, immune boosting mushrooms or probiotics but feel worse after a time with moderate amounts of immune stimulators – being driven into TH-1 dominance.

Reregulating the immune system

Rather than supporting either the TH1 or TH2 while ignoring the TH17 dominance. Wellness Alternatives recommends Quieting the Immune system and doing everything we can to not provoke any immune response. Think of it as if you are being quiet after finally getting a cranky baby asleep. You don’t want to do anything to wake it up. In addition to this we support the T-Helper, T-regulatory cells and inhibitory neurotransmitters and cytokines to re-regulate the TH1, TH2 and TH17 immune response.

Now a quick jump back to the antibody story. It has been proposed that antibodies are normally inactive in a healthy individual. It has been said that 60% or more of the action of a healthy immune system is to deal with the leakage of larger food molecules from the gut. There is, after all, a high degree of similarity between various mammalian animal proteins in our diet and those found in our bodies. If our immune system were to attack all instances of these proteins, we would all have arthritis, lupus, and many other autoimmune diseases. Yet, in some people this type of antibody based damage does occur.

Calm & Quiet, Don’t Suppress or Stimulate Your Immune System

Taking supplements to stimulate one side because you did a TH-1/TH-2 challenge will only make both sides overactive. Yes, in theory taking supplements stimulating the TH-2 is supposed to control the TH-1 after immune regulation has been achieved. The reason you have an autoimmune disease is largely due to an inability to control your immune response. If the immune regulation was not working before the challenge, chances are very high, it will not work by provoking the other side.

It is ill-advised to provoke an immune system that cannot regulate itself.

Do not write checks your body cannot cash.

The physician at Wellness Alternatives utilize supplement protocols to quiet and re-regulate your immune system. This may involve supporting the regulatory or helper T Cells or the inhibitory cytokines and neurotransmitters. Care must be taken as noted previously as sometimes supporting the regulatory/helper T cells can provoke the inhibitory cytokines and neurotransmitters or vice versa into having an adverse response.

Find out WHAT is the root cause; what initial incident, infection, chronic or otherwise, is provoking and perpetuating this immunological alert status. Then deal with it!

  • DO whatever is necessary to QUIET, not suppress or stimulate, your immune system.
  • DO rotate your diet.
  • DO try to avoid many of the immune stressors in your environment.
  • KEEP a diary so you can LEARN what those stressor are! Start comparing them, you may find common ingredients, which are the provoking your immune system. This too, gives you more slack, as you can then use things without those ingredients.

For effective strategies to prevent immune-mediated disorders, including food allergy, it is essential to understand the external variables that influence immunological programming and how they interact with genetic predisposition to disease. Knowing that Autoimmune processes can be arrested if the interplay between genes and environmental triggers is prevented by re-establishing intestinal barrier function. The physicians at WA use the following 4 principles to re-establish the intestinal barrier function.

  • Restore the Gastrointestinal Barrier Variables
  • Restore the Gastrointestinal Digestive Sequencing
  • Restore the Gastrointestinal Terrain
  • Calm and Quiet the Immune system
  • Restore the Neurotransmitter imbalance

Concerned about your Health? Call today! 530-615-4083

Is Low Dose Naltrexone (#ldn) Stimulating Autoimmunity?

Naltrexone (#ldn) is usually used in 50mg doses as a drug to help heroin or opium addicts, by blocking the effect of such drugs.  By blocking opioid receptors, naltrexone also blocks the reception of the opioid hormones (endorphins) that the brain and adrenal glands produce.   Many body tissues have receptors for the endorphins, including virtually every cell of the body’s immune system.

FDA-approved naltrexone, in a low dose (only 3mg), can boost the immune system, helping those with HIV/AIDS, cancer, and Autoimmune Diseases. The Immune System is “uncontrolled”in Autoimmune conditions. Boosting an uncontrolled Autoimmune response is a bad thing.

Too many people think symptom suppression using Green Allopathy (Supplements) and Allopathy (Drugs) is healthy.

LDN is currently under experimental use for many conditions.  Preliminary results in theory are very encouraging: Naltrexone increases the body’s production of the beta and metenkephalin endorphins and blood tests have indicated that it can double or even triple the activity of natural killer cellsNaturalkillercells(also known as NK cells, K cells, and killercells) are a type of lymphocyte (a white blood cell) and a component of innate immune system. NK cellsplay a major role in the host-tissue rejection of both tumours and damaged cells.

Oh, but Doc, this is Low-Dose Naltrexone. My response: A single spark can ignite a forest fire.

A wealth of experimental data suggest that T cells are self-restricted or self-regulated. Immune regulators of the NEI Supersystem cannot be too high or too low as the self-regulation is dose-dependent. Artificially suppressing or stimulating the levels has detrimental effects on the immune response.

LDN works by suppressing the immune system. Eventually, to quote, Dr. Ian Malcolm of Jurassic Park:

… the kind of control you’re attempting simply is… it’s not possible. If there is one thing the history of evolution has taught us it’s that life (the immune system) will not be contained. Life (the immune system) breaks free, it expands to new territories and crashes through barriers, painfully, maybe even dangerously, but, uh… well, there it is.

There are three different methods by which the body fights infections.  While cellular immunity (Th1) directs Natural Killer T-cells and macrophages to attack abnormal cells and microorganisms at sites of infection inside the cells, humoral immunity (Th2) results in the production of antibodies used to neutralize foreign invaders and substances outside of the cells. T helper 17 cells (Th17) are a subset of T helper cells producing interleukin 17 (IL-17). They are developmentally distinct from Th1 and Th2 cells. Th17 cells are associated with autoimmune disease. The Th17 effector cells are triggered by IL-6 and TGF beta or IL-23 and IL-1β.

Anti-Inflammatory Drugs work by “Suppressing” the immune response. Natural anti-inflammatories work by calming the immune response.

In many cases, all three arms of the immune system fight an infection.  At other times, only one is predominantly needed to control an infection.  A healthy immune system is both balanced and dynamic: it should be balanced between Th1 and Th2 and Th17 activity, switching back and forth between the three as needed.  This allows for a quick eradication of a threat and then a return to balance before responding to the next threat.  The inability to respond adequately with a Th1 response can result in chronic infection and cancer; an overactive Th2 response can contribute to allergies, various degenerative syndromes and autoimmune disease is a consequence of a Th17 response.  In autoimmune illnesses, all of the arms of the immune system are active, creating the inflammation and tissue injury in autoimmune disease.

All Components of the NEI Supersystem – including Cytokines and Chemokines are Dose-Dependent

A failure of the Th1 arm of the immune system and an overactive Th2 arm is implicated in a wide variety of chronic illnesses.  These include autoimmunity, CFS, candidiasis, multiple allergies, multiple chemical sensitivities (MCS), viral hepatitis, Hashimoto’s thyroiditis, cancer and other illnesses.  If these three arms of the immune system could be balanced by stimulating Th1 and decreasing Th2, then many of the symptoms associated with these chronic illnesses would diminish or disappear and we would have found the answer to immune restoration and balance or the equivalent of a cure. Unfortunately, where Th1 and Th2 leaves off, Th17 takes over and most treatments don’t take account of Th17. This is definitely the case for Low Dose Naltrexone (LDN).

While correct in theory, it is incorrect in terms of how the immune system functions. Most view the immune system only in terms of Th1, Th2 and rarely if ever include Th17. Cytokines, chemokines, neurotransmitters and hormones that control the Th1, Th2 and Th17 responses direct the immune response. Hormones are always thought of as only involved in sex and reproduction. However, progesterone, estriol and testosterone are immune suppressive. While two of the estrogens – estrone, and estradiol are immune stimulating. Not to mention the inflammatory hormone Etiocholanolone, which is rarely tested for and drives the Th17 response. Yes, Etiocholanolone is a hormone made from DHEA that drives Th17. All too often low DHEA is thought to be an adrenal problem, when it is actually being converted into etiocholanolone. Neurotransmitters work both to alert the immune system to an area of the body in distress and signal the immune system that the work is over. Again, rarely tested for. Collectively, this is known as the NEI Supersystem.

Th1 cells secrete INF-gamma and IL-2, which activate macrophages and cytotoxic T-cells to kill intracellular organisms; Type Th2 cells secrete IL-4, IL-5, and IL-10, which help B cells to secrete protective antibodies. Th17 cells are triggered by IL-6, IL-17, IL-1β, and IL-23 to clear out damaged tissue damaged by autoimmunity or the uterine lining during menstrual cycles or miscarriages.

Interferon gamma (IFNγ) is secreted by T helper cells (specifically, Th1 cells), cytotoxic T cells (TC cells), macrophages, mucosal epithelial cells and NK cells. Among the effects of increased IFNγ are:

  • Promotes NK cell activity
  • Increases antigen presentation and lysosome activity of macrophages.
  • Activates inducible nitric oxide synthase (iNOS)
  • Induces the production of IgG2a and IgG3 antibodies from activated plasma B cells
  • Causes normal cells to increase expression of class I MHC molecules as well as class II MHC on antigen-presenting cells.
  • Promotes adhesion and binding required for leukocyte migration
  • Induces the expression of intrinsic defense factors.
  • IFNγ is the primary cytokine that defines Th1 cells: Th1 cells secrete IFNγ, which in turn causes more undifferentiated CD4+ cells (Th0 cells) to differentiate into Th1 cells.

I recommend calming and quieting the immune system so it can respond appropriately when needed.

Low Dose Naltrexone works by stimulating suppression of the immune response. When immune suppression occurs, those using LDN don’t feel the pain and discomfort with their immune system being suppressed. It’s a win/winsituation. The patient isn’t feeling any pain and the Doctor isn’t getting asked by the patient isn’t feeling any better.

Low Dose Naltrexone works by Stimulating Suppression of the Immune system.

Parsing the Benefits of LDN

It’s worth mentioning LDN “stimulates” suppression. Proponents will parse it to “LDN works by stimulating an immune response.” Conveniently leaving off the end of the statement. “LDN works by stimulating an immune response to calm down or stop inflammatory immune responses (AKA – suppression).” Technically they are correct. By convention today, there is an agreement to only look at one aspect when publishing medical studies. They publish a study showing LDN works by stimulating a immune response. End of story. They assume those in the know reading this study would understand the consequences of this “stimulation.” However, the average person or Doctor(s)  (Don’t assume Doctors know much about the immune system) doesn’t know or care how it works. They only want to know will it give relief. Consequences be damned.

Fact: Inflammation is an immune response.

In answer to “a common anecdotal report is that people don’t get the common cold as much. Technically, they are correct. But??? They are equating not getting sick to a normal healthy immune system. After seeing the results from the Stimulated Cytokine lab test. I realized the reason they not getting sick is because their immune system is so fatigued or suppressed that no symptoms are generated. They come to my office reporting they feel like crap but they “never get sick”. “How can I be so healthy but feel so bad?”

Those using LDN usually report a blissful period where their inflammation (see fact above) subsides. Usually for a four to six month period; then other components of the immune system become overstimulated without the feedback control from the components that LDN suppressed. They have had half a year for smoldering inflammation doing further damage to their body. The good news is they will not feel it. The bad news is they will now seek help from a Doctor that will recommend immune stimulating supplements. Exacerbating the condition and the damage being done.

Alternative / Functional treatments focus on Stimulating the Immune Response.

Naltrexone Treatment by Immune Stimulation

A possible line of therapy being investigated by the medical community is to reintroduce some of these cytokines to people who have severe immune deficiencies.  This approach can be tricky because large amounts of any particular cytokine can have serious side-effects. This approach fails to recognize fatigued cells that are too exhausted to produce immune cells cause the deficiencies. How is stimulating the immune system beneficial?

The immune system by design provides your body with numerous layers of protection with a multiple backups. The system is set up so that if the responsible system is unable to handle the job and bigger, stronger system is recruited. Thus, if the basic Th1 or Th2 systems are fatigued to respond, the Th17 system is alerted to come in and take care of business.

Naltrexone Stimulation of the Immune System

Naltrexone treatment increases NK cell cytolytic activity and cytokine production in the spleen. Chronic naltrexone administration enhanced both basal and the cytokine-modulated NK cell cytolytic activity and IFN-γ production.

Naltrexone treatment increased the production of IL-2, IL-4, IL-6, and IL-18 and the basal and cytokine-activated NK cell cytolytic activity and IFN-γ production in the splenocytes. Chronic administration of naltrexone stimulates the production of cytokines and NK cell cytolytic activity in splenocytes. Naltrexone does not block IL-1β.,

Naltrexone Stimulation of NK cells

Natural killer cells are a T cells that share properties of both T cells and natural killer cells. NK cells can also produce many different cytokines as well as chemokines.  T cells are inherently cross-reactive, and this versatility and specificity is a hallmarks of adaptive immunity. T cells are prone to be autoreactive and thus able to induce autoimmunity.  Increasing the NK cell avtivity results in enhanced alloreactivity  and autoimmunity.

IL-2 promotes the differentiation of T cells into effector T cells and into memory T cells when the initial T cell is also stimulated by an antigen.

IL-2 does not specify the type of Th differentiation that occurs; instead, IL-2 modulates expression of receptors for other cytokines and transcription factors, thereby either promoting or inhibiting cytokine cascades that correlate with each Th differentiation state. In this fashion, IL-2 can prime and potentially maintain Th1 and Th2 differentiation as well as expand such populations of cells, whereas it inhibits Th17 differentiation but also can expand Th17 cells.

IL-2 has a narrow therapeutic window, and the level of dosing usually determines the severity of the side effects. Some common side effects:

  • Flu-like symptoms (fever, headache, muscle and joint pain, fatigue)
  • Nausea/vomiting
  • Dry, itchy skin or rash
  • Weakness or shortness of breath
  • Diarrhea
  • Low blood pressure
  • Drowsiness or confusion
  • Loss of appetite

More serious and dangerous side effects sometimes are seen with increased IL-2, such as capillary leak syndrome, breathing problems, serious infections, seizures, allergic reactions, heart problems or a variety of other possible complications.

T-cell recognition is essential for protection against microbial pathogens, recognition of self-peptides by T cells that have escaped negative selection in the thymus can lead to autoimmune disease. A disregulated T cell interaction can initiate autoimmunity. Thus, antigen recognition by T cells must be tightly regulated in order to ensure protection against pathogens and tumors, avoiding activation of self-reactive T cells.

NK cell cytolytic activity has been shown to be activated by interferon-γ (IFN-γ), which has a number of opioid-like effects. Various other cytokines are also known to increase NK cell cytolytic activity and lymphocyte proliferation. Of these cytokines, interleukin (IL)-2, IL-12, and IL-18 stimulate NK cell cytolytic activity. Other cytokines like IL-4 and IL-6 are known to regulate NK cell proliferation and differentiation. Cytokines IFN-γ, IL-2, IL-4, IL-6, IL-12, and IL-18 have been shown to also affect the function of other immune cell populations in splenocytes.

Alcohol consumption is also known to suppress Lectin-induced production of various cytokines, including IL-2, IL-6, and IL-4 from splenocytes. Initially, Naltrexone therapy counteracts the suppressive effects of alcohol on NK cell cytolytic activity for the first couple of weeks allowing increase production of IL-2, IL-6, and IL-4 from splenocytes.

Naltrexone Stimulation of Chemokines

Naltrexone is an opioid antagonist when administered the first couple of weeks, but shows δ-opioid-like activity following chronic long-term administration. With constant use naltrexone selectively promotes the δ-opioid receptor activity and enhances NK cell cytolytic activity response to β-endorphin. Naltrexone disrupts the feedback control that results in enhanced NK cell cytolytic response.

The chemokines, macrophage inflammatory protein-1 (MIP-1) and its subunit MIP-1 beta, induce an intense fever. The central action on body temperature (Tb) of MIP-1 beta with that of interleukin-6 (IL-6), has been implicated in the mechanism underlying the pathogenesis of fever along with etiocholanolone. This is potentiated by the presence of lipopolysaccharide.

Naltrexone increases in neutrophil-associated myeloperoxidase activity and chemokine mRNA expression, including macrophage inflammatory protein-1 alpha (MIP-1α) and -2 (MIP-2).

LDN could enhance both morphological and functional maturation of bone marrow dendritic cells (BMDCs). Their main function is to process antigen material and present it to the cell surface to the T cells of the immune system. They act as messengers between the innate and the adaptive immune systems. LDN markedly up-regulates expression of key surface molecules, which will trigger a chain of cell mediated responses. In addition to this, LDN also markedly upregulate production of cytokines IL-12 and TNF-α, which will trigger Th1 cell response.

Dendritic cells are present in those tissues that are in contact with the external environment, such as the skin (where there is a specialized dendritic cell type called the Langerhans cell) and the inner lining of the nose, lungs, stomach and intestines. They can also be found in an immature state in the blood. Once activated, they migrate to the lymph nodes where they interact with T cells and B cells to initiate and shape the adaptive immune response.

Interleukin (IL-1), tumor necrosis factor α (TNFα), IL-3, and IL-6 collaborate with GM-CSF. β-endorphin increased the number of macrophage colonies when bone marrow cells were cultured in the presence of GM-CSF plus lipopolysaccharide (LPS). Naloxone and Naltrexone, an antagonist of endorphins for opioid-receptors, completely abolishes the effect of β-endorphin. Both Naloxone and Naltrexone stimulates suppression of the production of GM-CSF.

Naltrexone Stimulates Suppression of Cytokines

Naltrexone and naloxone stimulates suppression of microglia activation, reduces the production of re- active oxygen species and other potentially neuroexcitatory and neurotoxic chemicals.

Naltrexone causes a significant decrease of IL-12 and IL-10 production by macrophages. With chronic dosages, IL-12 remaines significantly suppressed. As for IL-10, naltrexone seems to partially prevent the IL-10 reduction. Naltrexone significantly inhibited the production of TNF-alpha induced by LPS.

Naltrexone Stimulates Suppression of Chemokines

The anti-inflammatory effect of opioid antagonists naltrexone and naloxone also extend to the periphery, as evidenced by stimulates suppression of TNF-alpha, MCP-1, and other inflammatory agents in peripheral macrophages.

Stimulated Cytokine Testing on LDN Patient

The lab results shown below are from a woman using Naltrexone therapy. Despite feeling better on the Autoimmune protocol recommended to her, she stopped doing the Autoimmune protocol after deciding to start Naltrexone.

After starting the Naltrexone, things changed drastically. A lot of the old symptoms reappeared and some got worse. She was experiencing severe pain on right side of body from neck and shoulder down to her hip and ankle. Her low back was really bad, and she could hardly walk being constantly achy and sore. She could not get out of bed, and had diarrhea a couple of times a week. When she gets a flair up – it can occur for no reason and they are lasting longer. Unfortunately, she failed to mention the LDN therapy.

Naltrexone Induced Ischemia

Ischemia is a restriction in blood supply to tissues causing a shortage of oxygen and glucose needed for cellular metabolism (to keep tissue alive). Ischemia is generally caused by problems with blood vessels, with resultant damage to or dysfunction of tissue.

Neurons that demonstrate particular vulnerability to ischemic challenges have been termed “selectively vulnerable neurons”.  Of the entire brain, the neurons of the hippocampus are the most vulnerable.

This would result in problems with endocrine system, (thyroid, hormone, adrenal) as the blood-brain-barrier would be further compromised as a results of compromised (ischemic) blood flow to the pituitary, hypothalamus and hippocampus.

Exogenous ligands, i.e. naltrexone, that activate the δ receptors mimic the phenomenon known as ischemic preconditioning. Ischemia preconditioning/hypoxia preconditioning (IPC/HPC) is a phenomenon whereby brief ischemia/hypoxia “preconditions” cells and increases cellular resistance against subsequent lethal ischemia/hypoxia injury. Short periods of transient ischemia are induced the downstream tissues are robustly protected. This serves as a protective mechanism to restrict blood flow around an inflamed area of the body to prevent inflammation or microbes from spreading throughout the body. It is intended for short periods until the immune system is able to control the situation. If longer-duration interruption of the blood supply is then effected, ischemic damage from the lack of oxygen, glucose and elimination of cellular waste products occurs. Naltrexone and naloxone with δ activity mimic this effect.

Naltrexone Reduces Liver Enzymes

Naltrexone significantly reduces the elevation of serum glutamate-oxalacetate transaminase (SGOT) and glutamate-pyruvate transaminase (SGPT) (as index of hepatic function) induced by LPS.

Is LDN right for you?

The comments and posts you are reading saying how good they feel is because their immune status matches how LDN supports their imbalanced cytokines and chemokines. LDN works only for those with the correct immune status that Naltrexone or Naloxone supports.

If you do not match that cytokine or chemokine profile. LDN will only increase the damage and further disrupt your body’s ability to control the immune system. If you are using LDN and not satisfied with the way you are feeling. It is probably not right for you.

It is possible to get the immune system back under control. It is not a quick process but steady progress is experienced giving you the faith and confidence you need to know you did the right thing. One should never guess when it come to the immune system. Call today to have your Stimulated Cytokines and NEI Supersystem tested.

Are Edible Enemies contributing to poor health and inflammation? Lectins cause a plethora of damage to the body, promoting chronic inflammation and sensitivity. Take the Edible Enemy Quiz to test your knowledge on lectins.

Use the Lectin Control Formula to reduce the inflammatory response that occurs due to lectin consumption. Take two capsules with each meal.

Have You Weathered A Cytokine Storm?

Cytokine Storms occur when the immune system becomes and remains activated against the immune stimulants beyond the point of being helpful.

Many of the Professional and Social Media Influencers generically refer to Cytokine Storms as “Inflammation”. It was only after the Coronavirus Pandemic that Cytokine Storms have begun to be mentioned by these same Professional and Social Media Influencers. Similarly to medical intuitive psychics will always find in their patrons the current Diagnosis du jour. I question if they are so forward thinking, cutting edge or intuitive, why they did not take it upon themselves to research Cytokine Storms prior to the Coronavirus Pandemic.

How do they separate the Immune Response from Inflammation?

After being granted carte’ blanc lab testing privileges with complex neurotransmitter, hormone and stimulated cytokine panels. I became aware that most of the autoimmune cases were experiencing Cytokine Storms. Most patients had a history of taking “Immune Stimulating” supplements and/or Immune Suppressing Drugs without success. They are “Symptom Free” but feel like crap, resulting in Cytokine-Induced Sickness Behavior (see more below).

Too many people think symptom suppression using Green Allopathy (Supplements) and Allopathy (Drugs) is healthy.

I researched and cross-referenced every neurotransmitter, hormone and immune messenger on my own initiative. This was met with considerable resistance from my colleagues. Many of whom asked if I had permission to do that. (Yes, some really did ask that.) Others asked if I had shown it to the Professional or Social Media Influencers to validate the information. Initially, I did. Only to find them publishing the information as their own.

Cytokine Storms?

Chances are you have if you are suffering from Hashimoto’s, autoimmune conditions or a confusing mess of symptoms, you may be experiencing your very own Cytokine Storm season where you will have bad days followed by calm days after the storm and again by bad days. You may have found yourself in the proverbial “up a creek without a paddle” in your autoimmune world.

All Components of the NEI Supersystem – including Cytokines and Chemokines are Dose-Dependent

A good defense against most illness is a healthy immune system. We all know how a mother bear protects her cubs. At the first hint of danger she takes action to protect them in much the same way as our immune system seeks to protect us. We have been conditioned to think of external microbes as our enemy during a time of infection or inflammation.

Professional and Social Media Influencers talk about “Inflammation” and “Immune Response” as if they are disconnected and two separate issues in the body.

But our own immune systems are potentially more lethal. When the body detects foreign microorganisms or substances, it can respond by overprotecting the site of that irritation. In its hurry to get antibodies to the infection site, the body may dispatch so many that the level of cytokines becomes highly elevated, creating a Cytokine Storm.

If you are on the “Immune Stimulated” side of the scale? Is stimulating your immune system a good thing?

Antibody Testing

The current dogma is that Immune cells are stimulated by Antibodies. They believe as long as antibodies are present, the antibodies are constantly stimulating an immune response. They also are lead to believe the presence of antibodies are from an ongoing infection. Typically, IgG antibodies are produced in the first phase of immune responses. However, the immune response to IgA, IgG, and IgM declines or is terminated along the course of the disease in most patients. IgM antibodies are indicative of an ongoing immune response., Studies have shown the detection of IgA and IgM antibodies in 62% and 61% of IgG antibodies in autoimmune patients, and after 7 years.,

A resolution of the disease is not associated with a decrease in antibodies. Only those with a short disease duration are likely to experience a decrease in antibodies levels. For most autoimmune patients there is no significant change in antibody levels, However, patients with immune calming/quieting treatment, experienced a 20% decline in their antibody levels. Normalization in the levels of antibodies with treatment intervention occurs in less that 7% of patients. The success of clinical interventions in lowering antibody levels (and thus likely minimizing the pathogenic effects of autoantibody binding) appears to be dependent on disease duration. The association of shorter disease duration with greater declines in antibody levels is highly consistent with the growing body of evidence that shows improved clinical outcomes with earlier disease intervention in autoimmunity.,,

Approximately one-half of patients with Rheumatoid Arthritis had positive IgM-RF and/or antibodies on at least 1 occasion, almost 5 years prior to disease onset. More than 50% of autoimmune patients may have positive antibodies upwards of 13 years after disease resolution, regardless of treatment.

Cytokine Storms

“Storm” is an appropriate metaphor because it acknowledges a variety of mechanisms in a variety of circumstances. A Cytokine Storm is a symptomatic condition which occurs in varying forms and involves a number of different mechanisms. The primary symptoms of a Cytokine Storm are extreme fatigue, low mood, anxiousness, anxiety, insomnia, high fever, intermittent hot flashes, swelling and redness, and nausea. You may be more familiar with a Cytokine Storm known as Septic Shock, which is another example of the immune system gone berserk.

Cytokine Storms occur when the immune system becomes and remains activated against the immune stimulants or physical triggers (food, toxins, bacteria, virus, parasite, etc.) beyond the point of being helpful to where the immune response turns damaging or deadly. Researchers in Psychoneuro-immunology are now reporting emotional events can be a trigger as well. Cytokines are not simply immune, but rather neuro-immune modulators. The nervous system regulates immune cells and the magnitude of an immune response via the effects of peripheral neurotransmitters such as epinephrine, nor-epinephrine, dopamine, 5-hydroxytryptamine, acetylcholine, histamine and neuropeptides. The manner in which the cytokines are stimulated and balance between the inhibitory and stimulatory neurotransmitters determine the intensity of a Cytokine Storm.

Anti-Inflammatory Drugs work by “Suppressing” the immune response. Natural anti-inflammatories work by calming the immune response.

Persistent, highly elevated levels of pro- and anti-inflammatory cytokines induce a complex, dysregulated condition resulting in massive inflammation and fluid accumulation, blood flow dysfunction and eventually tissue destruction. Thus, in Cytokine Storm, the body’s immune system fights to rid itself of the immune stimulant, but the fight somehow escapes from the normal regulatory controls that should have prevented an overzealous immune system from severely damaging or killing its owner.

After the storm has passed: Cytokine-Induce Sickness Behavior

No matter the Medical specialty, they will be technically correct in their fields diagnosis.

After the Cytokine Storm has subsided, sick individuals have common symptoms of sickness; little motivation to eat, withdrawal from normal social activities, fever, burning muscles, aching joints,  fatigue and have significant changes in sleep patterns. They display an inability to experience pleasure, have exaggerated responses to pain and brain fog. Pro-inflammatory cytokines acting in the brain cause sickness behaviors. Although Functional Medicine has defined pro-inflammatory cytokines as the central mediators of sickness behavior, each patient exhibits unique circumstances. Specialized lab testing provides a scientific understanding of how cytokines and neurotransmitters are communicating with each other.

Why is IL-10 (an anti-inflammatory cytokine) severely increased with Anaphylaxis and Anaphylactic Shock? It is “Dose-Dependent”. Low levels do one thing. High levels are Pro-Inflammatory.

What’s Next?  

Calming a Cytokine Storm  and regulating cytokine induced sickness requires a multiple focus approach involving cytokines, neurotransmitters, quenching inflammation, re-regulating the immune system and elimination of any potential triggers. It is crystal clear that there must be negative feedback loops in the immune system, as well as positive ones. The latter enable the system to react quickly to serious infections. The former are needed to keep the system itself from spiraling out of control.Concerned about the possibility of an Autoimmune condition affecting your Health?

Call today! 530-615-4083

All neurotransmitters, hormones and immune messengers of the Neuro-Endo-Immune Supersytem are Dose-Dependent.

Neuro-endo-immunology is an emerging field of medical science that seeks to understand the interconnectedness of the nervous, endocrine, and immune systems functioning as a larger whole, termed the “NEI Supersystem.” In order to regulate cytokine induced sickness, you need to find a doctor that has a working knowledge of Neuro-endo-immunology, cytokines and neurotransmitters. Most are found only in labs and are not practicing healthcare providers.

Here are some questions to discuss with your practitioner. 

  • What is a Cytokine Storm?
  • How is TH17 involved in the TH1/TH2 challenge?
  • Do you use lab testing or supplement challenges to determine treatment protocols?
  • What are the different supplements used to challenge your condition?
  • What lab testing do you use?
  • How would they treat your condition?
  • Do they use Stimulated Cytokine or Neurotransmitter testing?

Researchers and most physicians agree that peripheral neurotransmitters impact the brain, especially during a cytokine storm. To date, neurotransmitter testing shows only peripheral neurotransmitters. But imagine you were trying to understand someone who was speaking in a language for which you only knew 17 words! Nonetheless, if you heard the words “danger”, “help”, and “fire”, you would have a decent idea as to the meaning of the message. Similarly, perturbations in the cytokines that we are able to find in the Stimulated Cytokine testing are extremely useful as indicators of the patient’s immune status, or to use the more formal lingo, they are biomarkers of the immune system. Unfortunately, many accomplished Neurologists remain too “brain-based” and overlook the impact neurotransmitter in the body have on the body.

TH1/TH2 Challenge and More

Despite its seductive simplicity, the Th1/Th2 model does not adequately explain T-cell immunity. Many cytokines produced by T-cells do not fit obviously into either category. Recent studies have shown exposure to lectins or bacteria trigger T-cells to produce IL-6, IL-17, and GM-CSF, cytokines not associated with either the Th1 or the Th2 immune system. This has begun an explosion of interest in the generation and function of “Th17” immune system that has not shown signs of tapering off.

Are Edible Enemies contributing to poor health and inflammation? Lectins cause a plethora of damage to the body, promoting chronic inflammation and sensitivity. Take the Edible Enemy Quiz to test your knowledge on lectins.

Use the Lectin Control Formula to reduce the inflammatory response that occurs due to lectin consumption. Take two capsules with each meal.

When combined with a strong inflammatory cytokine such as TNFα, interleukin 17 (IL-17) triggers a severe inflammatory response. TNFα was thought to provoke only a TH1 response. Curiously, the ability to control the activity of IL-17 is relatively poor. It’s like being pregnant; once it has started you are just along for the ride.

It is not so simple as “stimulating the immune system”.

Case example: We had one case where the doctor used Supplement challenges to determine the treatment. First, they did the GABA challenge. The patient felt great but was put on acetylcholine support and immediately crashed in a cytokine storm. Doctor said it was the flu. Next, they used (Gastro-ULC) making the patient feel better. Doctor stopped that and supplemented with digestive enzymes making the patient crash again. The doctor explained it as a “Healing crisis”. Patient came to our office for help.

Be wary of provoking immune responses. Those having bad reactions to the TH1/TH2 challenge are provoking a Cytokine Storm. Normally, the TH1/TH2 feedback loop is kept in check by the body. However, in some instances, when purposely provoked, the reaction becomes uncontrolled and too many immune cells are activated, much like pouring gas on a fire. This propagates a Cytokine Storm where far too many immune cells are caught in an endless loop of calling more and more immune cells to fight the irritation.

Those who have experienced a Cytokine Storm and have cytokine induced sickness should avoid, herbs and foods, which boost the immune response. TH1 boosters are astragulus, echinacea, goldenseal, immune boosting mushrooms. TH2 boosters are caffeine, green tea, grape seed extract, pine bark extract, and lycopene. Sambucol (which is Elderberry juice), Chlorella algae, Spirulina, Chocolate, Kimchi and Honey are additional foods that can increase cytokine production and should be avoided during a Cytokine Storm. These foods are good for treatment of less severe colds and flu, when the immune response appropriately regulated, but should be avoided when symptoms are being caused by a cytokine storm. Symptoms of a cytokine induced episode vary greatly from individual to individual. A limited list of symptoms are extreme fatigue, low mood, anxiousness, anxiety, insomnia, high fever, intermittent hot flashes, swelling and redness, and nausea.

Cytokine Storms are very serious and with the right set of circumstances can be fatal. If the storm is concentrated in the lungs and airways, the mucus and inflammation has the potential to block airways and result in death. This is recognized as a Type II hypersensitivity allergic reaction and only an Immunologist would connect cytokines with it. Many believe that the Cytokine Storm response was what caused the deaths of so many young adults in the 1918 Influenza Pandemic. New research and understandings have caused some to question vaccinations, especially three-stage vaccinations.

More about Stimulated Cytokine testing?

Stimulated Cytokine testing is intended to assess whether an individual’s symptoms could be attributed to an imbalanced immune response. Our goal is to understand, as best we can, where to target therapeutic interventions, minimizing emotional decisions and guesswork in the therapeutic protocol.

It’s important to note that the standard immune testing by itself cannot distinguish between an immune response that is currently in progress, and one that happened in the past. That’s because it cannot tell the difference between so-called “effector” T cells that are currently fighting an active infection, and “memory” T cells that responded years ago to a prior infection and continue to circulate in the bloodstream.

However, at the same time it’s important to recognize that even a test that measures up to 17 cytokines, as NeuroScience Stimulated Cytokines Comprehensive panel does, is far from actually being “comprehensive”, considering that over 100 cytokines have been described to date!

The Best Option

The Neuro-Endo-Immune (NEI) Supersystem incorporates three vital disciplines: Neurology, Endocrinology, and Immunology, which is the evaluation of the NEI Supersystem through the measurement of neurotransmitters, hormones, and cytokines. Assessment of these essential biochemical mediators provides important insight into the root causes contributing to clinical conditions of a Cytokine Storm and cytokine induced sickness.

Concerned about your Health?

Call today! 530-615-4083