How Should Doctors Treat Adrenal Fatigue?

If you want to change the fruits, you will first have to change the roots. If you want to change the visible, you must first change the invisible. – T. Harv Eker

It’s frustrating to have persistent symptoms your doctor can’t readily explain. Adrenal fatigue is a term applied to a collection of nonspecific symptoms, such as body aches, fatigue, and nervousness, sleep disturbances and digestive problems. The term often shows up in popular health books and on alternative medicine websites, but it isn’t an accepted medical diagnosis unless it is diagnosed as Addison’s disease.

Proponents of adrenal fatigue seldom recognize adrenal dysfunction is always secondary to other physiological mechanisms 

What are the adrenals? Think of them as the caring grandma. She will not sit down when the family is together until everyone is seated at the table and all are served. But before she sits down, she has to clear the dishes, make coffee and serve dessert. Then she has to wash the dishes, clean the kitchen and make snacks. She’s fatigued because she is always trying to take care of everybody. She is an enabler to a dysfunctional family. Do you think she would be so fatigued if family members would stop bickering long enough to pitch in and help?

Concerned about your Health?

Call today! 530-615-4083

This is not a case where the Alternative medicine community knows something the Medical community does not. While it is true the Medical community does not recognize adrenal fatigue. The Functional Medical community has followed the adrenal fatigue paradigm. This off recognizes other factors are involved because neurotransmitters are tested at the same time as the adrenals. As a result of this, those with ‘failing adrenals’ on the never-ending adrenal program respond to the neurotransmitter support.

Adrenal testing is the “Low-Hanging Fruit” of the Alternative medicine community. 

Adrenal testing is the “Low-Hanging Fruit” of the Alternative medicine community. Adrenal tests do not require a lot of effort and will almost always show adrenal fatigue, like testing the air pressure in a flat tire.

The adrenal glands, located on top of the kidneys, produce a number of hormones and neurotransmitters, including cortisol, noradrenalin, adrenaline – the three main stimulatory neurotransmitters, dopamine – a neurotransmitter and stress hormone precursor, DHEA, aldosterone, estrogen, and testosterone in addition to the little know – eticholanolone – the inflammation hormone. Dopamine, norepinephrine and epinephrine are classified as Catecholamines, which are tyrosine-based stress neurotransmitters produced by the adrenal glands during times of psychological stress or low blood sugar levels’.

Melatonin will not work for interrupted sleep for those with low cortisol levels. Low cortisol levels will allow a person to go to sleep and wake up later during the night. Melatonin suppresses cortisol levels and makes adrenal hormone receptor sites more sensitive. Melatonin would work best for those who simply cannot go to sleep.

Cortisol is a corticosteroid hormone produced in the adrenal cortex (part of the adrenal gland). It is commonly known as the primary ‘stress hormone’. It is involved in the response to anxiety and stress, controlled by the Corticotrophin-releasing hormone produced in the pituitary. Elevated cortisol levels tend to increase blood pressure and blood sugar, and reduce the immune responses/capability. Compared with the neurotransmitter adrenaline, it is very slow acting, in neurological terms. Adrenaline can be released in a small fraction of a second, whereas cortisol requires a whole second to be secreted. Cortisol tends to be more implicated in the long term fight or flight response that afflicts those with long term stress, e.g. autoimmune conditions. Of course, overproduction of cortisol through extended periods of stress will result in adrenal burnout and the eventual underproduction of cortisol and other adrenal hormones.

There are many other factors contributing to the stressing of the adrenals glands and impaired neurotransmitter production in general, such as impaired Dopamine/GABA and Serotonin pathways and energy production, excessive Glutamate and Aspartate intake (results in excitotoxicity and disrupts brain chemistry), excessive free radicals, psychological and physical stress, high carbohydrate diet (especially sugar), nutritional deficiencies, inadequate digestive and amino acid conversion processes, prolonged periods of hunger between meals (3 large, square meals a day approach), recreational/legal drug use (caffeine, alcohol, certain anti-depressants, marijuana, speed, meth, cocaine etc.), and birth control pills etc.

For example, it is very difficult to improve adrenal function if a person is anemic. They will not be able to deliver oxygen to mitochondria for ATP energy production and will be dependent upon glycolosis for energy production. Glycolosis is inefficient and places great demands upon the blood sugar/adrenal stabilizing system. The symptoms of any of the thirteen types of anemia are identical to those of adrenal fatigue.

The use of simplified protocols and models to support adrenal disorders are self-limiting. Adrenal dysfunction is always secondary to other physiological mechanisms that need to be identified. The following physiological mechanisms are the root causes preventing the adrenals rehabilitation:

  • Anemia
  • Dysglycemia
  • Low cholesterol
  • Infection
  • Increased intestinal permeability
  • Surgical menopause
  • Dehydration
  • Inflammation
  • Immune Dysregulation
  • Excess Pro-inflammatory cytokines
  • Deficient Inhibitory neurotransmitters
  • Depression medication
  • Emotional stress
  • Autoimmune
  • Heavy metal due to DMT1 upregulation from inflammation/immune dysregulation
  • Environmental antigen burden

– Case Studies & Principles, page 90-91, D. Kharrazian, Author of Why Do I Have Thyroid Symptoms? When My Lab Tests Are Normal.

Are the adrenals involved? Absolutely, but the best way to support them is by correcting the physiological mechanisms causing them to fatigue. The major factor behind adrenal fatigue is usually a Neuro-Endo-Immune system imbalance.

The Neuro-Endo-Immune (NEI) Supersystem incorporates three vital disciplines: Neurology, Endocrinology, and Immunology. Evaluation of the NEI Supersystem – through the measurement of neurotransmitters, hormones, and cytokines – nervous, endocrine, and immune function, are represented respectively. Assessment of these essential biochemical mediators provides important insight into the root causes contributing to adrenal fatigue. The Neuroscience NeuroEndocrine Comprehensive should be utilized to simultaneously measure adrenal hormones, cortisol, DHEA, neurotransmitters and hormones. The NeuroEndocrine Comprehensive profile includes additional neurotransmitter metabolites, DOPAC and 5-HIAA, to assist in assessing serotonin and dopamine activity. It also includes the addition of the amino acid taurine, which is useful in confirming the extent of the stress response.

One way to develop a plan to correct adrenal fatigue is to measure neurotransmitter precursors using the Metametrix Triad Profile. The TRIAD Profile targets each persons specific needs by integrating three powerful profiles – Organix, Amino Acids, and Allergix IgG Food Antibodies – into a single innovative test offering customized intervention options.

The interrelationship of the biochemical processes between the adrenals, different neurotransmitters and hormones involve extremely complex systems of the body: endocrine system, exocrine system, hormonal regulation, immune system, neurological system and brain chemistry. It is extremely complex and finely balanced. Too much or too little of any system can be very detrimental to the body.

Neurotransmitter and hormones must be evaluated. Patients with similar symptoms can have remarkably different metabolic and nutritional needs. Patients with comparable laboratory results often exhibit widely divergent symptoms.  Adrenal fatigue can be measured and corrected by specific testing.

Are you interested in having your adrenals checked? I invite you to call today to set up your adrenal test.

Concerned about your Gastrointestinal Immune Health or Autoimmune Disease? 

Concerned about your Health?

Call today! 530-615-4083

Melatonin Suppresses Thyroid Hormones

The hypothalamic-pituitary-thyroid axis (HPT axis) is a neuroendocrine system that regulates metabolism.  When the hypothalamus senses low circulating levels of the hormones T3 and T4, it signals to the pituitary, which then signals the thyroid gland to release T3 and T4.  T4 normally is converted to the more active T3, but T4 can also be converted to reverse T3 (rT3).  Reverse T3 works against the T3 receptor, so high levels can be detrimental.

HPT melatonin
Melatonin supplementation inhibits the TSH content in the pituitary. However, Melatonin supplementation blocks the stimulatory effect of TSH on thyroid cells responsible for the production and secretion of thyroid hormones thyroxine (T4) and triiodothyronine (T3).

During illness, profound changes may occur in the hypothalamic-pituitary-thyroid (HPT) axis. The most consistent change is a decrease in serum tri-iodothyronine (T3) level, but in severe illness, thyroxine (T4) may also decrease. The persistence of a normal or even decreased level of thyrotropin (TSH) in the face of decreased serum thyroid hormone concentrations implies a major change in HPT axis set-point regulation. Since these abnormalities of thyroid hormone concentration usually occur without any evidence of thyroid disease and disappear with recovery, they have been referred to as the `sick euthyroid syndrome’ or the `euthyroid sick syndrome’.

TSH serum levels are lower and those of free T4 are greater at night, when melatonin levels are higher, so that the response of pituitary to hypothalamic TRH and of thyroid to pituitary TSH is influenced by the pineal hormone melatonin, which alters the hypothalamic-pituitary-thyroid (HPT) axis function. Melatonin drives the molecular clockwork in the pituitary.

Melatonin & Thyroid Function

Melatonin has a suppressing action on thyroid function. Both hypothyroid and thyrotoxic patients have disturbed pineal function, which is not the case in those with weight issues. Those with hypothyroidism were found to have higher peak melatonin levels, total nighttime melatonin secretion, and urinary elimination of melatonin than normal individuals. Although thyrotoxic patients released a normal amount of melatonin during the night, their melatonin secretion peak occurs earlier in the night.

The molecular clockwork in the pituitary is strongly dependent on melatonin. Melatonin drives the rhythmic expression of clock genes in the pituitary, and the length of daytime light as well as melatonin supplements are involved in melatonin signaling.

Melatonin plays a role in the regulation of TSH release from the pituitary. Short days and long nights are correlated with decreasing levels of TSH in the pituitary. Moreover, chronic treatment with melatonin suppresses TSH release from the pituitary.

Melatonin has an inhibitory action on the Hypothalamic-pituitary-thyroid (HPT) axis. Long nights result in reduced levels of circulating thyroxin (T4). An active pineal gland produces melatonin, which inhibits thyrotrophin-releasing hormone (TRH) release from the hypothalamus. The effects of melatonin on the Hypothalamic-pituitary-thyroid (HPT) axis are similar to its effects on the Hypothalamic-pituitary-gonadal (HPG) axis.

Melatonin supplementation inhibits the TSH content in the pituitary. However, Melatonin supplementation blocks the stimulatory effect of TSH on thyroid cells responsible for the production and secretion of thyroid hormones thyroxine (T4) and triiodothyronine (T3). Free T3, T4 and TSH levels are lower with melatonin supplementation.

Melatonin is Not Just for Sleep Anymore

While most consider melatonin to be only produced by the pineal gland. It is produced throughout the body in much greater quantity (400x more in the gut). Melatonin is much more involved than previously thought. From enhancing autoimmune flairs during cytokine storms, to playing a role with infertility, melatonin and melatonin supplements used for ‘sleep problems’ enhances these conditions and not in a good way. It even plays a role in hot flashes and night chills.

If you have questions about sleep and you are having thyroid, autoimmune or infertility concerns with your health. Please contact my office.

Mitochondrial Syndrome

Chronic Fatigue is a common complaint but I don’t have to tell you that. It has been given syndrome status as Chronic Fatigue Syndrome (CFS). Somebody starts blaming the mitochondria, which has now become Mitochondrial Syndrome. Let me translate “syndrome.” It is Doctor speak for “we don’t know but lump these symptoms together and give it a name.” There is a common meme on the Internet is to blame components of the mitochondria, listing 18 different different types of Mitochondropathy.

Mitochondria are the body’s cellular power plants. Why isn’t it generating power? Just as any power generators require fuel. The “fuel” for mitochondria is glucose and oxygen. Growing up on a farm, you learn the first question to ask is – is it out of fuel. Sometimes, it is that simple. So I checked the Professional Influencers websites to find out if they were checking the fuel for mitochondria. Do a simple ‘Ctrl F’ on their sites and type in glucose or oxygen. I was surprised to see none of them are bothering to check the fuel. Most are copy and paste – posting identical information. A couple of the sites mention oxygen during description of the mitochondrial components. But not as a requirement for mitochondrial production of energy.

On the farm, you learn to check the fuel in the tractor before tearing apart the generator. If you are using solar, check where the sun is. Is it cloudy? The Professional Influencers start tearing apart the mitochondria and recommending supplements with convenient links to sales pages, much like the repair shop selling new spark plugs. New spark plugs will not work if there is no fuel. Solar is probably closest to Mitochondria energy production.

Changes in blood flow, pH and metabolic function all play roles in the delivery of glucose and oxygen. Just as the sun moving across the sky changes the angle of the sun to the solar panel, clouds, and nighttime, all playing a role in how much power a solar panel will generate. Movement, blood flow and the stickiness of the Red Blood Cells (RBCs) play a role in the delivery of oxygen and glucose to the mitochondria. Insulin resistance (Pre-diabetes) makes RBCs stick together. It gets worse with Diabetes. To get the most output, everything must come together to deliver the maximum amount of fuel for both solar and mitochondria energy production.

Mitochondria rely on the blood to deliver glucose and red blood cells ability to carry and deliver oxygen. Do not assume, just because a blood vessel runs past the cells that oxygen and glucose are being delivered.

Conditions such as Insulin Resistance or Metabolic Syndrome alter both the delivery of oxygen and glucose. These are fairly simple to reverse and have fallen out of favor with the Professional and Social Media Influencers. They are not lucrative enough.

Pre-diabetes & Insulin Resistance

What is insulin?

Insulin is a hormone made in the pancreas, an organ located behind the stomach. The pancreas contains clusters of cells called islets. Beta cells within the islets make insulin and release it into the blood.

Insulin plays a major role in metabolism—the way the body uses digested food for energy. The digestive tract breaks down carbohydrates—sugars and starches found in many foods—into glucose. Glucose is a form of sugar that enters the bloodstream. With the help of insulin, cells throughout the body absorb glucose and use it for energy.

Insulin resistance is associated with low-grade inflammatory response. Insulin resistance is associated with an enhanced degree of Red Blood Cell (RBCs) adhesiveness/aggregation. Vascular complications are common in subjects with ‘metabolic syndrome’, insulin resistance as a result of RBCs sticking together. There is a significant correlation exists between the degree of RBC adhesiveness/aggregation and the degree of insulin resistance and that of inflammation.

Insulin resistance is associated with an accelerated formation of a blood clumping within an artery. An enhanced inflammatory response exists in individuals with the insulin-resistance syndrome, which is related to the development of atherosclerosis and positive ANA antibodies. RBC clumping is detrimental to capillary blood flow and tissue oxygenation for the mitochondria.

But Doctor, I don’t fit the picture for insulin resistance. I understand you don’t fit the exact picture for insulin resistance. You also don’t fit the exact picture for low thyroid, Lyme Disease, or whatever condition you are being treated for. But that didn’t stop them from diagnosing you and treating you for that condition.

What happens with insulin resistance?

The consequences of insulin resistance are twofold. 1) RBC sticking together impairing blood flow and delivery of oxygen and glucose. 2) impaired delivery of glucose into the cells of the body.

In insulin resistance, muscle, fat, and liver cells do not respond properly to insulin and thus cannot easily absorb glucose from the bloodstream. As a result, the insulin receptors on the cells are not responding to the presence of insulin. The body needs higher levels of insulin to help glucose enter cells. This puts added stress on the 1% (endocrine) of the pancreas responsible for producing insulin. With insulin resistance, it’s as if insulin is knocking on the door, but the cells can’t hear it. The pancreas responds by pumping out even more insulin (knocking louder) in an effort to get glucose into the cells, and this eventually causes Type 2 diabetes.

The beta cells in the pancreas try to keep up with this increased demand for insulin by producing more. As long as the beta cells are able to produce enough insulin to overcome the insulin resistance, blood glucose levels stay in the healthy range.

This is made difficult by the 99% (exocrine) of the pancreas producing digestive enzymes. Without stomach acid, enzymes are trapped in the pancreas. No – betaine HCl supplements are not the same as stomach acid. The stomach does not produce “betaine” HCl. The proper quality and quantity of stomach acid stimulates hormone release in the small intestine to signal the pancreas to release the enzymes. Trapped in the pancreas, enzymes are activated and begin digesting the unprotected insulin producing endocrine cells of the pancreas. Then quantity control of insulin suffers as the pancreas is auto-digested.Why Doctors Miss the Initial Warning Sign of Insulin Resistance

Doctors have been trained to measure a person’s fasting blood sugar, or the glucose levels present in your blood, at least eight hours after your last meal. Most don’t express concern until results show blood sugar levels reaching 110 mg/dl “and” you have the proper body type. You can be thin and have insulin resistance. That’s when they start “watching it.” Then, once your blood sugar reaches 126 mg/dl, your doctor will diagnose you with Pre-diabetes. Thus preparing you for the meme of a life-long disease. That is if they ever consider insulin resistance when there are so many other conditions that have the same ubiquitous symptoms.

Single markers should never be used for a diagnosis, i.e. glucose – insulin resistance, TSH – Thyroid, etc.

Markers for Insulin Resistance include:

  • Glucose
  • Cholesterol
  • Triglycerides
  • LDL
  • HDL
All things considered. This Patient has a preponderance of markers for insulin resistance.

The important thing to note is that blood sugar is the last thing to increase…so for many people, a fasting glucose test detects insulin resistance too late. For some, their digestion is so poor their blood sugar is never high. I have seen so many Professional and Social Media posting with their new glucose meters and how they are checking their blood sugar throughout the day. There is usually for only one or two posts and these Toy Collectors are on the next thing.

Delivery of Glucose

Insulin resistance is accompanied by impairment in the ability of insulin to deliver glucose to the cells and in turn the mitochondria.

Red blood cell agglutination occurs as a result of insulin resistance. Blood cell agglutination results in hypoxia/hypercapnia causing mitochondrial dysfunction

Insulin Resistance/Diabetes causes blood to be hyper-viscous and increased red blood cell agglutination, which lead to severe microcirculation disturbance, osteoporosis, hyperlipemia, imparing the delivery of both oxygen and glucose.

Delivery of Oxygen

If there’s one thing that mitochondria thrive on, its oxygen. Mitochondria require oxygen and glucose to produce ATP in sufficient quantities to drive energy-requiring reactions. Oxygen carrying molecules, such as hemoglobin and myoglobin are necessary to transport oxygen to where it is needed.

In “normal” conditions, Oxygen bound to hemoglobin in the blood diffuses down a steep pressure gradient into tissues as blood travels through capillaries. Next oxygen diffuses into the mitochondria.

As blood flows through the capillaries in our metabolizing tissues, oxygen diffuses out of the red blood cells.

Areas of high turbulence in the vasculature accelerate the release of oxygen from hemoglobin. In the circulation, there is no specific barrier to oxygen diffusion in the blood vessels that prevents oxygen exit. As a consequence, oxygen continuously diffuses out of the red blood cell, in the same way that the delivery of water transported by a leaky bucket is a function of how fast the bucket is carried. Red blood cells become hypoxic (oxygen deficient) after passing through turbulence until their next pass through the lungs. Hypoxic red blood cell pass by downstream tissues and mitochondria leaving them in a hypoxic state. The farthest areas of the body – brain, hands and feet are the most prone to being hypoxic.

Hypoxia Deactivates Mitochondria

Hypoxia deactivates Mitochondria. Hypoxia causes mitochondria to deactivate going into a dormant state. Let’s get this straight. Not all Mitochondria are shut down simultaneously. That would be death. What would a 15%, 25% or 50% deactivation of Mitochondria do to your energy levels?

What Mitochondria supplement will reactivate the mitochondria being deprived of oxygen? Of course the Mitochondria are not working. They can’t without their fuel – glucose and oxygen.

Doctor can’t I jump in a hyperbaric chamber or use a oxygen concentrator? Yes. Those will increase the oxygen in the body. But not enough to restore your energy. At best, these are a temporary quick fix, somewhere on the lines of a high interest payday loan. Especially when the red blood cell agglutination caused insulin resistance has not been dealt with.

Do the math:

  • Mitochondria with adequate oxygen and glucose produce 38 ATPs.
  • Mitochondria with adequate glucose but lacking oxygen produce 2 ATPs.
  • Mitochondria without oxygen and glucose produce Zero ATPs and deactivate going into power saver mode.

Supplements supporting the Mitochondria drive those that are still active to work harder with less glucose and oxygen. This causes them to age prematurely. Yes, Mitochondria do age and need to be replaced.

Bone Marrow Fatigue Results Production of Damaged Red Blood Cells

Inflammation is part of the healing process for wounds and infections. Inflammation is a normal immune system response that functions to protect the body from infection and diseases. During inflammation, white blood cells and other body chemicals attempt to remove any potentially harmful substances from the body.

Symptoms vary depending on the individual and the severity and time the bone marrow has been overworked. Symptoms may include:

  • Tiredness, or fatigue
  • Weakness
  • Excessive bleeding
  • Pinpoint red spots on the skin caused by bleeding from small blood vessels
  • Easy bruising
  • Frequent infections
  • Fevers
  • Pale skin
  • Shortness of breath

The body is set up for short sharp bursts of inflammation, to combat microbial, mechanical or chemical insults. The whole point is to generate enough inflammation to combat the threat through (stimulatory neurotransmitters, inflammatory cytokines & chemokines, white blood cells and the sympathetic nervous system) and then cool, repair and close up the area of injury ending the inflammation through (inhibitory neurotransmitters, anti-inflammatory cytokines and chemokines, white blood cells and the parasympathetic nervous system).

Disruption of the NEI Supersystem through long-term stress and the ingestion of inappropriate foods and chemicals irritation create a state of chronic inflammation. Our immune system can become fatigued, working at a low level, no longer able to generate enough energy for full protection, but still causing on going cell damage through low-grade inflammation. We become both depleted of certain white blood cells and others continue to maintain the inflammation. Then add to the fatigue by overstimulating the immune system with immune boosting supplements. Read More …

Summarizing Chronic Fatigue and Mitochondriopathy

Symptoms of fatigue are attributed to disease conditions, e.g. thyroid, and about every other condition being diagnosed. Let’s start by checking the fuel first with Lab tests such as the Bio-Screen Sustain Max. Too many start with EBV antibodies that 90% (ninety percent) of the world’s population is positive for. Talk about low hanging fruit.

Call today if you suffer from chronic fatigue and are sick and tired of being sick and tired. 530-615-4083

Have You Weathered A Cytokine Storm?

Chances are you have if you are suffering from Hashimoto’s, autoimmune conditions or a confusing mess of symptoms, you may be experiencing your very own Cytokine Storm season where you will have bad days followed by calm days after the storm and again by bad days. You may have found yourself in the proverbial “up a creek without a paddle” in your autoimmune world.

Cytokine Storms occur when the immune system becomes and remains activated against the immune stimulants beyond the point of being helpful.

A good defense against most illness is a healthy immune system. We all know how a mother bear protects her cubs. At the first hint of danger she takes action to protect them in much the same way as our immune system seeks to protect us. We have been conditioned to think of external microbes as our enemy during a time of infection or inflammation. But our own immune systems are potentially more lethal. When the body detects foreign microorganisms or substances, it can respond by overprotecting the site of that irritation. In its hurry to get antibodies to the infection site, the body may dispatch so many that the level of cytokines becomes highly elevated, creating a Cytokine Storm.

“Storm” is an appropriate metaphor because it acknowledges a variety of mechanisms in a variety of circumstances. A Cytokine Storm is a symptomatic condition which occurs in varying forms and involves a number of different mechanisms. The primary symptoms of a Cytokine Storm are extreme fatigue, low mood, anxiousness, anxiety, insomnia, high fever, intermittent hot flashes, swelling and redness, and nausea. You may be more familiar with a Cytokine Storm known as Septic Shock, which is another example of the immune system gone berserk.

Cytokine Storms occur when the immune system becomes and remains activated against the immune stimulants or physical triggers (food, toxins, bacteria, virus, parasite, etc.) beyond the point of being helpful to where the immune response turns damaging or deadly. Researchers in Psychoneuro-immunology are now reporting emotional events can be a trigger as well. Cytokines are not simply immune, but rather neuro-immune modulators. The nervous system regulates immune cells and the magnitude of an immune response via the effects of peripheral neurotransmitters such as epinephrine, nor-epinephrine, dopamine, 5-hydroxytryptamine, acetylcholine, histamine and neuropeptides. The manner in which the cytokines are stimulated and balance between the inhibitory and stimulatory neurotransmitters determine the intensity of a Cytokine Storm.

Persistent, highly elevated levels of pro- and anti-inflammatory cytokines induce a complex, dysregulated condition resulting in massive inflammation and fluid accumulation, blood flow dysfunction and eventually tissue destruction. Thus, in Cytokine Storm, the body’s immune system fights to rid itself of the immune stimulant, but the fight somehow escapes from the normal regulatory controls that should have prevented an overzealous immune system from severely damaging or killing its owner. Read more about My Cytokine Storm

After the storm has passed: Cytokine-Induce Sickness Behavior

After the Cytokine Storm has subsided, sick individuals have common symptoms of sickness; little motivation to eat, withdrawal from normal social activities, fever, burning muscles, aching joints,  fatigue and have significant changes in sleep patterns. They display an inability to experience pleasure, have exaggerated responses to pain and brain fog. Pro-inflammatory cytokines acting in the brain cause sickness behaviors. Although Functional Medicine has defined pro-inflammatory cytokines as the central mediators of sickness behavior, each patient exhibits unique circumstances. Specialized lab testing provides a scientific understanding of how cytokines and neurotransmitters are communicating with each other.

What’s Next?  

Calming a Cytokine Storm  and regulating cytokine induced sickness requires a multiple focus approach involving cytokines, neurotransmitters, quenching inflammation, re-regulating the immune system and elimination of any potential triggers. It is crystal clear that there must be negative feedback loops in the immune system, as well as positive ones. The latter enable the system to react quickly to serious infections. The former are needed to keep the system itself from spiraling out of control.

Concerned about the possibility of an Autoimmune condition affecting your Health?

Call today! 530-615-4083

Neuro-endo-immunology is an emerging field of medical science that seeks to understand the interconnectedness of the nervous, endocrine, and immune systems functioning as a larger whole, termed the “NEI Supersystem.” In order to regulate cytokine induced sickness, you need to find a doctor that has a working knowledge of Neuro-endo-immunology, cytokines and neurotransmitters. Most are found only in labs and are not practicing healthcare providers.

Here are some questions to discuss with your practitioner. 

  • What is a Cytokine Storm?
  • How is TH17 involved in the TH1/TH2 challenge?
  • Do you use lab testing or supplement challenges to determine treatment protocols?
  • What are the different supplements used to challenge your condition?
  • What lab testing do you use?
  • How would they treat your condition?
  • Do they use Stimulated Cytokine or Neurotransmitter testing?

Researchers and most physicians agree that peripheral neurotransmitters impact the brain, especially during a cytokine storm. To date, neurotransmitter testing shows only peripheral neurotransmitters. But imagine you were trying to understand someone who was speaking in a language for which you only knew 17 words! Nonetheless, if you heard the words “danger”, “help”, and “fire”, you would have a decent idea as to the meaning of the message. Similarly, perturbations in the cytokines that we are able to find in the Stimulated Cytokine testing are extremely useful as indicators of the patient’s immune status, or to use the more formal lingo, they are biomarkers of the immune system. Unfortunately, many accomplished Neurologists remain too “brain-based” and overlook the impact neurotransmitter in the body have on the body.

TH1/TH2 Challenge and More

Despite its seductive simplicity, the Th1/Th2 model does not adequately explain T-cell immunity. Many cytokines produced by T-cells do not fit obviously into either category. Recent studies have shown exposure to lectins or bacteria trigger T-cells to produce IL-6, IL-17, and GM-CSF, cytokines not associated with either the Th1 or the Th2 immune system. This has begun an explosion of interest in the generation and function of “Th17” immune system that has not shown signs of tapering off.

Are Edible Enemies contributing to poor health and inflammation? Lectins cause a plethora of damage to the body, promoting chronic inflammation and sensitivity. Take the Edible Enemy Quiz to test your knowledge on lectins.

Use the Lectin Control Formula to reduce the inflammatory response that occurs due to lectin consumption. Take two capsules with each meal.

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When combined with a strong inflammatory cytokine such as TNFα, interleukin 17 (IL-17) triggers a severe inflammatory response. TNFα was thought to provoke only a TH1 response. Curiously, the ability to control the activity of IL-17 is relatively poor. It’s like being pregnant; once it has started you are just along for the ride.

Case example: We had one case where the doctor used Supplement challenges to determine the treatment. First, they did the GABA challenge. The patient felt great but was put on acetylcholine support and immediately crashed in a cytokine storm. Doctor said it was the flu. Next, they used (Gastro-ULC) making the patient feel better. Doctor stopped that and supplemented with digestive enzymes making the patient crash again. The doctor explained it as a “Healing crisis”. Patient came to our office for help.

Be wary of provoking immune responses. Those having bad reactions to the TH1/TH2 challenge are provoking a Cytokine Storm. Normally, the TH1/TH2 feedback loop is kept in check by the body. However, in some instances, when purposely provoked, the reaction becomes uncontrolled and too many immune cells are activated, much like pouring gas on a fire. This propagates a Cytokine Storm where far too many immune cells are caught in an endless loop of calling more and more immune cells to fight the irritation.

Those who have experienced a Cytokine Storm and have cytokine induced sickness should avoid, herbs and foods, which boost the immune response. TH1 boosters are astragulus, echinacea, goldenseal, immune boosting mushrooms. TH2 boosters are caffeine, green tea, grape seed extract, pine bark extract, and lycopene. Sambucol (which is Elderberry juice), Chlorella algae, Spirulina, Chocolate, Kimchi and Honey are additional foods that can increase cytokine production and should be avoided during a Cytokine Storm. These foods are good for treatment of less severe colds and flu, when the immune response appropriately regulated, but should be avoided when symptoms are being caused by a cytokine storm. Symptoms of a cytokine induced episode vary greatly from individual to individual. A limited list of symptoms are extreme fatigue, low mood, anxiousness, anxiety, insomnia, high fever, intermittent hot flashes, swelling and redness, and nausea.

Cytokine Storms are very serious and with the right set of circumstances can be fatal. If the storm is concentrated in the lungs and airways, the mucus and inflammation has the potential to block airways and result in death. This is recognized as a Type II hypersensitivity allergic reaction and only an Immunologist would connect cytokines with it. Many believe that the Cytokine Storm response was what caused the deaths of so many young adults in the 1918 Influenza Pandemic. New research and understandings have caused some to question vaccinations, especially three-stage vaccinations.

More about Stimulated Cytokine testing?

Stimulated Cytokine testing is intended to assess whether an individual’s symptoms could be attributed to an imbalanced immune response. Our goal is to understand, as best we can, where to target therapeutic interventions, minimizing emotional decisions and guesswork in the therapeutic protocol.

It’s important to note that the standard immune testing by itself cannot distinguish between an immune response that is currently in progress, and one that happened in the past. That’s because it cannot tell the difference between so-called “effector” T cells that are currently fighting an active infection, and “memory” T cells that responded years ago to a prior infection and continue to circulate in the bloodstream.

However, at the same time it’s important to recognize that even a test that measures up to 17 cytokines, as NeuroScience Stimulated Cytokines Comprehensive panel does, is far from actually being “comprehensive”, considering that over 100 cytokines have been described to date!

The Best Option

The Neuro-Endo-Immune (NEI) Supersystem incorporates three vital disciplines: Neurology, Endocrinology, and Immunology, which is the evaluation of the NEI Supersystem through the measurement of neurotransmitters, hormones, and cytokines. Assessment of these essential biochemical mediators provides important insight into the root causes contributing to clinical conditions of a Cytokine Storm and cytokine induced sickness.

Concerned about your Health?

Call today! 530-615-4083

Bone Marrow Fatigue

Do you have low white blood cells?  Are you always feeling bad and constantly fatigued but never get “sick”? If this is you?  You may have Bone Marrow Fatigue.

Do you have hip or sciatic pain the goes away for a couple of days after a Chiropractic adjustment? But then comes back again. You may have Bone Marrow Edema.

Bone Marrow Fatigue

When you have a low blood count, this means your bone marrow is not making enough of one type of blood cells. Bone marrow is a sponge-like tissue inside the bones. It contains stem cells that develop into the three types of blood cells that the body needs:

  • Red blood cells carry oxygen throughout your body.
  • White blood cells fight infections.
  • Platelets stop bleeding.

It has long been known that cells that make red blood cells make up the bone marrow. However, knowledge that immune response begins within the bone marrow, in other words, that bone marrow is also a secondary lymphatic organ, is fairly recent. Under normal circumstances, various cells form within the bone marrow, including endothelial precursor cells (EPC), neutrophils (Nf) and dendritic cells (DC).

Chronic Inflammation

Inflammation is part of the healing process for wounds and infections. Inflammation is a normal immune system response that functions to protect the body from infection and diseases. During inflammation, white blood cells and other body chemicals attempt to remove any potentially harmful substances from the body.

The body is set up for short sharp bursts of inflammation, to combat microbial, mechanical or chemical insults. This inflammation happens locally at the site of injury, but is guided by the autonomic nervous system and the Neuro-Endo-Immune Supersystem. The whole point is to generate enough inflammation to combat the threat through (stimulatory neurotransmitters, inflammatory cytokines & chemokines, white blood cells and the sympathetic nervous system) and then cool, repair and close up the area of injury ending the inflammation through (inhibitory neurotransmitters, anti-inflammatory cytokines and chemokines, white blood cells and the parasympathetic nervous system).

Disruption of the NEI Supersystem through long-term stress and the ingestion of inappropriate foods and chemicals irritation create a state of chronic inflammation. Our immune system can become fatigued, working at a low level, no longer able to generate enough energy for full protection, but still causing on going cell damage through low-grade inflammation. We become both depleted of certain white blood cells and others continue to maintain the inflammation.

The following are the most common symptoms of bone marrow fatigue. However, each person may experience symptoms differently. Symptoms may include:

LOW PLATELETS:

  • Easy bruising
  • Bleeding: nose bleeds, gums, or mouth
  • Tiny red spots on the skin (petechiae)
  • Blood in the urine
  • Dark or black bowel movements

LOW WHITE BLOOD CELLS:

  • Fever and chills
  • Rash
  • Diarrhea
  • Signs of infection (anywhere in the body):
  • Swelling
  • Redness
  • An area that is warm to touch

LOW RED BLOOD CELLS:

  • Fatigue
  • Paleness of skin, lips, and nail beds
  • Increased heart rate
  • Tires easily with exertion
  • Dizziness
  • Shortness of breath

Myelodysplastic Syndrome (MDS)

The myelodysplastic syndromes (MDS) are all disorders of the stem cell in the bone marrow responsible for producing blood cells. In MDS, blood production of Red and White Blood Cells is disorderly and ineffective. The number and quality of blood-forming cells decline, sometimes irreversibly, further impairing blood cell production.

What are the symptoms of Bone Marrow Fatigue and MDS?

Symptoms vary depending on the individual and the severity and time the bone marrow has been overworked. Symptoms may include:

  • Tiredness, or fatigue
  • Weakness
  • Excessive bleeding
  • Pinpoint red spots on the skin caused by bleeding from small blood vessels
  • Easy bruising
  • Frequent infections
  • Fevers
  • Pale skin
  • Shortness of breath

Compare these symptoms to your diagnosis of choice – Thyroid, Fibromyalgia, Lyme, etc. All of these symptoms would be diagnostic of those conditions without question.

Lower risk myelodysplastic syndromes (MDSs) are characterized by increased apoptosis of hematopoietic cells in the bone marrow (BM). The mechanism driving this excessive apoptosis involves multiple immune molecules, including inflammatory cytokines such as interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α) and interleukins (ILs). Interleukin-17 (IL-17) is the hallmark cytokine produced by CD4(+) Th17 cells, and IL-17 mediates activation of the adaptive T-cell response inducing an inflammatory cytokine environment. Elevated IL-17 levels and IL-17-induced IFN-γ and TNF-α overproduction may be involved in the pathogenesis of lower risk MDS. Bone broth stimulates production of IL-17.

Opposing memes of Medical vs. Alternative / Functional Practitioners.

The Medical Communitysuppresses the immune system with stronger and stronger drugs, i.e. LDN, hydrocortisone, etc.

Alternative and Functional Practitionersbelieve the autoimmune reaction occurs because the tissue is so toxic that the immune system basically can’t tell the good guys from the bad guys. It then starts attacking the tissues where the toxins are pooled.

Both Communities believe the immune system is working perfectly except that it cannot tell healthy tissue from bad tissue; bad bugs from good bugs, etc.

The Alternative and Functional Practitionerstreat patients with immune stimulating supplements and say, “You are going through a ‘Herx’ or ‘Flair.’ You will have more and more good days, less bad days. Stick with it.” “The flare-ups won’t be as bad or last as long.” This all makes perfect sense when they say it. Plus numerous websites say the same thing, so it must be true. They treat going through a ‘Herx’ or a ‘Flair’ as a rite of passage. I did this myself.  They claim – Don’t be afraid to stimulate the lymph, stimulate the immune system. It is the only way to heal these diseases.

Both of these memes will see initial success. After a three months the immune system will break free of the suppression or become so fatigued from the constant stimulation it will not be able to respond. Exaggerated response occur with administering more drugs or explained away as a ‘Herx’ or ‘Flair.’

Overstimulation of the Immune System

It is possibly to have an over active immune system, in very simple terms that is what is happening when you have an autoimmune disease. Autoimmunity is an ‘out of control’immune response. Honestly the entire idea of “boosting the immune system” is an invention of the supplement industry designed to sell products that practitioners capitalize on. It is validated by the ‘Common Cold.” Boost the immune system and it lasts seven days. Without immune stimulators it last a week. Okay the symptoms are less using immune stimulants. I’ve done that myself. It’s a great scam because both sick and healthy people think they need it.

This has then been extrapolated to any disease. Boosting the immune system will heal any disease in theory. They blindly follow this meme of immune stimulation. When in reality, more harm than good is being done. Everything is based on symptoms. Eventually with constant immune stimulation using supplements, bone broth, etc. The bone marrow producing the immune cells becomes so fatigued that quality and quantity of blood cells is impaired. The character of the immune cells behavior is changed. They want the immune system always on the hunt, always looking for something to do. Antibodies from previous exposure are deemed current infection. Why don’t the antibodies go away? They are memory cells from previous exposure not from an active infection.

Bone Marrow Fatigue is characterized by increased damage and/or death of hematopoietic cells in the bone marrow (BM). Here is where the miracle of immune-stimulation occurs. Inflammation is caused by an immune response. Without immune cells, inflammation is reduced. Based on reduced symptomatology or the lack thereof, this is a success until it is not. They crash the immune system by overstimulation, claiming success even though the patient has not improved overall.

Elegance in Healing

It was during the time when I was one of five Doctors across the United States given carte’ blanc immune lab testing that I realized the ‘Herx’ and/or ‘Flair’ is a Cytokine Storm with Th17 leading the charge. The cytokine storm have captured little attention of the public and the healthcare community alike, and while the general notion of an excessive or uncontrolled release of proinflammatory cytokines is well known in research, the concept of a cytokine storm and the biological consequences of cytokine overproduction are not clearly defined or recognized. Read More…

When the immune system is fighting pathogens, cytokines signal immune cells such as T-cells and macrophages to travel to the site of infection. In addition, cytokines activate those cells, stimulating them to produce more cytokines. Normally, this feedback loop is kept in check by the body. However, in some instances, the reaction becomes uncontrolled, and too many immune cells are activated in a single place. Bone Broth is loaded with cytokines signalling the immune system to respond in the overproduction of immune cells and attracting the immune cells to the location of the bone broth. Thus, promoting gut inflammation. Someone that is immune suppressed will feel better, temporarily. Then the blame is shifted to food sensitivities because ‘bone broth’ is healthy and could not possibly do any harm.

The cytokine storm is caused by an exaggerated response when the immune system encounters a new and highly pathogenic invader or a ‘false flag’ by immune stimulating foods and supplements. Cytokine storms have potential to do significant damage to body tissues and organs.

Healing must be elegant, working with the body’s own natural healing momentum and capabilities.

Cytokine Storm Treatment

The clinical presentations of all cytokine storm symptoms (CSS) can be strikingly similar, creating diagnostic uncertainty. However, clinicians should avoid the temptation to treat all CSS equally, because the triggers inciting inflammatory responses vary widely. It it thought that failure to identify and address this underlying trigger(s) results in delayed, nonoptimal, or potentially harmful consequences. However, chasing triggers is futile until the immune system is calmed and quieted. More often than not, calming and quieting the immune system eliminates the majority of the so called triggers.

You are a unique individual with your own set of circumstances. Stop trying to find a diagnosis box to stuff yourself into. You need help and I can provide assistance in sorting your system out. Call today 530-615-4083.