What are the Effect of Dietary Lectins on Thyroid TSH Receptors

Lectins can attach themselves to Thyroid Stimulating Hormone (TSH) receptor sites and play havoc in two ways. The first is that the Lectins are able to “fit” the receptor sufficiently enough to stimulate the thyroid but the effects are different in those with hyperthyroid or Autoimmune Hyperthyroid and low thyroid or Hashimoto thyroiditis. The second effect is that the immune response to the lectin stimulation starts an autoimmune response to the thyroid stimulating hormone (TSH) receptorson the thyroid.

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This 38 year old woman experience significant changes in her health by going on a Lectin Free Diet. The diet didn't stop the Cytokine Storms but significantly reduced their frequency.
I am 38 years old and throughout my life I have been to countless numbers of doctors dealing with digestion issues, parasites, migraines, allergies, blood sugar sensitivities, lack of energy, etc… By January 2013, my health had severely taken its toll, doctors given no explanation and I was barely able to walk by this point.  From what I believe is an absolute miracle, I came across an article from Wellness Alternatives.  I cannot thank you and your staff enough for saving my life and for getting my health back onto the road of recovery.  It has truly been a blessing to having met you.  I am absolutely amazed that through the blood work and quick turnaround analysis you were able to target the problem that I have had for years. Your knowledge,  professionalism and support throughout the past few months that I have met you has been truly inspirational.  I really am most grateful for what you have done for me and our family.
Sincerely, R. K.
Using the results from the Neuroscience Stimulated Cytokine Panel and NeuroEndocrine Comprehensive Panel, a protocol specifically designed for her has further reduced the occurrence of  the Cytokine Storms.

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Are Edible Enemies contributing to poor health and inflammation? Lectins cause a plethora of damage to the body, promoting chronic inflammation and sensitivity. Take the Edible Enemy Quiz to test your knowledge on lectins.

Use the Lectin Control Formula to reduce the inflammatory response that occurs due to lectin consumption. Take two capsules with each meal.

Use Registration Code: DP283 to get access to the Doctor's Supplements Store.
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What Are Lectin?

The production of lectins, alkaloids and secondary metabolites are a defense mechanism to protect themselves and their seeds from consumption while the plant is growing and before the seeds are ready for dispersal. For the purposes of this blog the listed secondary metabolites listed below will be referred to as Lectins unless specifically mentioned. Lectins occur naturally in organic and conventionally grown vegetables and fruit. Lectins occur artificially in Genetically Modified and Selectively Bred - organically or conventionally grown vegetables and fruits.

Plants are naturally genetically modified to survive in the primal environment of nature and are artificially genetically modified to survive their trip to the grocery store.

Plant Lectin Regulation of Vegetable & Fruit Consumption

Plants invest energy into the production of seeds. Plants have evolved to encourage vegetable and fruit seed dispersal but also evolved mechanisms to decrease consumption of vegetables and fruits when unripe and from non-seed dispersing predators. To this end, plants have developed physical and chemical deterrents.

Physical deterrents:

  • Cryptic coloration (e.g. green fruits blend in with the plant leaves)
  • Unpalatable textures (e.g. thick skins made of anti-nutritive substances)
  • Resins and saps (e.g. prevent animals from swallowing)
  • Repellent substances, hard outer coats, spines, thorns.

Chemical deterrents 

When immature or out-of-season, the seed, grain, vegetable or fruit are protected by chemical deterrents such as lectins to keep themselves from being eaten to extinction. Chemical deterrents in plants are called secondary metabolites, i.e.trypsin inhibitor, chymotrypsin inhibitor, α-amylase inhibitor, phytohemagluttinin (lectin), phytic acid, oxalic acid, nitrate and nitrite, L-mimosine, canavanine, L-DOPA, glucosinolates, cyanogenic glucosides/cyanogens, tannins, gossypol, chlorogenic acid, saponins, phorbol esters and alkaloids. 

Damage Caused By Lectins:

  • They bind to the thyroid TSH-receptorsacting as long-acting thyroid stimulator (LATS)stimulating the activation of TSH-receptor antibodies.
  • Lectins acting as LATS stimulate overproductionof thyroid hormones in those suffering from Hyperthyroid or Graves disease.
  • Lectins acting as LATS block productionof thyroid hormones in those suffering from low thyroid or Hashimoto’s thyroiditis.
  • Lectins are toxic to wounded cells and inhibit the natural repair system of the GI tract.
  • Lectins are known to “unlock” (breakthrough) the barrier variables of the GI lining and allow large undigested protein molecules into the bloodstream.
  • Lectins serve as a "Trojan horse" allowing intact or nearly intact foreign proteins to invade our barrier variables (natural gut defenses) and enter behind the lines causing damage well beyond the gut and into the joints, brain and skin of affected individuals provoking cytokine immune responses.
  • They can bind to red blood cells causing the cells to clump together resulting in a form of anemia.
  • They can damage collagen and connective tissues in joints.
  • They are directly related to Rheumatoid Arthritis.
  • They can bind to the stomach lining even when the pH is 3 or less.
  • They stimulate abnormal thickening of the pancreas interfering with exocrine cells production of enzymes and endocrine cells production of insulin.
  • They stimulate abnormal thickening of the lining of the gut.
  • They damage the villi lining the gut.
  • They stimulate the shift the microbial ecology promoting the overgrowth of E. coli.
  • The abnormal thickening of the pancreas and gut lining plus the microbial shift exacts a nutritional penalty on the absorption of nutrition.
  • They can provoke IgG and IgM antibodies causing Type 2 Hypersensitivity immune responses.
  • They provoke a direct cytokine driven immune response causing cytokine storms, invisible illness symptoms and cytokine-induced sickness behavior.

Effects of Dietary Lectins on the Thyroid

Lectins can attach themselves to a thyroid receptor site and play havoc in two ways. The first is that the Lectins are able to "fit" the receptor sufficiently enough to stimulate the thyroid but not enough fit sufficiently to produce thyroid hormones. The second effect is that the immune response to the lectin stimulation starts an autoimmune response to the thyroid.

Concerned about your Thyroid?

Thyroid stimulating hormone (TSH) at various concentrations significantly increased the response of lymphocytes to both lectins found in legumes and in other vegetables and fruit. Lectins may cause the activation of ‘long-acting thyroid stimulator (LATS)’also known as thyroid stimulating immunoglobulins, or TSI, in the blood.  TSI or LATS are antibodies that bind to special receptors on the thyroid gland than normally bind to thyroid stimulating hormone (TSH). TSH is the hormone that stimulates the thyroid gland to secrete thyroid hormones.  TSIs mimic the effect of TSH, thereby causing the thyroid to secrete excessthyroid hormone. LATS mimic the effect of TSH only stimulating the thyroid but not producing any thyroid hormones.

Lectins act as Long-Acting Thyroid Stimulators (LATS) and cause the activation of Thyroid Stimulating Hormone Receptor Antibodies (TSH-R Ab). These LATS appear to act similarly to TSH after attaching to the TSH receptor. The LATS are able to "fit" the receptor sufficiently well to stimulate the thyroid while blocking the production of thyroid hormones. This activates the immune system to produce TSH-R Ab to the thyroid stimulating hormone receptors. TSH-R Ab Autoantibodies act as thyroid stimulator agonist in autoimmune hyperthyroid (Graves disease) mimicking the effects of TSH and causes the overproduction of thyroid hormones with hyperthyroid symptoms. TSH-R Ab act as TSH antagonist in autoimmune hypothyroidism (Hashimoto thyroiditis) causing an inverse reaction blocking the production of thyroid hormones making it seem as if the individual is suffering from a low thyroid.

For those with low thyroid, their TSH levels will be low but the thyroid is being stimulated resulting in swelling, tenderness and irritation to the thyroid. Those who have Hashimoto’s, hyperthyroid or Grave’s disease the TSH-R antibody will stimulate the production of TPO antibodies resulting in an immune attack on the thyroid causing further destruction. This is often the case for those with elevated TPO antibodies who are doing all the right things but still have high TPO Ab.

Lectin excited T cells, which produce immunoglobulin excited thyroid function, causing hyperthyroidism. Although pituitary TSH release is suppressed, thyroid-stimulating antibodies not subject to negative feedback maintain the hyperthyroidism. These antibodies appear to act similarly to TSH and via the TSH receptor.

Lectin Exposure  Symptoms

Symptoms could be obvious, such as gas, bloating, diarrhea, or constipation (or both, alternating). Less obvious food related symptoms may include headache, fatigue, 'indigestion,’ skin problems including hives, psoriasis, acne, swollen joints, or water retention. While some symptoms will resolve quickly after eliminating an offending family, other symptoms may take 6-12 months. Be patient. If you are genetically intolerant, you will never be able to consume that group of foods safely.

Some symptoms may occur chronically and may seem unrelated to a gut/food or lectin intolerance reactions. This group of symptoms includes the so-called degenerative diseases and autoimmune diseases like those mentioned in the list at the beginning of this report including ‘Invisible Illness,’ Cytokine-Induced Sickness Behavior, atherosclerosis, hypertension, osteoporosis, senile dementia, osteoarthritis and Rheumatoid Arthritis, inflammatory joint diseases, fibromyalgia, chronic fatigue, and adult onset diabetes. Obesity has been associated with consumption of 'edible enemy' lectins.

Are Edible Enemies contributing to poor health and inflammation? Lectins cause a plethora of damage to the body, promoting chronic inflammation and sensitivity. Take the Edible Enemy Quiz to test your knowledge on lectins.

Use the Lectin Control Formula to reduce the inflammatory response that occurs due to lectin consumption. Take two capsules with each meal.

I want the Lectin eBookAutoimmune Diet Lectin Avoidance Guidelines
Use Registration Code: DP283 to get access to the Doctor's Supplements Store.

Lectin Toxicity Evades Antibody-Based Blood Tests

The type of harm lectins do is harder to diagnose than in classically defined food allergies or sensitivities. In other words, confirmation of intolerance will not be found in IgA, IgG, IgE antibody, allergy or intestinal biopsy testing because the damage done is a direct cytokine driven response, and not necessarily immune-medicated or only secondarily so. Intestinal biopsy testing may be suspect because lectins cause a thickening of the intestinal lining. The medical community is looking for thinning and damage to the intestinal lining.

The diagnostic “invisibility” is why lectin consumption is rarely linked to the ailments that afflict those who consume them. While lectins are not the sole or primary cause of a wide range of disorders, them are a major factor in sustaining or reinforcing injuries or diseases once they are initiated and/or established in the body. This response will deplete your anti-inflammatory cytokines and inhibitory neurotransmitters. Many will suffer cytokine storms during flair-ups. Some will develop into an invisible illness known as Cytokine-Induce Sickness Behavior.

Once lectins make it through a compromised mucosa and/or digestive lining. It can exert systemic effects which can easily become overlooked as being caused by eating legumes, fruits or vegetables. The best tests to determine how lectins are affecting your cytokine immune status and neurotransmitter levels are the:

  • Neuroscience Stimulated Cytokine Analysis Comprehensive
  • Neuroscience NeuroEndocrine Comprehensive
Base: General Overall Immune Response
PHA (Lectin): Immune Response when exposed to Lectins
LPS (Bacteria): Immune Response when exposed to Bacteria
Blue: Immune Suppressed or Immunocompromised
Red: Immune Activated or Stimulation

Four Different Hashimoto Patients - Four Different Immune Responses

All had bad reactions with the Th1/TH2 challenge. Why? All suffered a lectin driven immune response. All have an overactive Th17 immune response. Three have a suppressed TH1 response. One has a suppressed TH2 response. The upper right is immunocompromised. The lower right is immune stimulated to everything. The lower left is a raw vegan over-consuming Soft and Hard Lectins. The upper left TH1 immune system collapses when exposed to bacteria driving straight into TH17.

Systemic Effect of Lectins 

Lectins may influence absorption, metabolism and systemic availability of nutrition by two different but possibly simultaneous mechanisms.

Lectins can indirectly influence hormones (the endocrine system of the body) by binding to the neuroendocrine cells of the gut and as a consequence of this input, release message molecules (hormones) to the blood. Alternatively, lectins can pass through the gut wall into the blood circulation and thus may directly influence peripheral tissues and body metabolism by mimicking the effects of endocrine hormones. The organs most often affected are the pancreas, skeletal muscle, liver, kidneys and thymus.

Thymus, spleen and other organs: Overconsumption of Soft Lectins causes the thymus and spleen to begin decreasing in size wasting away. Some of these are irreversible with potentially serious consequences for the immune system, especially T cell-mediated immunity.

Effects of Dietary Lectins on Inflammatory Cytokines

Cytokines are several different types of substances that are produced by cells within the immune system. These substances relay signals between the immune system cells. By relaying messages between the cells, these cytokines help to trigger the immune system’s response to whatever threat is present.

Lectins strikingly increase levels of multiple pro-inflammatory cytokines (especially interleukin 2 receptor (IL-2), tumor necrosis factor alpha (TNF-α), IL-6, IL-8).

Cytokines, (mediators of acute inflammation) are generated to induce cell breakdown and death. Cytokines can produce an inflammatory response to food independent of the allergic reaction that most are familiar with.  Food allergy or cross-reactive testing will not detect a cytokine induced inflammatory response to food. This requires specialized testing done with the NEI Stimulated Cytokine panel that measures these cytokine and chemokines.

A phenomenon involving the function of inflammatory cytokines is known as a cytokine storm. Essentially, this is a situation where the balance of communication between immune cells and the cytokines present is interrupted.

When the inflammatory cytokines are involved in some sort of storm situation, there is a loopback created between both types of cytokines and the immune cells. The pro-inflammatory cytokines go wild – like college students on Spring Break. There are several common signs that indicate that a storm is present, including fever, body aches and nausea, along with stronger symptoms that are related directly to the ailment itself. Similar to how the college student feels after a week long binge that does not wear off.

Immune Supportive Supplements

A person is said to be immunocompromised when their immune system is incapable of working at full capacity. The immune system is how the body fights off diseases and protects itself against new infections, so someone who is immunocompromised will usually get sick more often, stay sick longer, and be more vulnerable to different types of infections. They may be more inclined to use supplements to stimulate the immune system. Until they become immune suppressed. Then they rarely get “sick.” Immunosuppressed individuals never feel well and start developing symptoms associated with Cytokine Induced Sickness Behavior (CISB).

Information from secondary sources suggests that supplementing with immune stimulating supplements, i.e. thymus gland extracts, have been shown to enhance responsiveness to Lectins and have been able to produce an cytokine storm in immunocompromised patients.

Lectins: Edible Enemies

Being realistic regarding diet is that there is always a sliding scale of lesser evils that we exchange for the experience of enjoying our foods and obtaining the comfort they provide. Because some food toxins cannot be removed from foods and other may be created during processing or cooking, consumption of small quantities of food toxins is unavoidable.

How problematic or reactive lectins are for you depends upon the health of your gastrointestinal lining, the behavior of your microflora and your immune status. If you have a Ghetto Gutwhere the gut lining is impaired, the microbes are misbehaving, and your ability to produce digestive chemistry is less than optimal. Any food you commonly eat will provoke a reaction including organic foods. This combination of factors will change your immune status depleting the inhibitory neurotransmitters and anti-inflammatory cytokines necessary to control the Neuro-Endo-Immune Super-system. When it comes to the immune response, small insignificant changes in lectin exposure can mean the difference between being reactive or not.

The Autoimmune Diet Lectin Avoidance Guidelines will reduce your exposure to lectins, GMOs. The Seasonal - Four Day Rotation diet will add variety to your diet while reducing your risk of creating food sensitivities.

Your chances of eating your way out of this will be significantly increased by following these guidelines. You will still need help re-regulating your neurotransmitters, cytokines and restoring the sequencing of your digestive tract.

Are Edible Enemies contributing to poor health and inflammation? Lectins cause a plethora of damage to the body, promoting chronic inflammation and sensitivity. Take the Edible Enemy Quiz to test your knowledge on lectins.

Use the Lectin Control Formula to reduce the inflammatory response that occurs due to lectin consumption. Take two capsules with each meal.

I want the Lectin eBookAutoimmune Diet Lectin Avoidance Guidelines
Use Registration Code: DP283 to get access to the Doctor's Supplements Store.

Iodine and the Thyroid: Part 2 Iodine vs. Antibody Testing

In the post: Iodine and the Thyroid: Part 1, I stated that the proponents of iodine will quote studies supporting iodine use but start stammering and yammering like they have a swollen tongue (probably due to their iodine deficiency) when asked about the studies reporting autoimmune thyroid caused by iodine.

This post attracted responses by iodine proponents validating the point of my blog. Iodine proponents never mention any link between iodine and autoimmune thyroid or do any lab testing looking for autoimmune thyroid induced by iodine supplementation.

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Ironically the source of this response, a Laboratory Associate from a well-known lab could not have known that a patient brought in Iodine level reports from this lab last week. The lab results provided by this lab are good. I use them every time a patient brings them but I will not use their treatment recommendations for reasons you will see below.

“Hello Dr Peterson, 

I just finished reading your blog post about iodine and I have a couple of questions. 

First, my iodine related background. 

  • Developed an iodine test in dried urine that is now in production and used to detect dietary iodine deficiency.
  • Read through over 600 complete publications on iodine, the thyroid, and halides
  • Aware of both sides of the iodine supplementation argument (high and low dose)
  • Constantly following iodine blogs, forums, twitter etc.
  • Talked with many doctors, over the phone and at conferences, about their experience with iodine supplementation
  • Recently published a paper on Japanese iodine intake and the health of the Japanese people 
  • Completed a study on the iodine-loading test to determine why so many individuals fail and how a 50mg dose is excreted
  • Investigated whether iodine or other halides cause the side effects seen in those who take large amounts of iodine 

As I read through your blog post, I picked up that you were against high dosing of iodine, yet you mention supplementing with proper amounts when needed. 

For both an “iodine sufficient” (in this case, at least 150ug/day) and an “iodine deficient” individual, what dosing do you recommend? Do you see any benefits from supplementation with iodine or iodide outside of thyroid hormone production?”

I have to admit in Iodine and the Thyroid, I omitted their fall back excuse for recommending iodine – “Ya-but Japanese people eat kelp and kelp has iodine.” As you can read in the proponents email, there is no mention of autoimmunity. But admits to being aware of both sides of iodine supplementation – “high and low dose”. I didn’t see any mention of iodine dosage causing autoimmune thyroid. How do you read “over 600” complete publications and not find any mention of autoimmunity?

I will use the recommendations from this particular lab to answer this question. As you can see below, starting in July 2011 this patient was taking 50 mg of oral iodine/iodide for her “iodine deficiency”. She felt better for the first 30 days but soon after that began experiencing a severe decline in her health. Clumps of hair were falling out; fatigue, depression and when she reported this to her doctor ordered an iodine test. Her levels of iodine were 61,132. The normal range for iodine is 100-1,100 with the optimal being 150-300. If my math is correct that is 203 times the optimal level. When she questioned her iodine levels the doctor refused to take her call.

In addition to the iodine test, a blood test was done which included thyroid antibodies using the AtheNA methodology with ranges different from the microsomal antibody test. The older microsomal antibody test ranges for thyroid peroxidase antibodies are 0 – 34. The AtheNA ranges are a new methodology for measuring Thyroid Antibodies. These include thyroglobulin antibody and thyroid peroxidase antibody, which is a more specific test measuring the active antigen in the older microsomal antibody test.

As you can see this patient with 203 times the recommended levels using the “low dose” iodine supplementation has Thyroglobulin antibody levels of 192. This would be considered positive for Autoimmune Hashimoto’s thyroiditis, based on the strongly positive Thyroglobulin antibodies. This lab assistant and doctor fell into the Green Allopathy mind trap of “If I recommend it – it can do no harm.”

Thyroglobulin and thyroid peroxidase antibodies are most typically associated with Hashimoto’s thyroiditis or Graves’ disease, but can also be found in myxedema, granulomatous thyroiditis, nontoxic nodular goiter, thyroid carcinoma, and rarely in some other conditions.

Since her doctor wouldn’t answer her questions she sought out a different opinion and found my office. Unfortunately this is not an isolated incident. Women and men come into my office with similar stories every week. They feel better initially and then fall apart. Some continue taking iodine because their doctor says it is good for them. While others stop it as this woman did when she could not get the answers she sought.

She started feeling better stopping the iodine but after an autoimmune response is stimulated it can continue for six months or more. The autoimmune attack doesn’t stop but continues with the signs and symptoms less noticeable. Damage to your body is still occurring.

After triaging her case, a protocol was designed to re-regulate her immune system to reduce the autoimmune attack on her body and support restoration of the metabolic processes contributing to her condition.

Autoimmune disease is a serious health condition that should not be taken lightly. I don’t remember being told of the link between iodine and autoimmune thyroid while in school. But once I was told of the link I immediately stopped recommending iodine inappropriately. If your healthcare provider isn’t aware of the connection, you should inform them. If they ignore the connection you have to ask yourself what you want to do. Are you willing to risk your health because they dismiss the connection between iodine supplements and autoimmune thyroid?

If you decide to continue taking iodine, I wish you the best. For those that want to take iodine and work with our office, you will be dismissed as our patient. If you are confused in need of help, we can help answer your questions and develop a program to get you feeling better.

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Iodine toxicity questions- Call today! 530-615-4083

Iodine for the Thyroid?

The debate regarding iodine and the thyroid is more polarized than that of democrats and republicans within the healthcare community. With each side is very adept at supporting their view with numerous studies, it becomes very confusing as to whether iodine is good or bad. Sometimes during the debate they claim expertise. It is interesting to compare their knowledge to reality. To see what happens when their recommendations are compared to lab testing. Iodine and the Thyroid: Part 2 Iodine vs. Antibody Testing

My decision is based on two events that occurred in my life. While attending chiropractic college, we were told iodine was necessary for proper thyroid function, therefore use iodine for hypothyroid. As a result of this I recommended the iodine patch test to treat thyroid patients. One woman I made this recommendation to seemed to respond well intitially. I say initially because she returned six months later looking in horrible shape. Eyes protruding, almost bald, 30 pounds heavier complaining of constant fatigue. What happened? I noticed a brown spot on her arm and thought it was an old bruise. She replied, she had just applied her iodine and it had not absorbed in yet. When asked why she had continued the iodine, she said she felt so good on it in the beginning, she decided to stay on it. She had been on the web and self-diagnosed herself with Candida attributing that to her current state of health. I decided then and there to never recommend iodine again until I understood what had happened.

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The second incident involved my own health. At the same time I recommended her use of iodine, I was using progesterone. Why, because a well known book recommended progesterone for men. Shortly after this I attended Dr. Kharrazian’s Functional Endocrinology course. Imagine my horror as he described what happens to those using progesterone inappropriately, which coincidentaly was how I was feeling. In addition to this, he described what occurs with inappropriate use of iodine, with shouting erupting from three doctors saying they have used iodine for 30 years of collective practice and not once had there been any ill effects. After the shouting subsided, Dr. K calmly said he would not debate the issue in that venue and asked them to order TPO antibody tests on all of their patients using iodine. Then next year he would discuss iodine with them. The following year, the three were again sitting together and as Dr. K brought up the iodine topic I turned to view their response. All three were shaking their head in unison agreeing with Dr. K.

“No battle plan survives contact with the enemy”

All nutritional or hormonal theories are based upon optimal body function through the vitalistic view where the nutrient or hormones interact in a perfect environment. Treatment plans for iodine and hormones are made based upon optimal function in a perfect environment. Who among us has optimal body function in a perfect environment, with disease and inflammation as are our enemies?

When your plan meets your enemies in the real world, the real world wins. Nothing goes as planned. Errors pile up. Mistaken suppositions come back to bite you. The most brilliant plan loses touch with reality. However, the reliance on these treatment plans, especially with the incongruence between plan and reality is usually an exercise in self-delusion. When plans meet the real world, it’s not the real world that will yield to your plan. You must adapt whatever you’re doing to the circumstances truly at hand. This is where Functional Medicine shines.

Before the 1920s, iodine deficiency was common in the Great Lakes, Appalachian, and Northwestern U.S. regions and in most of Canada. Treatment of iodine deficiency by the introduction of iodized salt has eliminated the “goiter belt” in these areas. To this day, iodine deficiency is almost none existant with the introduction of iodized salt. But the notion of iodine deficiency carries on today.

Iodine you may know is one of the most important minerals for proper functioning of the thryoid. Iodine is an essential element that enables the thyroid gland to produce thyroid hormones. The plan is then extrapolated by iodine proponents into iodine makes the thyroid work better therefore use iodine supplementation. While in reality, iodine, which is high up on the atomic scale requires near perfect pH for its assimilation into the body. But, the thyroid doesn’t get access to iodine unless the body pH is near perfect in addition to many other factors.

Why Do People Feel Better on Iodine?

If you are hyperthyroid you will feel better through the Wolff-Chaikoff effect. The Wolff-Chaikoff1-8 effect is used to describe hypothyroidism caused by ingestion of a large amount of iodine. Hyperthyroidism is the term for overactive tissue within the thyroid gland causing an overproduction of thyroid hormones (thyroxine or “T4” and/or triiodothyronine or “T3”).

It is an autoregulatory phenomenon which inhibits formation of thyroid hormones inside of the thyroid follicle. This becomes evident secondary to elevated levels of circulating iodide. Wolff-Chaikoff effect lasts several days (around 10 days), after which it is followed by an “escape phenomenon”, which is described by resumption of normal organification of iodine and normal thyroid peroxidase function. High levels of intracellular iodide are known to suppress the transcription of thyroid peroxidase (TPO) enzyme, along with NADPH oxidase. The suppresion of the enzymes that attach iodide to thyroglobulin causes a reduction in the production of the downstream product, thyroxin (T4).

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Wolff-Chaikoff is observed in individuals without an obvious thyroid disorder, and especially in patients with autoimmune thyroiditis or those previously treated for thyroid diseases (Graves’ disease, subacute or pospartum thyroiditis, iatrogenic thyroid dysfunction.)

 The hypothyroidism is transient and thyroid function returns to normal in 2 to 3 weeks if  iodine usage is withdrawn, but transient T4 replacement therapy may be required in some patients. The patients who develop transient iodine-induced hypothyroidism must be followed long term thereafter because many will develop permanent primary hypothyroidism. Continued use of iodine supplementation will cause the Jod-Basedow phenomenon to occur.

If you are hypthyroid, iodine usage increases thyroid production of T4. The thyroid gland actively takes up iodine and incorporates iodine into thyroid hormone. This provokes the thyroid into hyperfunction with out any feedback control. Think of it like putting your car in cruise control and never touching the brakes. Long term use of iodine then drives a person into the Jod-Basedow phenomenon AKA Iodine-Induced Thyrotoxicosis.

Jod-Basedow9-19 phenomenon, a thyrotoxic condition caused by exposure to increased amounts of iodine, has historically been reported in regions deficient in iodine. However, when a person is given iodine supplements combined with dietary intake on a continual basis without monitoring, they develop a hyperfunction autoimmune response. It causes an increased activity of TPO antibodies that multiply dramatically with iodine supplements.

IODINE SKIN PATCH TEST

In addition to driving a person first into a Wolff-Chaikoff effect, then into a Jod-Basedow phenomenon and eventually into iodine-induced autoimmune disease. The iodine supplementation or the skin patch test will not in any way show a person what their TPO antibodies are and will be different for each person due to different rates of absorption and elimination.

IT IS TIME FOR A REALITY CHECK!

Knowing we don’t have an optimally functioning body in an imperfect environment, the rules for normal don’t apply. The urinary clearance tests are only as good as their liver is able to detoxify. This makes iodine clearance testing suspect.

The proponents of iodine will quote studies supporting iodine use but start stammering and yammering like they have a swollen tongue (probably due to their iodine deficiency) when asked about the studies reporting autoimmune thyroid caused by iodine. I have to question why iodine proponents discredit testing for thyroid antibodies. I think an autoimmune disease takes precedence over an alleged deficiency. To paraphrase the Lay’s Chip ad, “You can’t have just one autoimmunity.” Wouldn’t you want to know?

The other side is not anti-iodine but pro-proper use. There are cases where a person is found to be Primary Hypothyroid through lab testing, where limited supplementation of iodine is recommended. Hashimoto’s disease is the most common cause of hypothyroidism in the United States. Hashimoto’s disease is an autoimmune disorder in which your immune system inappropriately attacks your thyroid gland, causing damage to your thyroid cells and upsetting the balance of chemical reactions in your body. The inflammation caused by Hashimoto’s disease, also known as chronic lymphocytic thyroiditis, often leads to an underactive thyroid gland (hypothyroidism).

Most people who have Hashimoto’s thyroiditis never actually develop overactive thyroid symptoms. Over time they start to develop the symptoms of low thyroid function and have their TSH measured. Their TSH will usually be found to be high and they are typically diagnosed as primary hypothyroid and placed on thyroid hormone replacement.

The issue of their autoimmune attack is not addressed. Instead, the medical community considers your thyroid condition managed by having a normalized TSH from thyroid hormone replacement. While the alternative and iodine proponents consider it managed by iodine supplementation. At least the medical community is using lab testing.

You decide whether you want someone managing your health were everything is an iodine deficiency or someone who looks for the true underlying cause of your health condition.

Read More: Iodine and the Thyroid: Part 2 Iodine vs. Antibody Testing

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  2. Lesher JL Jr, Fitch MH, Dunlap DB., Subclinical hypothyroidism during potassium iodide therapy for lymphocutaneous sporotrichosis. Cutis. 1994 Mar;53(3):128-30.
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  7. Frey H. Hypofunction of the Thyroid Gland, due to Prolonged and  Excessive Intake of  Potassium Iodide. Acta Endocrinol (Copenh). 1964 Sep;47:105-20.
  8. Reinhardt W, Luster M, Rudorff KH, Heckmann C, Petrasch S, Lederbogen S, Haase R, Saller B, Reiners C, Reinwein D, Mann K.  Effect of small doses of iodine on thyroid function in patients with Hashimoto’s thyroiditis residing in an area of mild iodine deficiency. Eur J Endocrinol. 1998 Jul;139(1):23-8.
  9. El-Shirbiny AM, Stavrou SS, Dnistrian A, Sonenberg M, Larson SM, Divgi CR. Jod-Basedow syndrome following oral iodine and radioiodinated-antibody administration. J Nucl Med. 1997 Nov;38(11):1816-7. Erratum in: J Nucl Med 1998 Mar;39(3):489.
  10. Navarro FA. [Jod-Basedow phenomenon: who was Dr. Jod?] Rev Clin Esp. 1997 Jul;197(7):531. Spanish.
  11. Goday-Arnó A, García Rico A, Martínez-Riquelme A, Cano-Pérez JF. [Graves Basedow disease following treatment with magistral formulae for obesity. Jod-Basedow phenomenon?] Rev Clin Esp. 1996 Aug;196(8):536-8.
  12. Gómez de la Torre R, Enguix Armada A, García L, Otero J. [Thyroid nodule disease in a previously endemic goiter area] An Med Interna. 1993 Oct;10(10):487-9. Spanish.
  13. Yamada T. [Jod-Basedow (iodine-induced hyperthyroidism)] Ryoikibetsu Shokogun Shirizu. 1993;(1):367-9. Review. Japanese.
  14. Woeber KA. Iodine and thyroid disease. Med Clin North Am. 1991 Jan;75(1):169-78.
  15. Maberly GF, Corcoran JM, Eastman CJ. The effect of iodized oil on goitre size, thyroid function and the development of the Jod Basedow phenomenon. Clin Endocrinol (Oxf). 1982 Sep;17(3):253-9.
  16. Maberly GF, Eastman CJ, Corcoran JM. Effect of iodination of a village water-supply on goitre size and thyroid function. Lancet. 1981 Dec 5;2(8258):1270-2.
  17. Livadas DP, Koutras DA, Souvatzoglou A, Beckers C. The toxic effect of small iodine supplements in patients with autonomous thyroid nodules. Clin Endocrinol (Oxf). 1977 Aug;7(2):121-7.
  18. Birkhäuser M, Burer T, Busset R, Burger A. Diagnosis of hyperthyroidism when serum-thyroxine alone is raised. Lancet. 1977 Jul 9;2(8028):53-6.
  19. Spaulding SW, Burrow GN, Ramey JN, Donabedian RK. Effect of increased iodide intake on thyroid function in subjects on chronic lithium therapy. Acta Endocrinol (Copenh). 1977 Feb;84(2):290-6.

Autoimmune Diet Lectin Avoidance Guidelines

When immature or out-of-season, the seed, grain, vegetable or fruit are protected by chemical deterrents such as lectins to keep themselves from being eaten to extinction. Chemical deterrents in plants are called secondary metabolites, i.e.trypsin inhibitor, chymotrypsin inhibitor, α-amylase inhibitor, phytohemagluttinin (lectin), phytic acid, oxalic acid, nitrate and nitrite, L-mimosine, canavanine, L-DOPA, glucosinolates, cyanogenic glucosides/cyanogens, tannins, gossypol, chlorogenic acid, saponins, phorbol esters and alkaloids. The production of lectins, alkaloids and secondary metabolites are a defense mechanism to protect them from consumption while the plant is growing and before the seeds are ready for dispersal.

Are Edible Enemies contributing to poor health and inflammation? Lectins cause a plethora of damage to the body, promoting chronic inflammation and sensitivity. Take the Edible Enemy Quiz to test your knowledge on lectins.

Use the Lectin Control Formula to reduce the inflammatory response that occurs due to lectin consumption. Take two capsules with each meal.

Use Registration Code: DP283 to get access to the Doctor’s Supplements Store.

Get your “Autoimmune Diet Lectin Avoidance Guidelines” eBook

Click on this image to get your Autoimmune Diet Lectin Avoidance Guidelines eBook.

Lectins inhibit the natural repair system of the GI tract, potentially leaving the rest of the body open to the impact of errant, wandering (i.e. unwanted) material from the digestive system.  Perhaps the most insidious impacts lectins can leave in their wake is leaky gut. Leaky gut is a term used for the breach of the Barrier Variables of the intestinal lining produced by lectins moving hand in hand with other physical/environmental triggers and other anti-nutrients. Once the intestinal breach occurs, lectins and other particles (like partially digested food, toxins, etc.) can “leak” into the bloodstream and provoke an inflammatory cytokine response throughout the body. Lectins cause much more than Leaky Gut.

Damage Caused By Lectins:

  • Lectins are toxic to wounded cells and inhibit the natural repair system of the GI tract.
  • Lectins are known to “unlock” (breakthrough) the barrier variables of the GI lining and allow large undigested protein molecules into the bloodstream.
  • Lectins serve as a “Trojan horse” allowing intact or nearly intact foreign proteins to invade our barrier variables (natural gut defenses) and enter behind the lines causing damage well beyond the gut and into the joints, brain and skin of affected individuals provoking cytokine immune responses.
  • They can bind to red blood cells causing the cells to clump together resulting in a form of anemia.
  • They can damage collagen and connective tissues in joints.
  • They are directly related to Rheumatoid Arthritis.
  • They can bind to the stomach lining even when the pH is 3 or less.
  • They stimulate abnormal thickening of the pancreas interfering with exocrine cells production of enzymes and endocrine cells production of insulin.
  • They stimulate abnormal thickening of the lining of the gut.
  • They damage the villi lining the gut.
  • They stimulate the shift the microbial ecology promoting the overgrowth of E. coli.
  • The abnormal thickening of the pancreas and gut lining plus the microbial shift exacts a nutritional penalty on the absorption of nutrition.
  • They can provoke IgG and IgM antibodies causing Type 2 Hypersensitivity immune responses.
  • They bind to the thyroid TSH-receptors acting as long-acting thyroid stimulator (LATS) stimulating the activation of TSH-receptor antibodies.
  • They provoke a direct cytokine driven immune response causing cytokine storms, invisible illness symptoms and cytokine-induced sickness behavior.

The most common source of lectins is from plants.  They are present in seeds to protect the seeds from those who eats the plant or seed-containing fruit.  The second most common source of lectins is seafood.  Virtually all known plants contain lectins, usually as one of a number of proteins in seeds, but often also distributed amongst the other parts of plants including leaves, roots, tubers and bulbs.

Plants are naturally genetically modified to survive in the primal environment of nature and are artificially genetically modified to survive their trip to the grocery store.

Plant regulation of Fruit Consumption

Plants invest energy into the production of fruits. Plants have evolved to encourage fruit eaters to consume their fruit for seed dispersal but also evolved mechanisms to decrease consumption of fruits when unripe and from non-seed dispersing predators. Plants have physical and chemical adaptations.

Physical deterrents:

  • Cryptic coloration (e.g. green fruits blend in with the plant leaves)
  • Unpalatable textures (e.g. thick skins made of anti-nutritive substances)
  • Resins and saps (e.g. prevent animals from swallowing)
  • Repellent substances, hard outer coats, spines, thorns.

A seed is mostly food (starch, protein, fat) for the plant embryo that will grow from it.  This is also true of a chicken egg and just like the egg, the seed contains defensive proteins to inhibit the growth of bacteria, fungi and egg/seed eaters.  The egg has enzymes to degrade bacterial walls and proteins that bind iron, vitamins, etc. needed by bacteria and humans.  Eating many raw eggs can lead to vitamin deficiencies.  Boiling the eggs unravels the defensive proteins and makes them digestible and nutritious.

Plant lectins (phytohemagglutinins or hemagglutinins) have been shown to possess a remarkable array of biological activities.  Lectins ihibit the natural repair system of the GI tract, potentially leaving the rest of the body open to the impact of errant, wandering (i.e. unwanted) material from the digestive system. This is especially true when these lectins “unlock” barriers to entry and allow larger undigested protein molecules into the bloodstream.

Seeds block being digested by containing proteins that foul the digestion system of would be devourers.  Plants are naturally genetically modified to survive in the primal environment of nature and are artificially genetically modified to survive their trip to the grocery store.

Lectins Helps Seeds Survive Being Eaten

Seed dispersal is important for plants because it allows their progeny to move away from their parents in space and time. The advantages of seed dispersal may have led to the evolution of fleshy fruits, which entice animals to eat the fruits and move the plants seeds from place to place. While many fruit producing plant species would not disperse far without being consumed because they can usually germinate even if they fall to the ground directly below the parent plant.

In order for plants to protect themselves from natural predators, their seeds naturally contain a variety of very smart chemicals – lectins – which have the potential to disrupt the health of unsuspecting humans.  Lectins work at the cellular level by disrupting cellular metabolism.  Plant seeds are designed for survival in nature not a trip through the grocery store.  A single seed must have multiple lectins to survive being eaten and survive the trip from mouth to tail, i.e. chewing, digestive enzymes, gut bacteria and fermentation and finally transit through the colon.

Are Edible Enemies contributing to poor health and inflammation? Lectins cause a plethora of damage to the body, promoting chronic inflammation and sensitivity. Take the Edible Enemy Quiz to test your knowledge on lectins.

Use the Lectin Control Formula to reduce the inflammatory response that occurs due to lectin consumption. Take two capsules with each meal.

Use Registration Code: DP283 to get access to the Doctor’s Supplements Store.

Get your “Autoimmune Diet Lectin Avoidance Guidelines” eBook

Click on this image to get your Autoimmune Diet Lectin Avoidance Guidelines eBook.

This is done by a combination of a hard digestion-resistant hull and enzyme-resistant lectins covering the seed. Then after passing through the gut resist bacteria, fungi, insects, and worms surviving the heat generated during fermentation and the cold of winter or the heat of summer until it is time to germinate. Each requiring a different protective lectin.

Some seeds are activated by digestive enzymes, i.e. cedar tree berries, just as fire activates certain pine seeds. Lectin pine coneThese  pine trees, including Monterey Pine and Pond Pine,  are only able to reproduce if a fire destroys them. Their pine cones, which contain the seeds, are so tightly held in the cone. That the seed cannot be released to germinate unless a fire burns away the outer part of the cone. These are called “fire climax pines”. Seeds cannot germinate to form new trees until the parent trees have been destroyed in a forest fire, assuring that the new trees will not have to struggle in darkness among adult trees, but will only be among trees of the same age. When there is a fire, the number of seeds released is great enough to assure survival of enough new trees to reforest the area. Fire climax pines are able to maintain their presence against the incursion of other species of trees because fire destroys all of the adult trees, but only the pines are naturally replanted.

Wild bird are active consumers of all berries, fruits and nuts. Seeds falling directly under the plant or tree would have to compete with the parent tree for sunlight, water, and nutrition.

Seeds that fall to the ground, may find themselves lying under a pile – no pun intended – of their mother plants or other foliage as they wait for next spring to germinate. This leads to the growth of spoilage microbes, generating heat. Hot spots developing under the pile can be extremely hot (130-150oF). The more certain elements in the foliage a plant has at the end of the growing season, i.e. Legumes, beans, lentils, etc. The more likely this is to occur. The seeds must be able to survive heat for long periods of time. This makes them resistant to heat from cooking.

Growing up on the farm, I have seen fermenting forage spontaneously combust. In order to protect themselves from this danger, seeds have naturally developed a high tolerance to heat.  Making them resistant to the quick cooking methods used today providing high levels of hard lectins to those thinking they are eating a healthy diet.

Raw and relatively unprocessed foods are becoming more fashionable among health-conscious individuals in the Western world. Given the abundance of food in prosperous countries, such persons are therefore most likely exposed to greater doses of dietary lectins than at any time in human evolution. Ingesting lectins can cause flatulence. Consuming legumes and grains in their raw form can even result in nausea, diarrhea and vomiting. Lectins consumed raw or unprocessed are at their most toxic potential.

 

Grains

Grains, beans, nuts and seeds are all seeds. Rich in complex carbohydrates and fiber, they form the base of most healthy food pyramids. Grinding them whole is purported to make them healthier. When ground with the hulls removed makes them a dangerous refined flour to be avoided.

      • Grains, beans, nuts and seeds are all seeds.
      • Grains are the seeds of grasses, e.g. Wheat, corn, oats, and rice.
      • Grains are small, hard, dry seeds (with or without attached hulls or fruit layers).
      • Beans are the seeds of legumes, e.g. Peas, lentils, soybeans, and chickpeas.
      • Nuts are the seeds of trees, e.g. Walnuts, hazelnuts, almonds, cashews.
      • Seeds are the seeds of plants, e.g. Sesame seeds, poppy seeds and sunflower seeds.
Translation: Brown rice in high in fiber that prevents absorption of nutrients while resisting digestion and promoting damage from lectins. It is not what you eat but what you absorb that counts.

Lectins when consumed at low levels are slightly irritating, but when eaten in moderate quantities become more damaging.

What is the Neuro-Endo-Immune Supersystem?

The Neuro-Endo-Immune Supersystem communicates with the body via shared messenger molecules called neurotransmitters, cytokines or hormones. To help you understand the Neuro-Endo-Immune (NEI) Supersystem, allow me to use an analogy. The body is the computer hardware. Just as Microsoft Windows is the operating system for computers, the NEI Supersystem is the body’s operating system. I’ll use Windows rather than Mac because Windows and the NEI Supersystem are more susceptible to hackers (bacteria, parasites) and viruses.

Every computer must have an operating system to run other programs. Operating systems perform basic tasks, such as recognizing input from the keyboard, sending output to the screen, keeping track of files and directories on the hard drive, and controlling peripheral devices such as Bluetooth devices, printers, arms and legs. The operating system is the most important program that runs on a computer and in your body.

In your body, metabolic processes, digestion, reproduction and physical activity are examples of the programs. For large systems such as the human body, the operating system has even greater responsibilities and powers. It is like a traffic cop – it makes sure those different programs and users (organs) stay coordinated while at the same time do not interfere with each other.

Finding and fixing errors is an important job for the operating system. Repair programs rely on a simple and clean interface that doesn’t involve too much user interaction. In fact, the only thing you have to do is to allow the immune system to scan the hardware (body). The operating system is also responsible for security, ensuring that unauthorized users do not access the system.

Glitches and Hackers

Glitches are short-lived faults in a system. It frequently refers to an error which is not detected (no symptoms) at the time it occurs but shows up later as symptoms or disease conditions. Especially when the peripheral devices do not work as they were designed to.

The NEI Supersystem usually corrects occasional occurrences of these irritating disturbances. However, if these glitches occur frequently, the system fails to stay in sync and complete normal functions or to perform them properly. These glitches become a slippery slope as an effort is made to suppress the symptoms rather than identify the cause in the NEI Supersystem. A bug or hacker getting access into the operating system can also cause a glitch in the NEI Supersystem.

Computer hackers out for their own selfish interest break into the operating system, damaging the operating system. NEI Supersystem hackers (bacteria, yeast/mold and parasites) alter the NEI responses for their own selfish survival mechanisms.  Their preferred glitches are to create a favorable environment and make themselves invisible to the immune system for their survival.

After hackers break into your computer, the alterations to the operating system remain even though the hackers are long gone. It takes time for the security system to identify them after which it remembers their identity. Just as Windows sends out security updates, every time the immune cells are replaced they receive an updated list in the form of antibodies. Trying to eliminate the hackers after they are gone is futile. Stimulating the immune system in the absence of hackers only promotes the onset of autoimmunity.

Immature or out-of-season, the seed, grain, vegetable or fruit are protected by chemical deterrents known as Lectinsto keep themselves from being eaten to extinction. Lectins are most concentrated in the flesh of the fruit surrounding seeds. Due to the fact that seeds are the “babies” of the plants, necessary for the continuance of their species, protecting them is a priority.

Lectins bind to, interact and disrupt the basic components of NEI Supersystem causing glitches in the system. The flesh of immature or out-of-season fruit is toxic and yet considered a food. There are two principle means to increase the number of glitches in the NEI Supersystem by consuming: (1) Soft Lectins – an ordinarily non-toxic food which has become toxic through genetic modification and/or over-consumption of an ordinarily low-level toxicity food (2) Hard Lectins – Legumes, beans, lentils. Read More …

The Second Brain

The Second Brain or the “enteric nervous system” is located in the sheaths of tissue lining the esophagus, stomach, small intestine and colon. Considered a single entity, it is a network of neurons, neurotransmitters and proteins that zap messages between neurons, support cells like those found in the brain proper and a complex circuitry that enables it to act independently, learn, remember and, as the saying goes, produce gut feelings.

When nerves to the limbs are cut or damaged loosing communication with the brain and central nervous system, muscles are deprived of their direction and control becoming paralyzed. When the organs are deprived of communication with the brain and central nervous system, as in the case of paraplegics, quadriplegics or traumatic brain injury, they continue to function. In fact, the only function lost is the ability to decide when to #1 Pee and #2 Poo, which iscontrolled by the brain and central nervous system. In other words, if outside nerves are not required, then inside nerves must be the ones that do the job.

Components of the NEI Supersystem

Although the Neuro-Endo-Immune Supersystem has immune modulating capability, the relationships between the NEI components have, until recently, largely been separated into individual unrelated systems and the focus has been on low-hanging fruit, e.g. HPA axis.

Details of how the enteric nervous system mirrors the central nervous system have been emerging in recent years, according to Dr. Michael Gershon, professor of anatomy and cell biology at Columbia-Presbyterian Medical Center in New York. He is one of the founders of a new field of medicine called “neurogastroenterology.”

The gut contains 100 million neurons – more than the spinal cord. Major neurotransmitters like serotonin, dopamine, glutamate, norephinephrineand Gasotransmitterslike nitric oxide, carbon dioxide and hydrogen sulphideare in the gut.

The nervous, endocrine and immune systems communicate bidirectionally via shared messenger molecules variously called neurotransmitters, cytokines or hormones. Their classification as neurotransmitters, cytokines or hormones is more serendipity than a true reflection of their sphere of influence. Rather than these systems being discrete entities they constitute, in reality, a single higher-order entity as the Neuro-Endo-Immune Supersystem.

The cranial brain controls the muscular compartment of the body through the nervous system. Chewing stimulates the production of digestive chemistry prior to the arrival of food through the vagus nerve. Similar to switching the system on. Read More … From there, the abdominal organs are controlled primarily through hormones and neurotransmitters of the Abdominal brain. These are transported through the abdominal blood supply to support and control automatic processes in the body.

Neurotransmitters (Neuro)

Like Instant messaging (IM chat) used for text-based communication between two or more participants over the Internet or other types of networks within the body. IM–chat and nerves transmission happens in real-time.

Neurotransmitters are not unique to the brain and, in fact, act throughout the body and brain in varying capacities and concentrations. Many people aren’t aware, for instance that 95% of all serotonin production in the body occurs not in the brain, but in the gut! Within these very separate respective systems, the actions of neurotransmitters can vary hugely. Neurotransmitters stimulate opposite effects in the muscular and abdominal compartment. Those which stimulate and causes dilation of the blood vessels in one compartment – inhibits and constricts the blood vessels in the other. This is the basis of “Don’t go swimming after you have eaten.” For example, Serotonin enhances blood flow to the organs while Dopamine diminishes blood supply to the abdominal organs.

  • Paracrine neurotransmitters pass short distances to be used by local target tissue.
  • Autocrine neurotransmitters are produced and used in the same cell.
  • Certain bacteria have the capability to produce neurotransmitters. Usually as part of their survival strategy.

Brain/CNS Neurotransmitters

Movement of chemicals accomplishes communication of information between nerves across a small gap between nerve endings. These chemicals are called neurotransmitters. Neurotransmitters then cross the gap where they may be accepted by the next nerve at a specialized site called a receptor. Used primarily for control of the muscular areas of the body.

Brain/Central Nervous System Neurotransmitter Lab Testing Facts
  • Urinary neurotransmitter levels are NOTindicative of neurotransmitter levels in the central nervous system.
  • Urinary neurotransmitter testing can NOTbe used to test the levels of neurotransmitters present in the brain.
  • Urinary neurotransmitter testing can NOTbe used to determine neurotransmitter imbalances in the brain.
  • Urinary neurotransmitter test results can NOTbe explained in terms of brain and CNS function.
  • Brain-based neurologists do NOTrecognize the abdominal brain.
Abdominal/Enteric Neurotransmitter Lab Testing Facts
  • Splanchnologistsrecognize the abdominal and cranial brain. Unfortunately, splanchnologists are far and few between.
  • Urinary neurotransmitter CAN measure levels of neurotransmitters in the abdominal brain
  • Urinary neurotransmitter CAN provide information on organ function and dysfunction.
  • Urinary neurotransmitter CAN provide information on where the blood supply is being directed in the body.

Vasomotor control through Neurotransmitters

Neurotransmitters are used as IM chat communication by the abdominal nervous system. Neurotransmitters are primarily focused on controlling the blood supply in the body. Dr. DeJarnette, first published this information in 1931 ‘Vasomotor Control’. Unfortunately, the technology and scientific literature needed to validate it has only been available in the past ten years.

Vasomotor Nerves control the flow of blood throughout the body through neurotransmitters. Dr. DeJarnette wrote extensively on this in the 1930’s, twenty years before the discovery of serotonin (sero – blood; ton – tone; in – pertaining to). Did you think it was only involved in depression?

Immune control through Neurotransmitters

Neurotransmitters can stir up remarkably different opposing effects depending on concentration (presence of Vasomotor nerve fibers and extent of neurotransmitter release), receptor affinity, availability of neurotransmitters, and timing of autonomic activity in relation to the inflammatory responses.

Neurotransmitters are key players in the mystery-shrouded defense mechanism: how the abdominal nervous system body puts the brakes on an overenthusiastic inflammatory response. Inhibitory neurotransmitters may function as a paracrine or autocrine factors, exerting local control over the immune system.

Endocrine (Endo)

Endocrine glands are ductless. The endocrine system is a collection of glands that secrete hormones directly into the blood stream to be carried to a target organ or tissue. Hormone distribution in the body is subject to the control of the Vasomotor neurotransmitters. The hormones are delivered to the nearest capillaries, and spread throughout the body. The responses are delayed because hormones must first travel through the blood to reach the target organs.  The duration is longer because the kidneys filter the blood. Vasomotor control of the blood vessels can support or delay the delivery of hormones. The functions of the endocrine hormones are interrelated. Many of the hormones generated serve to alter the work of other endocrine hormones.

  • Hormones traveling long distance are endocrine.
    • Endocrine response is slower because hormones travel through the blood.
    • The duration in endocrine transmission is prolonged because kidneys have to filter the blood.
  • Paracrine hormones pass short distances to be used by local target tissue.
  • Autocrine hormones are produced and used in the same cell.

Here are a few of the areas governed by the endocrine system:

  • Reproduction
  • Responses to stress and injury
  • Growth and sexual development
  • Body energy levels
  • Internal balance of body systems
  • Bone and muscle strength
  • Immune stimulation and/or suppression

Endocrine hormonescan either stimulate or suppress the immune response. The effect of endocrine hormones on the immune system is the most over-looked aspect.

Exocrine

Exocrine glands differ from endocrine glands, because they have ducts that deliver the products in the superficial part of the body, such as the skin, or in the inner part where they are necessary, such as the pancreatic juice that is carried into the intestine to aid digestion. The glands that are found in the body are mostly exocrine glands.

  • Exocrine glands have ducts to carry hormones.
  • Exocrine hormones are released into the external environment, or outside of the body.
  • Endocrine hormones are released into the internal environment, or inside of the body.
  • Exocrine glands have sub-classifications.

Immune

Cytokinesare a class of proteins secreted in the immune system, used as messenger molecules to control the duration and strength of the immune response to foreign microorganisms. Many cytokines produced by T cells direct the immune response of various white blood cells (leukocytes) to a foreign microorganism in the body.

Chemokinesare cytokines that induce chemotaxis, which is the movement of a cell or group of cells that follow a chemical messenger to a new location. Unlike cytokines, chemokines have just one major role: to direct the chemotaxis of leukocytes toward foreign, potentially disease-causing microorganims so that these cells are labeled and destroyed by the immune response.

Chemokine and Cytokine Signaling

The first signal “When do I respond.”

Consists of the interaction of the immune cells and determines the specificity of the response.

The second signal “Will I respond?”

Provides the information that T cells need in order to respond to antigen. This signaling can be either positive (stimulation) or negative (inhibition). Hackers (bacteria, parasites and mold) survive by changing the signal or breaking the antibody.

The third signal:“How will I respond?”

Is delivered by the cytokines, chemokines or dendritic cells stimulating T cells to develop into TH1, TH2, TH17 or Treg T cells.

This fourth signal “What location do I respond to?”

Determines the Th1, Th2, Th17, Th2, Th23 response. Chemokines produce homing beacons that will direct them to migrate through tissues.

The fifth signal: “When do I stop responding?”

T cells (Tregs) were originally identified as having immunosuppressive functions through anti-inflammatory cytokines. This is not the only control over the immune response.

The sixth signal: “Did you say attack?”

Glitches (Lectins) and Hackers (bacteria, parasites and mold) disrupt and confuse multiple signals. This disruption can cause immune suppression to Hackers, while immune stimulation occurs to Glitches in the same TH-immune system (TH1, TH2, TH17 or Treg T). Read More…

Immunosuppression might not be the only function of T reg cells. They may convert into proinflammatory cells to promote immune responses.When the controls on the immune system have lost their ability to communicate, autoimmune disease is the consequence. The only tools the Medical community has is to induce immune suppression. In other words an ‘Iatrogenic Acquired Immune Deficiency.’ Read More …

On the other hand, the Alternative and Functional Medicine community focus on stimulating the immune system. They rely on the old adage, “Don’t worry, your body will know what to do.” The immune system does only what the signals tell it to do following the old adage as directed. Hackers disrupt the signals for their own survival. Think about the possibilities of stimulating the immune response with altered signals directing the response. To determine TH1 or TH2 dominance, a challenge is done. However the rules above still apply. There is no mention of TH17, which is the major system involved in autoimmunity. Read More …

For more information on the NEI Supersystem and which lab testing may best suited for your specific case. Contact Wellness Alternatives 530-615-4083

Are Edible Enemies contributing to poor health and inflammation? Lectins cause a plethora of damage to the body, promoting chronic inflammation and sensitivity. Take the Edible Enemy Quiz to test your knowledge on lectins.

Use the Lectin Control Formula to reduce the inflammatory response that occurs due to lectin consumption. Take two capsules with each meal.

Use Registration Code: DP283 to get access to the Doctor’s Supplements Store.

Get your “Autoimmune Diet Lectin Avoidance Guidelines” eBook

Click on this image to get your Autoimmune Diet Lectin Avoidance Guidelines eBook.

Is Low Dose Naltrexone (#ldn) Stimulating Autoimmunity?

Naltrexone (#ldn) is usually used in 50mg doses as a drug to help heroin or opium addicts, by blocking the effect of such drugs.  By blocking opioid receptors, naltrexone also blocks the reception of the opioid hormones (endorphins) that the brain and adrenal glands produce.   Many body tissues have receptors for the endorphins, including virtually every cell of the body’s immune system.

FDA-approved naltrexone, in a low dose (only 3mg), can boost the immune system, helping those with HIV/AIDS, cancer, and Autoimmune Diseases. The Immune System is “uncontrolled”in Autoimmune conditions. Boosting an uncontrolled Autoimmune response is a bad thing.

LDN is currently under experimental use for many conditions.  Preliminary results in theory are very encouraging: Naltrexone increases the body’s production of the beta and metenkephalin endorphins and blood tests have indicated that it can double or even triple the activity of natural killer cellsNaturalkillercells(also known as NK cells, K cells, and killercells) are a type of lymphocyte (a white blood cell) and a component of innate immune system. NK cellsplay a major role in the host-tissue rejection of both tumours and damaged cells.

Oh, but Doc, this is Low-Dose Naltrexone. My response: A single spark can ignite a forest fire.

A wealth of experimental data suggest that T cells are self-restricted or self-regulated. Immune regulators of the NEI Supersystem cannot be too high or too low as the self-regulation is dose-dependent. Artificially suppressing or stimulating the levels has detrimental effects on the immune response.

LDN works by suppressing the immune system. Eventually, to quote, Dr. Ian Malcolm of Jurassic Park:

… the kind of control you’re attempting simply is… it’s not possible. If there is one thing the history of evolution has taught us it’s that life (the immune system) will not be contained. Life (the immune system) breaks free, it expands to new territories and crashes through barriers, painfully, maybe even dangerously, but, uh… well, there it is.

There are three different methods by which the body fights infections.  While cellular immunity (Th1) directs Natural Killer T-cells and macrophages to attack abnormal cells and microorganisms at sites of infection inside the cells, humoral immunity (Th2) results in the production of antibodies used to neutralize foreign invaders and substances outside of the cells. T helper 17 cells (Th17) are a subset of T helper cells producing interleukin 17 (IL-17). They are developmentally distinct from Th1 and Th2 cells. Th17 cells are associated with autoimmune disease. The Th17 effector cells are triggered by IL-6 and TGF beta or IL-23 and IL-1β.

woman on fire
Are you on fire?

In many cases, all three arms of the immune system fight an infection.  At other times, only one is predominantly needed to control an infection.  A healthy immune system is both balanced and dynamic: it should be balanced between Th1 and Th2 and Th17 activity, switching back and forth between the three as needed.  This allows for a quick eradication of a threat and then a return to balance before responding to the next threat.  The inability to respond adequately with a Th1 response can result in chronic infection and cancer; an overactive Th2 response can contribute to allergies, various degenerative syndromes and autoimmune disease is a consequence of a Th17 response.  In autoimmune illnesses, all of the arms of the immune system are active, creating the inflammation and tissue injury in autoimmune disease.

A failure of the Th1 arm of the immune system and an overactive Th2 arm is implicated in a wide variety of chronic illnesses.  These include autoimmunity, CFS, candidiasis, multiple allergies, multiple chemical sensitivities (MCS), viral hepatitis, Hashimoto’s thyroiditis, cancer and other illnesses.  If these three arms of the immune system could be balanced by stimulating Th1 and decreasing Th2, then many of the symptoms associated with these chronic illnesses would diminish or disappear and we would have found the answer to immune restoration and balance or the equivalent of a cure. Unfortunately, where Th1 and Th2 leaves off, Th17 takes over and most treatments don’t take account of Th17. This is definitely the case for Low Dose Naltrexone (LDN).

While correct in theory, it is incorrect in terms of how the immune system functions. Most view the immune system only in terms of Th1, Th2 and rarely if ever include Th17. Cytokines, chemokines, neurotransmitters and hormones that control the Th1, Th2 and Th17 responses direct the immune response. Hormones are always thought of as only involved in sex and reproduction. However, progesterone, estriol and testosterone are immune suppressive. While two of the estrogens – estrone, and estradiol are immune stimulating. Not to mention the inflammatory hormone Etiocholanolone, which is rarely tested for and drives the Th17 response. Yes, Etiocholanolone is a hormone made from DHEA that drives Th17. All too often low DHEA is thought to be an adrenal problem, when it is actually being converted into etiocholanolone. Neurotransmitters work both to alert the immune system to an area of the body in distress and signal the immune system that the work is over. Again, rarely tested for. Collectively, this is known as the NEI Supersystem.

Th1 cells secrete INF-gamma and IL-2, which activate macrophages and cytotoxic T-cells to kill intracellular organisms; Type Th2 cells secrete IL-4, IL-5, and IL-10, which help B cells to secrete protective antibodies. Th17 cells are triggered by IL-6, IL-17, IL-1β, and IL-23 to clear out damaged tissue damaged by autoimmunity or the uterine lining during menstrual cycles or miscarriages.

Interferon gamma (IFNγ) is secreted by T helper cells (specifically, Th1 cells), cytotoxic T cells (TC cells), macrophages, mucosal epithelial cells and NK cells. Among the effects of increased IFNγ are:

  • Promotes NK cell activity
  • Increases antigen presentation and lysosome activity of macrophages.
  • Activates inducible nitric oxide synthase (iNOS)
  • Induces the production of IgG2a and IgG3 antibodies from activated plasma B cells
  • Causes normal cells to increase expression of class I MHC molecules as well as class II MHC on antigen-presenting cells.
  • Promotes adhesion and binding required for leukocyte migration
  • Induces the expression of intrinsic defense factors.
  • IFNγ is the primary cytokine that defines Th1 cells: Th1 cells secrete IFNγ, which in turn causes more undifferentiated CD4+ cells (Th0 cells) to differentiate into Th1 cells.

I recommend calming and quieting the immune system so it can respond appropriately when needed.

Low Dose Naltrexone works by stimulating suppression of the immune response. When immune suppression occurs, those using LDN don’t feel the pain and discomfort with their immune system being suppressed. It’s a win/winsituation. The patient isn’t feeling any pain and the Doctor isn’t getting asked by the patient isn’t feeling any better.

Low Dose Naltrexone works by Stimulating Suppression of the Immune system.

Parsing the Benefits of LDN

It’s worth mentioning LDN “stimulates” suppression. Proponents will parse it to “LDN works by stimulating an immune response.” Conveniently leaving off the end of the statement. “LDN works by stimulating an immune response to calm down or stop inflammatory immune responses (AKA – suppression).” Technically they are correct. By convention today, there is an agreement to only look at one aspect when publishing medical studies. They publish a study showing LDN works by stimulating a immune response. End of story. They assume those in the know reading this study would understand the consequences of this “stimulation.” However, the average person or Doctor(s)  (Don’t assume Doctors know much about the immune system) doesn’t know or care how it works. They only want to know will it give relief. Consequences be damned.

Fact: Inflammation is an immune response.

In answer to “a common anecdotal report is that people don’t get the common cold as much. Technically, they are correct. But??? They are equating not getting sick to a normal healthy immune system. After seeing the results from the Stimulated Cytokine lab test. I realized the reason they not getting sick is because their immune system is so fatigued or suppressed that no symptoms are generated. They come to my office reporting they feel like crap but they “never get sick”. “How can I be so healthy but feel so bad?”

Those using LDN usually report a blissful period where their inflammation (see fact above) subsides. Usually for a four to six month period; then other components of the immune system become overstimulated without the feedback control from the components that LDN suppressed. They have had half a year for smoldering inflammation doing further damage to their body. The good news is they will not feel it. The bad news is they will now seek help from a Doctor that will recommend immune stimulating supplements. Exacerbating the condition and the damage being done.

Alternative / Functional treatments focus on Stimulating the Immune Response.

Naltrexone Treatment by Immune Stimulation

A possible line of therapy being investigated by the medical community is to reintroduce some of these cytokines to people who have severe immune deficiencies.  This approach can be tricky because large amounts of any particular cytokine can have serious side-effects. This approach fails to recognize fatigued cells that are too exhausted to produce immune cells cause the deficiencies. How is stimulating the immune system beneficial?

The immune system by design provides your body with numerous layers of protection with a multiple backups. The system is set up so that if the responsible system is unable to handle the job and bigger, stronger system is recruited. Thus, if the basic Th1 or Th2 systems are fatigued to respond, the Th17 system is alerted to come in and take care of business.

Naltrexone Stimulation of the Immune System

Naltrexone treatment increases NK cell cytolytic activity and cytokine production in the spleen. Chronic naltrexone administration enhanced both basal and the cytokine-modulated NK cell cytolytic activity and IFN-γ production.

Naltrexone treatment increased the production of IL-2, IL-4, IL-6, and IL-18 and the basal and cytokine-activated NK cell cytolytic activity and IFN-γ production in the splenocytes. Chronic administration of naltrexone stimulates the production of cytokines and NK cell cytolytic activity in splenocytes. Naltrexone does not block IL-1β.,

Naltrexone Stimulation of NK cells

Natural killer cells are a T cells that share properties of both T cells and natural killer cells. NK cells can also produce many different cytokines as well as chemokines.  T cells are inherently cross-reactive, and this versatility and specificity is a hallmarks of adaptive immunity. T cells are prone to be autoreactive and thus able to induce autoimmunity.  Increasing the NK cell avtivity results in enhanced alloreactivity  and autoimmunity.

IL-2 promotes the differentiation of T cells into effector T cells and into memory T cells when the initial T cell is also stimulated by an antigen.

IL-2 does not specify the type of Th differentiation that occurs; instead, IL-2 modulates expression of receptors for other cytokines and transcription factors, thereby either promoting or inhibiting cytokine cascades that correlate with each Th differentiation state. In this fashion, IL-2 can prime and potentially maintain Th1 and Th2 differentiation as well as expand such populations of cells, whereas it inhibits Th17 differentiation but also can expand Th17 cells.

IL-2 has a narrow therapeutic window, and the level of dosing usually determines the severity of the side effects. Some common side effects:

  • Flu-like symptoms (fever, headache, muscle and joint pain, fatigue)
  • Nausea/vomiting
  • Dry, itchy skin or rash
  • Weakness or shortness of breath
  • Diarrhea
  • Low blood pressure
  • Drowsiness or confusion
  • Loss of appetite

More serious and dangerous side effects sometimes are seen with increased IL-2, such as capillary leak syndrome, breathing problems, serious infections, seizures, allergic reactions, heart problems or a variety of other possible complications.

T-cell recognition is essential for protection against microbial pathogens, recognition of self-peptides by T cells that have escaped negative selection in the thymus can lead to autoimmune disease. A disregulated T cell interaction can initiate autoimmunity. Thus, antigen recognition by T cells must be tightly regulated in order to ensure protection against pathogens and tumors, avoiding activation of self-reactive T cells.

NK cell cytolytic activity has been shown to be activated by interferon-γ (IFN-γ), which has a number of opioid-like effects. Various other cytokines are also known to increase NK cell cytolytic activity and lymphocyte proliferation. Of these cytokines, interleukin (IL)-2, IL-12, and IL-18 stimulate NK cell cytolytic activity. Other cytokines like IL-4 and IL-6 are known to regulate NK cell proliferation and differentiation. Cytokines IFN-γ, IL-2, IL-4, IL-6, IL-12, and IL-18 have been shown to also affect the function of other immune cell populations in splenocytes.

Alcohol consumption is also known to suppress Lectin-induced production of various cytokines, including IL-2, IL-6, and IL-4 from splenocytes. Initially, Naltrexone therapy counteracts the suppressive effects of alcohol on NK cell cytolytic activity for the first couple of weeks allowing increase production of IL-2, IL-6, and IL-4 from splenocytes.

Naltrexone Stimulation of Chemokines

Naltrexone is an opioid antagonist when administered the first couple of weeks, but shows δ-opioid-like activity following chronic long-term administration. With constant use naltrexone selectively promotes the δ-opioid receptor activity and enhances NK cell cytolytic activity response to β-endorphin. Naltrexone disrupts the feedback control that results in enhanced NK cell cytolytic response.

The chemokines, macrophage inflammatory protein-1 (MIP-1) and its subunit MIP-1 beta, induce an intense fever. The central action on body temperature (Tb) of MIP-1 beta with that of interleukin-6 (IL-6), has been implicated in the mechanism underlying the pathogenesis of fever along with etiocholanolone. This is potentiated by the presence of lipopolysaccharide.

Naltrexone increases in neutrophil-associated myeloperoxidase activity and chemokine mRNA expression, including macrophage inflammatory protein-1 alpha (MIP-1α) and -2 (MIP-2).

LDN could enhance both morphological and functional maturation of bone marrow dendritic cells (BMDCs). Their main function is to process antigen material and present it to the cell surface to the T cells of the immune system. They act as messengers between the innate and the adaptive immune systems. LDN markedly up-regulates expression of key surface molecules, which will trigger a chain of cell mediated responses. In addition to this, LDN also markedly upregulate production of cytokines IL-12 and TNF-α, which will trigger Th1 cell response.

Dendritic cells are present in those tissues that are in contact with the external environment, such as the skin (where there is a specialized dendritic cell type called the Langerhans cell) and the inner lining of the nose, lungs, stomach and intestines. They can also be found in an immature state in the blood. Once activated, they migrate to the lymph nodes where they interact with T cells and B cells to initiate and shape the adaptive immune response.

Interleukin (IL-1), tumor necrosis factor α (TNFα), IL-3, and IL-6 collaborate with GM-CSF. β-endorphin increased the number of macrophage colonies when bone marrow cells were cultured in the presence of GM-CSF plus lipopolysaccharide (LPS). Naloxone and Naltrexone, an antagonist of endorphins for opioid-receptors, completely abolishes the effect of β-endorphin. Both Naloxone and Naltrexone stimulates suppression of the production of GM-CSF.

Naltrexone Stimulates Suppression of Cytokines

Naltrexone and naloxone stimulates suppression of microglia activation, reduces the production of re- active oxygen species and other potentially neuroexcitatory and neurotoxic chemicals.

Naltrexone causes a significant decrease of IL-12 and IL-10 production by macrophages. With chronic dosages, IL-12 remaines significantly suppressed. As for IL-10, naltrexone seems to partially prevent the IL-10 reduction. Naltrexone significantly inhibited the production of TNF-alpha induced by LPS.

Naltrexone Stimulates Suppression of Chemokines

The anti-inflammatory effect of opioid antagonists naltrexone and naloxone also extend to the periphery, as evidenced by stimulates suppression of TNF-alpha, MCP-1, and other inflammatory agents in peripheral macrophages.

Stimulated Cytokine Testing on LDN Patient

The lab results shown below are from a woman using Naltrexone therapy. Despite feeling better on the Autoimmune protocol recommended to her, she stopped doing the Autoimmune protocol after deciding to start Naltrexone.

After starting the Naltrexone, things changed drastically. A lot of the old symptoms reappeared and some got worse. She was experiencing severe pain on right side of body from neck and shoulder down to her hip and ankle. Her low back was really bad, and she could hardly walk being constantly achy and sore. She could not get out of bed, and had diarrhea a couple of times a week. When she gets a flair up – it can occur for no reason and they are lasting longer. Unfortunately, she failed to mention the LDN therapy.

Naltrexone Induced Ischemia

Ischemia is a restriction in blood supply to tissues causing a shortage of oxygen and glucose needed for cellular metabolism (to keep tissue alive). Ischemia is generally caused by problems with blood vessels, with resultant damage to or dysfunction of tissue.

Neurons that demonstrate particular vulnerability to ischemic challenges have been termed “selectively vulnerable neurons”.  Of the entire brain, the neurons of the hippocampus are the most vulnerable.

This would result in problems with endocrine system, (thyroid, hormone, adrenal) as the blood-brain-barrier would be further compromised as a results of compromised (ischemic) blood flow to the pituitary, hypothalamus and hippocampus.

Exogenous ligands, i.e. naltrexone, that activate the δ receptors mimic the phenomenon known as ischemic preconditioning. Ischemia preconditioning/hypoxia preconditioning (IPC/HPC) is a phenomenon whereby brief ischemia/hypoxia “preconditions” cells and increases cellular resistance against subsequent lethal ischemia/hypoxia injury. Short periods of transient ischemia are induced the downstream tissues are robustly protected. This serves as a protective mechanism to restrict blood flow around an inflamed area of the body to prevent inflammation or microbes from spreading throughout the body. It is intended for short periods until the immune system is able to control the situation. If longer-duration interruption of the blood supply is then effected, ischemic damage from the lack of oxygen, glucose and elimination of cellular waste products occurs. Naltrexone and naloxone with δ activity mimic this effect.

Naltrexone Reduces Liver Enzymes

Naltrexone significantly reduces the elevation of serum glutamate-oxalacetate transaminase (SGOT) and glutamate-pyruvate transaminase (SGPT) (as index of hepatic function) induced by LPS.

Is LDN right for you?

The comments and posts you are reading saying how good they feel is because their immune status matches how LDN supports their imbalanced cytokines and chemokines. LDN works only for those with the correct immune status that Naltrexone or Naloxone supports.

If you do not match that cytokine or chemokine profile. LDN will only increase the damage and further disrupt your body’s ability to control the immune system. If you are using LDN and not satisfied with the way you are feeling. It is probably not right for you.

It is possible to get the immune system back under control. It is not a quick process but steady progress is experienced giving you the faith and confidence you need to know you did the right thing. One should never guess when it come to the immune system. Call today to have your Stimulated Cytokines and NEI Supersystem tested.

Are Edible Enemies contributing to poor health and inflammation? Lectins cause a plethora of damage to the body, promoting chronic inflammation and sensitivity. Take the Edible Enemy Quiz to test your knowledge on lectins.

Use the Lectin Control Formula to reduce the inflammatory response that occurs due to lectin consumption. Take two capsules with each meal.

Blue Blockers Stimulate the Chemical of Darkness

Melatonin is the ‘‘Chemical Signal of Darkness’’. Because the duration of melatonin production is the neurochemical signal for the annual change in night length,, wearing Blue Blocker Glasses increases the duration of the “biological night”.

Melatonin Is Linked to Antioxidants in Studies

If the only studies you read are linking melatonin to anti-oxidant and that is your only point-of-view. What could possibly go wrong with artificially increasing Melatonin through supplements or Blue Blocker Glasses. Melatonin like so many other hormones are “dose-dependent”. At “normal’ levels they do their normal duties. When they are too high or too low; the response is totally different and not in a good way.

Quick Summary of Melatonin Effects on the Body

  • Visible light decreases Melatonin levels.
  • Darkness increases Melatonin levels.
    • Blue Blocker Glasses increases Melatonin levels.
  • Melatonin is produced in multiple organs in the body.
  • Naturally occurring Melatonin increases Autoimmune cytokine storms and flairs during the Fall and Winter months.
    • Wearing Blue Blocker Glasses increases the amount of naturally produced Melatonin.
  • Melatonin lowers Thyroid Stimulating Hormone (TSH).
  • Melatonin Increases Polycystic Ovarian Syndrome (PCOS).
  • Melatonin increases the Th1, Th2 immune response response to antibodies.
  • Melatonin increases Th17 immune response
  • Melatonin increases parasite reproduction.

The amount of blue light in a natural environment varies depending on the time of the day (there is more in the morning) and on the reflecting surface such as snow, grass, water, sand or cement, blue blockers which are cutting all wavelengths below 540 nm are effective in naturalistic condition albeit that proper glasses frame are made to cover all angles.

Blue Blocker Glasses cutting the blue portion of the light spectrum with orange lens glasses prevent the light-induced melatonin suppression, thereby increasing the production of melatonin. Blue Blocker Glasses represent an elegant means to increase melatonin production.

The immune system shares the same sensitivity to wavelengths as melatonin (as demonstrated by others using phase-shifting protocols,,,,, when these glasses are worn in the morning, greatly impede resynchronization of the biological clock by light.

There is a dose–response relationship between light intensity or irradiance and melatonin suppression.,,, Melatonin suppression is wavelength dependent with a peak sensitivity in the 446–477 nm (blue light) portion of the visible spectrum., Accordingly, it is possible to control the effect of light on the immune system by blocking the blue portion of the visible light.

A person’s prior light history has an impact on melatonin suppression or production., Those suffering from autoimmune disease are more likely to seclude themselves in dark rooms. Unknowingly, increasing their melatonin production and increasing their immune system reactivity.

The capacity of Blue Blocker Glasses to increase melatonin is sufficient to induce maximal melatonin suppression and about the same as encountered easily in the morning while driving.

Melatonin enhances the immune response.,, Melatonin supplementation or melatonin increasing Blue Blocker Glasses of both normal and immunocompromised individuals increases antibody responses and T helper cell activity., Melatonin administration appears to stimulate humoral immunity during early B cell development in the bone marrow. Melatonin has immune-enhancing effects and can exacerbate autoimmunity.

Melatonin Enhances the Immune Response

Short, winter-like photoperiods enhance immune function relative to those exposed to long, summer-like days. The seasonal changes in immune function is due to changes in the melatonin levels.

 

The physiological properties of melatonin are not limited to its neuroendocrine role in controlling circadian rhythms; several other actions have been discovered. Melatonin has been shown to increase innate and acquired immunity, to activate the bone marrow and lymph nodes, to enhance NK cell activity and antibody-dependent cell cytotoxicity, to increase T cell proliferation and to activate monocytes and neutrophils. Melatonin can stimulate innate immune cells, primarily leukocytes, which represent an important anti-bacterial mechanism.

Th17 (harm) and Treg cells (protection) are both involved in the harm/protection balance of immune conditions such as autoimmunity or acute transplant rejection (miscarriage). The differentiation of Th17 using melatonin supplementation or melatonin inducing Blue Blocker Glasses aggravates autoimmune diseases and/or can induce serious complications in pregnancy.

Melatonin enhances the immune response. A large body of evidence supports the immunoenhancing role of melatonin. Exposure to short days (<12 h light/day) or daily melatonin supplements or melatonin increasing Blue Blocker Glasses may increase the size of the spleen. Melatonin enhances both cell-mediated and humoral immune function.

Melatonin supplementation or melatonin increasing Blue Blocker Glasses of both normal and immunocompromised individuals increases antibody responses and T helper cell activity. Melatonin administration appears to stimulate humoral immunity during early B cell development in the bone marrow.

Melatonin supplements and/or treatment for extended duration (e.g., Blue Blocker Glasses) induces physiological adaptations associated with winter, including reproductive regression and enhancement of certain aspects of immune function. In healthy individuals, melatonin has anti-inflammatory effects, while in those with Autoimmune conditions, melatonin is pro-inflammatory.

The Link Between Hashimoto’s Thyroiditis and the Herpes Rash?

DH popoosThe link between Hashimoto’s and the Herpes rash is this. If you have any thyroid issue whether it is Hashimoto’s, low thyroid or hyperthyroid. You will have an issue with gluten sensitivity.

Is Your Herpes Break Out Really a Gluten Rash?

Are you suffering from occasional herpes out breaks on areas of your body but not on the genitals?  Those with a sensitivity to gluten, often develop blistering rashes that are often mistaken for a herpes outbreak.

A Local Dermatologist told us he is upsetting the GI docs because he is diagnosing gluten sensitivity/celiac more than they are. He is sending patients out to be tested for gluten sensitivity/celiac when he sees these blistering rashes. He says if the fluid from one of these blisters is collected and tested it comes back very frequently positive for gluten sensitivity. However, most these rashes are so itchy, patients scratch and break the blisters before it can be collected.

Call today! 530-615-4083

Are you frustrated because the herpes medication doesn’t seem to control it or provide any relief? A good way to control the outbreaks would be to identify the causes, and take effective measures to ensure that they remain out of your daily life. How was your herpes diagnosed? What if your herpes outbreak wasn’t caused by virus. What then?

Dermatitis Herpetiformis

Dermatitis herpetiformis (DH), an itchy, stinging, blistering skin rash, occurs when your skin reacts to gluten antibodies circulating in your system. Some people call dermatitis herpetiformis a “gluten rash” or a “celiac disease rash” because it occurs in conjunction with a sensitivity to gluten. Regardless of the presentation or symptoms, a positive diagnosis of DH always indicates that a gluten sensitive enteropathy is occurring.

DH back sideDermatitis herpetiformis (DH) can often be misdiagnosed and frequently confused with skin conditions such as: allergies, bug or mosquito bites, contact dermatitis, diabetic pruritus, eczema, herpes, shingles, hives and psoriasis.

DH faceReddened skin, circular bumps, and blisters filled with clear, neutrophil (white blood  cell), containing liquid are very common. Skin lesions and scarring can also appear, particularly in patients that scratch and irritate the skin during outbreaks.

The onset of DH may be acute or gradual, appearing in the same location every time. DH outbreaks are very often mirrored, meaning that the rash will occur on both sides of the body in exactly the same place. The hallmark sign of DH is an intensely itchy, blistering skin rash.

DH can appear anywhere on the body; however, It most frequently present in the following areas:

  • Buttocks
  • Elbows
  • Knees
  • Lower back
  • Scalp


Dermatitis herpetiformis sufferers usually experience to rash in the same location every time. The rash might be continuous, or it might come and go.

DH skinBefore the actual dermatitis herpetiformis breaks out, your skin may itch in that location, or it might feel is if it’s burning.  The rash itself usually includes reddened skin plus multiple small, pimple like-bumps which contain a clear liquid.

The dermatitis herpetiformis bumps usually take several days to heal (during which time new bumps usually appear nearby), and once healed, only behind small purple marks that lasts for weeks or months.  People with long-standing dermatitis herpetiformis usually have continuously reddened skin where the rash occurs.

As the name implies, dermatitis herpetiformis (DH) looks herpetic and is sometimes mistaken for a herpes virus. Red plaques erupt in groups of blisters, in the resulting intense itch can disturb sleep.

Who does dermatitis herpetiformis affect?

DH lipsUnlike gluten sensitive enteropathy or celiac disease, which is diagnosed more often in women, dermatitis herpetiformis is more common in men. In fact, some studies show a male-to-female ratio of up to 2-to-1 in dermatitis herpetiformis patients. Men are more likely to have a typical oral or genital lesion.

DH can affect people of all ages but most often appears for the first time between the ages of 15 and 40. People of northern European descent are more likely than those of African or Asian heritage to develop DH.

Dermatitis Herpetiformis is an autoimmune blistering disorder associated with a gluten sensitive enteropathy. People with DH have a condition of the intestinal tract identical to that found in gluten sensitive enteropathy or celiac disease, although gastric symptoms might be absent. Autoimmune processes can be arrested if the interplay between the Neuro-Endo-Immune Supersystem and environmental triggers is prevented by re-establishing intestinal barrier function.

How does a disorder that damages the intestines show up on the skin?

When a person has gluten sensitive enteropathy consumes gluten, the mucosal immune system in the intestines responds by producing a type of antibody called Immunoglobulin A. As IgAs enters the bloodstream, they can collect in small vessels under the skin, triggering further immune reactions that result in the blistering rash of DH.

DH handThe first clue that a skin eruption may be DH is that “it itches like crazy.” People are digging at themselves. As a result the blisters are almost always broken open by the time the DH suffer seeks medical help.

The second characteristic sign of DH is its location on the body. Lesions most often appear on the extensor surfaces – the forearms near the elbows, the knees, and the buttocks. The outbreak of the lesions also tends to be bilateral, meaning it appears on both sides of the body.

The grouping of the lesions provides a final clue. Although DH is not caused by a herpes virus, its lesions resemble those of herpes and hence the word herpetiformis. In both conditions, lesions are formed in small groups. Still, DH is often confused with eczema, a common inflammatory skin disorder that, like DH, results in an itchy rash that is often scratched raw.

A gluten sensitive enteropathy is different from celiac disease in that a gluten sensitivity is the result of a microscopic colitis. The damage to the gastrointestinal lining in microscopic colitis is not bad enough for a biopsy or endoscopy to see enough damage to be called celiac disease. Many patients report they have been checked by their doctor and were told their lining was red or irritated. So they did not have a gluten sensitivity because they did not have celiac. Many healthcare providers also assume a person’s immune system is always working at 100% optimal efficiency. When in fact, the immune system is so fatigued from constant exposure to gluten. It cannot create a response in the normal fashion.

Breaking with BreadDH breaking bread

A strict gluten – free diet may take weeks to clear up an outbreak. Accidental ingestion of gluten will cause symptoms to recur. Hidden sources of gluten can prolong the outbreak.

For some it will be as easy as maintaining a gluten free lifestyle. Others will require our help in quenching the immunoglobulin reaction, controlling the immune response, restoring the digestive chemistry and repairing the gastrointestinal lining to enable them to maintain themselves through diet and lifestyle.

Call to schedule a free 15 minute consultation.

Call today! 530-615-4083

 

The Bowel Truth: What Stools Will Tell About Your Health

The human gut is almost unique amongst mammals – the upper gut is a near sterile, chemically digesting carnivorous gut (like a dog’s or cat’s) to deal with meat and fat, while the lower gut (large intestine) is full of bacteria and is a fermenting vegetarian gut (like a horse ‘s) to digest vegetables and fiber.

Stools Can Reveal A Lot About Your Health

Can you believe that you can tell a lot about your health just by looking at your stool? Have you ever heard of the ISWA? (International Stool Watchers Association) You won’t find it on the Internet. It’s a “secret organization.” Believe it or not, this is a popular search engine topic so you should know you might have friends in the ISWA. From your stool you may be able to get clues about your diet, your gastrointestinal health, and even whether your stress, anger, or anxiety levels are too high.

HOW FOOD BECOMES STOOL

No matter how nutritious, your favorite foods won’t do you any good in the natural whole state. From the moment food enters your mouth, your body embarks on a campaign to turn it into a soupy mush called chyme. Chewing, saliva, peristalsis (the involuntary contractions of gastrointestinal muscles), bacteria, hydrochloric acid, pancreatic enzymes, bile, and other secretions all work to give each meal the consistency of split pea soup.

Digestion is the process by which nutrients are extracted from food and absorbed by the body. Mechanical digestion involves food being chewed and swallowed while stimulating the chemical digestion. Mechanical digestion processes – such as chewing, swallowing and the muscular movements that mix and move food through the digestive tract – supports the chemical digestion by physically breaking down whole food into smaller pieces to facilitate chemical breakdown. Chemical digestion is required to process and extract nutrients from food that the body needs to survive and thrive. Chemical digestion is responsible for sterilizing food entering the body and maintaining the environment that controls microbial behavior. Without chemical digestion, the body would be unable to properly eliminate excess food waste. It is the digestive chemistry that keeps the upper digestive tract bacterial numbers low, not the immune system.

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Fermentation is the digestive process by which carbohydrates are broken down by microorganisms into simple molecules for absorption into the bloodstream. Some fermentation takes place throughout the gastrointestinal tract, but the intensity of fermentation depends on microbial numbers, which are generally highest in the large intestine. Thus, the large intestine is quantitatively the most important site of fermentation, except for the species with forestomachs (ruminants like cows), which for cows helps them to be successful vegetarians. People are monogastric, meaning one stomach, (cows have four stomachs and spend their days regurgitating and chewing the grass over and over), relying on digestive chemistry to extract the majority of the nutrients.

Digestion of food must occur in a specific sequence and order. There are four overlapping phases that convert food into stool. Each phase stimulates the next step, like dominos. Miss a step and digestion is impaired. Just like removing a domino causes the chain reaction to stop, even if you are eating organic, vegan or grass-fed. I am surprised at how many think because they are eating “healthy” their digestive processes are working at optimal efficiency.

Thought & Smell

First, the thought of being hungry and the smell of food cooking stimulates the saliva glands and the gastrointestinal hormones made in the pituitary that stimulate the stomach, pancreas and upper digestive tract. Our bodies need the time to produce the digestive chemistry, i.e. stomach acid & enzymes, pancreas juices and enzymes and bile from the gallbladder. The smell and thought of food starts the process.

We have been taught that odors are bad. How many home deodorizers are on the market? Then add to that pre-packaged microwave meals which are also devoid of any food odor. Flowery home deodorizers are not conducive to good digestion. Microwaved food may smell somewhat like food when the package is opened but it doesn’t provide your body with the time it needs to prepare the digestive chemistry. Yet what happens when you walk into a home with the smell of cooking food? That food tastes so much better. Why? Because your body is better prepared for it. Unfortunately, the most common answer I get during a consultation is that they don’t know how to cook because they grew up using the microwave. Thank God for Alton Brown on the Food Network doing shows on how to cook.

Mash & Mix

Next, there is Mash & Mix where the upper teeth serve as the anvil and the lower teeth are the hammers that break down big pieces of food into smaller pieces. Too many are using the 1-2-3-gulp method during this phase.  This leaves the food like chunky salsa. Food should be mashed to more of a fruit smoothie texture. This is where the digestive chemicals begin to be mixed in. The chemicals work on the surface of the food and can only soak in so far. Remember, when you made the Nestle’ Quick and when you got to the bottom of the glass there was a big blob of chocolate powder. Did you ever take a spoon and mash it and find the inside of the blob dry? The milk didn’t penetrate the interior. The same happens when you use the 1-2-3-gulp method. Leaving the chunks of food in your digestive tract not chemically processed at 98.6 degrees for hours or days. How long can you leave food out on a hot summer day before it starts to go bad?

Chewing stimulates the stomach, pancreas and gallbladder to prepare for the arrival of food. Think of chewing as foreplay for digestion. Without the chemistry, the system is dry and there is an insufficient quantity of digestive chemicals to break down the amount of food eaten. But before the food is broken down chemically, it is sterilized. The upper gut is a near sterile environment. Stomach acid kills the alkaline-loving bacteria and microbes. Most disease causing microbes love an alkaline environment. Pancreas juices and bile sterilize the acid-loving bacteria and microbes. This combination keeps the number of microbes in the upper digestive tract at a low level giving the chemicals the time necessary to act on the food.

Most disease causing microbes love an alkaline environment. Think about that when you alkalize your system.

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The digestive chemistry controls the environment of the gastrointestinal tract. The environment controls the behavior of the microbes. It is not simply an issue of good vs. bad bacteria. A healthy gut environment will have well behaved bacteria that work with and for the body. Just as a ghetto controls the behavior of those who live there as even good bacteria in a ghetto gut will change their behavior and become detrimental to health. This includes probiotic and fermented food bacteria.

Mix, & Absorb

Mixing movements occur in the gastrointestinal tract as a result of smooth muscle contractions. These repetitive back and forth contractions usually occur in small intestine and mix the food particles with the digestive chemistry and other fluids. These contractions are stimulated by the production of serotonin by cells lining the small intestine. Ninety-five (95%) of serotonin is made in the gut for peristalsis and control of the blood supplying the gut. The movements that propel the food particles through the GI tract are called peristalsis. These are rhythmic waves of contraction that move the food particles through the various regions in which mechanical and chemical digestion takes place.

The small intestine is the part of the gastrointestinal tract between the stomach and large intestine and is where much of the chemical digestion of food occurs. Virtually all nutrients from the diet are absorbed into blood across the lining of the small intestine. In addition, the intestine absorbs water and electrolytes, thus playing a critical role in maintenance of body water and acid-base balance.

The bowel is made up of the small and large intestines. The small intestine includes three sections—the duodenum, jejunum, and ileum. In the ascending and transverse colon much of the water, electrolyte and sugar balancing occurs between the inside and outside world, except for, perhaps the kidneys. It is also in this area that the symbiotic (living mutually together) bacteria live. It is reasonable, therefore, that their products should be absorbed from this area.

You may have specific nutrient deficiencies depending on which sections of the small  or large bowel are not functioning properly or were removed.

The sites of nutrient absorption in the small bowel are the:

  • Upper section (duodenum), where iron is absorbed
  • Middle section (jejunum), where carbohydrates, proteins, fat, calcium and vitamins are absorbed
  • Lower section (ileum), where bile acids and vitamin B-12 are absorbed

The nutrient absorption in the entire length of the large bowel is the:

  • Salts and electrolytes. Mainly sodium and potassium.
  • Water
  • Dissolved minerals
  • Vitamin K
  • Biotin
  • Vitamin D
  • Folic acid
  • Many of the B vitamins in small quantities.

Without these nutrients, the blood is chemically unbalanced, a condition that can lead to illness and chronic poor health.

Ferment, Absorb & Eliminate

Fermentation: The cells lining the large intestine do not produce enzymes, but contain huge numbers of bacteria, which have the enzymes to digest and utilize the substances the enzymes produce. The microbial floras of the large intestine are primarily responsible for two processes:

  • Digestion and metabolism of carbohydrates not digested in the small intestine.
  • Synthesis of vitamin K and certain B vitamins

Cellulose is the fiber in the diet, but no human cell is known to produce a cellulase, an enzyme that breaks down fiber for digestion. Several species of bacteria in the large intestine produce cellulases and digest celluose. Importantly the major end products of microbial digestion of cellulose and other carbohydrates are volatile fatty acids, lactic acid, methane, hydrogen, carbon dioxide and hydrogen sulfide. Fermentation is the major source of intestinal gas.

Volatile or short-chain fatty acids (especially acetic, propionic and butyric acids) generated from fermentation are not only generated from fermentation within the intestinal lining, but can be absorbed by diffusion and contribute to systemic metabolism and other metabolic processes.

The job of the large intestine is to absorb water and salts from the material that not been digested as food and get rid of any waste products left over. By the time the food mixed with digestive juices reaches your large intestine, most digestion has already taken place. What’s left is mainly fiber or plant matter that takes a long time for bacterial digestion to occur.

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While your digestive cells are absorbing sugars, starches, fats, vitamins, minerals, and other nutrients, waste products continue traveling down the line. In the colon, all the leftovers are combined, packed together, and partially dehydrated. What remains – our feces – consist of water, indigestible fiber, undigested food (such as corn and small seeds), sloughed-off dead cells, living and dead bacteria, intestinal secretions, and bile. (The worn-out red blood cells in bile give excrement its distinctive brown color.) In the large intestine, bacteria feed on this mixture. These helpful bacteria produce vitamins that are absorbed into your blood.

Proper blood supply to the intestinal tract

The blood supply to the gastro-intestinal tract must be whole and intact to allow proper assimilation of the absorbed materials into the body. This is controlled through the Vasomotor components of the NEI Supersystem. Read More … Any damage to, or scarcity of blood supply from whatever cause, will limit the effectiveness of absorption.

The main function of the the enteric nervous system is to coordinate the movement of food through the gut (peristalsis) and trigger the release of the appropriate hormones and enzymes that are necessary for digestion and controlling blood flow in the gut wall which is important for the absorption of nutrients.

The two parts of your automatic nervous system (Autonomic nervous system) control the blood supply to the organs. The “Rest & Digest” Parasympathetic stimulation will increase overall blood flow to the gut as well as increasing secretions and general gut activity. The “Fight or Flight” Sympathetic stimulation will have the opposite effect. Most people with chronic health issues are Parasympathetic dominant with their blood pooling in the mesenteric veins.

Symptoms of Excess Sympathetic / Deficient Parasympathetics

* Anxiety-like response     * Enlarged pupils     * High blood pressure

* Infrequent bowel movements     * Nervous strain

* Tension headaches     * Irritability     * Indigestion

* Rapid heartbeat with palpitations or weak pulse

* Nightmares     * Muscle tension

Symptoms of Excess Parasympathetic / Deficient Sympathetics

* Sluggish/poor digestion     * Lethargy/fatigue     * Cold hands/feet

* Low blood pressure     * Small pupils     * Sweats easily

* Sensitive to noises and touch     * ADHD     * Mental confusion

* Difficulty concentrating     * Restless sleeping     * Urination at night

* Hemorrhoids – Internal and/or External

What Does an Ideal Bowel Movement Look Like?

13776699_sIf all goes, as it should, you’ll end up with a healthy bowel movement. Although digestive idiosyncrasies, variations in intestinal bacteria, and other variables can produce different standards for a healthy stool, in general it should be brown to light brown; formed but not hard; cylindrical, not flattened; fairly bulky and full-bodied, not compacted; somewhat textured but not too messy; and very easy to pass. And it shouldn’t smell – much. You’re passing methane and bacterial, degraded foodstuffs, so there’s always going to be a little odor, but it shouldn’t be a very strong, pungent odor.

An ideal bowel movement is medium brown, the color of plain cardboard. It leaves the body easily with no straining or discomfort. It should have the consistency of toothpaste, and be approximately 4 to 8 inches long. Stool should enter the water smoothly and slowly fall once it reaches the water. There should be little gas or odor.

Experts Disagree On Two Stool Characteristics: FLOATING versus SINKING?

Opinion A) Stools should float because buoyancy is a sign that the body has absorbed the minerals in the food and that these nutrients are not contained in the waste.

Opinion B) Stools should sink because of their bulk and fiber content.

I am not impressed with either argument: most stools will sink. Whether it floats or sinks really doesn’t seem to make any difference. An occasional deviation from this total picture is usually considered okay; chronic deviations (or any featuring blood) are not, and should be checked with a doctor.

Stool That Sinks Quickly

Rapidly sinking stool can indicate that a person isn’t eating enough fiber-rich foods, such as vegetables, fruits, and whole grains, or drinking enough water. This stool is often dark because they have been sitting in the intestines for a prolonged time. Only members of the International Stool Watchers Association (ISWA) with advanced skills will be able to determine if their stool sinks rapidly.

What Are Floating Stools?

Stools normally sink in the toilet. However, a variety of things, mainly diet, can cause a change in your stools. Changes to the structure of your stools may result in floating. Occasional floating stools are usually nothing to be concerned about. Your stools will most likely return to normal without any treatment. Floating stools are not an illness or disease; however, they can be a symptom of some illnesses and diseases.

Common Causes of Floating Stools

The most common causes of floating stools are excess gas and fats in the stool. Both provide buoyancy to the stool preventing it from sinking. Pancreas and Gallbladder problems cause malabsorption of fat. Increased fat in the stool will cause them to float.

Certain foods are easily fermented by bacteria and can cause gas in your stools. Foods that ferment and the resulting gas include those that contain large amounts of sugars, lactose, starch, or fiber, such as beans, milk, cabbage, apples, soft drinks, and sugar-free candies. This can indicate a microbial overgrowth.

Fat malabsorption is a condition that results in a very limited ability of the body to absorb fats in the gastrointestinal tract. Fat malabsorption can result in a deficiency of the fat-soluble vitamins A, D, E and K. It can be caused by a number of underlying conditions, such as impaired gallbladder function, liver dysfunction, pancreas exocrine insufficiency.

Malabsorption can occur when your stools pass through your intestines too quickly, such as when you have diarrhea. Malabsorption can also occur when your body does not process and absorb fats correctly.

Malabsorption of Fat Due to Pancreatic Insufficiency

Diarrhea is a common problem and presents as loose, watery, oily or foul-smelling stools that can be caused by insufficient amounts of pancreatic enzymes in the intestines. This leads to malabsorption as undigested food passes quickly through the digestive tract.

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If you have severe malabsorption, your floating stools may also have a strong odor and be greasy in appearance. A common cause of malabsorption is gastrointestinal (GI) tract infections as the bacteria change their behavior, producing more toxins than nutrients. GI tract infections can be caused by viral or bacterial infections. These infections usually go away without any treatment.

Some of the diseases that can cause floating stools include:

Atrophic gastritis

Atrophic gastritis is a process of chronic inflammation of the stomach mucosa, leading to loss of gastric glandular cells and their eventual replacement by intestinal and fibrous tissues. As a result, the stomach’s secretion of essential substances such as hydrochloric acid, pepsin, and intrinsic factor is impaired, leading to digestive problems, vitamin B12 deficiency, and megaloblastic anemia and a failure to stimulate the pancreas, gallbladder and liver to process fats. It can be caused by persistent infection with Helicobacter pylori, or can be autoimmune in origin. Those with the autoimmune version of atrophic gastritis (Autoimmune Atrophic Gastritis) are statistically more likely to develop gastric carcinoma, Hashimoto’s disease, achlorhydria, and pernicious anemia.

Short Bowel Syndrome

Short Bowel Syndrome (SBS) is when the intestines do not absorb nutrients properly. This can occur due to intestinal disease or when part of the small intestine is missing from either a genetic defect or surgical removal. Most overlook the un-named intestinal disease contribution to Short Bowel Syndrome considering it only with a named intestinal disease, i.e. Celiac, Crohn’s, or IBS. Chelation therapy poisons the bowel lining causing not only SBS but also Barren Gut Syndrome (BGS). BGS occurs when the lining of the intestines is so damaged beneficial bacteria have no place to adhere to.

Short Bowel Syndrome (SBS) is defined as malabsorption resulting from anatomical or functional loss of a significant length of the intestines (small or large). Short-bowel syndrome is a disorder clinically defined by malabsorption, diarrhea, steatorrhea, fluid and electrolyte disturbances, and malnutrition. The final common etiologic factor in all causes of short-bowel syndrome is the functional or anatomic loss of extensive segments of intestines so that absorptive capacity is severely compromised. The amount of bowel that must be lost to produce malabsorption is variable and depends on which section(s) is/are lost, and whether the ileocecal valve is functioning.

What are the signs and symptoms of short bowel syndrome?

Chronic diarrhea is the classic symptom of severe short bowel syndrome. Other symptoms may include:

  • Cramping
  • Bloating
  • Heartburn
  • Weakness and fatigue
  • Dehydration
  • Pale, greasy, watery diarrhea
  • Particularly bad-smelling stools
  • Weight loss
  • Exhaustion
  • Food sensitivities
  • Fluid retention
  • Malnutrition
  • Pain in the stomach or abdomen
  • Indigestion

Because of the body can’t absorb enough nutrients, patients with short bowel syndrome often exhibit symptoms of nutrient and vitamin deficiencies, such as:

  • Anemia due to iron, folic acid, and/or vitamin B12 deficiency
  • Skin rashes and scaling of the skin or hyperkeratosis due to vitamin A deficiency
  • Bruising and blood in urine, due to vitamin K deficiency
  • Muscle spasm and bone pain, due to vitamin D and calcium deficiency
  • Osteoporosis due to calcium deficiency

Children diagnosed with short bowel syndrome are also often slow in growth or development, due to lack of nutrition.

Lectins and Short Bowel Syndrome

Dietary lectins naturally occurring in all legumes, grains, fruits and vegetables are highly toxic to the gastrointestinal lining from the mouth to the large intestine. Biologically irritating to the cells, lectins cause the lining to thicken while increasing the porousness by damaging the connections holding the cells together. Thus contributing to Short Bowel Syndrome. The cells can no longer absorb nutrients but toxins, microbes and food particles pass between making their way in to the blood provoking an inflammatory response. Most of the time the inflammatory response is the TH17 cytokine storm. Lectins stimulate the release of gut hormones that shut off chemical digestion and the mixing movement of the stomach, small intestine and large intestine.

[youtube https://www.youtube.com/watch?v=S5F7DlrG2XE]

 

Are Edible Enemies contributing to poor health and inflammation? Lectins cause a plethora of damage to the body, promoting chronic inflammation and sensitivity. Take the Edible Enemy Quiz to test your knowledge on lectins.

Use the Lectin Control Formula to reduce the inflammatory response that occurs due to lectin consumption. Take two capsules with each meal.

Use Registration Code: DP283 to get access to the Doctor’s Supplements Store.

Get your “Autoimmune Diet Lectin Avoidance Guidelines” eBook

Click on this image to get your Autoimmune Diet Lectin Avoidance Guidelines eBook.

Lactose Intolerance

Floating stools commonly occur in people who have lactose intolerance when they drink or eat dairy products. Lactose intolerance is the inability to digest lactose, which is a sugar found in dairy products. Ingesting dairy products when you are lactose intolerant can cause gas in your stools and diarrhea, which can lead to malabsorption.

Celiac Disease

Celiac disease is an autoimmune disease that causes damage to the lining of the small intestine when gluten is eaten. An autoimmune disease is one in which your body’s immune system mistakenly produces substances (antibodies) to attack your own tissues. Gluten is a protein found mainly in wheat products. Celiac is an inherited disease. Symptoms of the disease can begin in childhood or adulthood. There is no cure for celiac disease. The symptoms go away when gluten is avoided.

Cystic Fibrosis

Cystic fibrosis is an inherited and often fatal disease that causes an excess production of thick and sticky mucus in the lungs and digestive tract. The excess mucus in the pancreas prevents the proper absorption of nutrients, which can cause floating stools. There is no cure for cystic fibrosis. Treatments, including medications, may reduce floating stools, as well as other symptoms of the disease.

Other

Extremely rare genetic diseases that can cause floating stools include:

  • Bassen-Kornzweig syndrome (a genetic disease in which the intestines cannot absorb fat)
  • biliary atresia (underdeveloped bile ducts, which make the intestines less able to absorb fats)
  • disaccharidase deficiency (a deficiency or absence of enzymes, such as sucrase and isomaltase, which are needed to break down some sugars and starches)

Preventing Floating Stools

If you have floating stools, but no other symptoms, you may want to try a home treatment. There is a good chance that your floating stools are caused by your poor chemical digestion rather than diet. Keep a record of the foods that you eat and your bowel movements. Take note when you have floating stools. When you do have floating stools, look to see what foods you recently ate. If you continually keep a food intake and bowel movement record, you may be able to identify which foods cause your floating stools. Once you identify the offending foods, you can determine which phase of your digestive process is not working properly.

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The Number Of Pieces And Their Buoyancy

WHOLE OR PIECES?

Bristol Stool Chart

a) Each bowel movement preferably should be in one piece, about the shape and size of a banana and tapered at the end.

b) Stools don’t have to be well-formed logs. They can disperse in the toilet water; they can break down.

Stool Color

If Your Stool Looks BLACK, TARRY, AND STICKY It Could Mean:

  • Bleeding in your upper digestive tract. The black color comes from digested blood cells.

If Your Stool Looks VERY DARK BROWN It Could Mean:

  • You drank red wine last night or have too much salt or not enough vegetables in your diet.

If Your Stool Looks GLOWING RED OR MAGENTA It Could Mean:

  • You’ve eaten a lot of reddish foods such as beets.

If Your Stool Looks LIGHT GREEN It Could Mean:

  • You’re consuming too much sugar, or too many fruits and vegetables with not enough grains or salt.

If Your Stool Looks PALE OR CLAY-COLORED It Could Mean:

  • Minimal amounts of bile are being excreted, perhaps because of problems with the gallbladder or liver.
  • Stool that is pale or grey may be caused by insufficient bile output due to conditions such as cholecystitis, gallstones, giardia parasitic infection, hepatitis, chronic pancreatitis, or cirrhosis. Bile salts from the liver give stool its brownish color. If there is decreased bile output, stool is much lighter in color.
  • Other causes of pale stool is the use of antacids that contain aluminum hydroxide. Stool may also temporarily become pale after a barium enema test.

If Your Stool Looks BLOODY OR MUCUS-COVERED It Could Mean:

  • Hemorrhoids, an overgrowth of certain bacteria in your gastrointestinal tract, colitis (inflammation of the colon), Crohn’s disease (also known as inflammatory bowel disease), or colon cancer.
  • Red blood usually means the ailment is located near the end of your digestive tract, whereas black blood signals partially digested blood coming from an ailment higher up the tract. Seek medical advice promptly.

If Your Stool Looks PENCIL-THIN AND RIBBONLIKE It Could Mean:

  • A polyp or growth in your colon that narrows the passage for stool.
  • Spastic colon. It can also be from a prolapse at either side of the transverse colon constricting the colon and lack of fiber.

If Your Stool Looks LARGE AND FLOATING, WITH GREASY FILM ON TOILET WATER It Could Mean:

  • Malabsorption — your digestive system isn’t getting full nutritional use of food.

If Your Stool Looks LOOSE AND WATERY, SOMETIMES DIARRHEA WITH UNDIGESTED FOODSTUFFS It Could Mean:

  • Possible causes are food poisoning, lactose intolerance, antibiotics, antacids, dietary intolerance, dietary changes, travel, anxiety, stress, inflammatory bowel disease, or irritable bowel syndrome.

If Your Stool Looks SMALL, HARD, ROUND PELLETS It Could Mean:

  • Constipation – even if you’re defecating frequently.
  • Possible causes are eating too much dry food, including protein, and not enough vegetables and raw foods; laxative abuse; worries; or irritable bowel syndrome.

If Your Stool (Has) ALTERNATING BOUTS OF DIARRHEA & CONSTIPATION It Could Mean:

  • Irritable bowel syndrome. This chronic condition can be aggravated by red meat, spices, sugar, alcohol, lack of fiber, allergy-causing foods, irregular hours, and chaotic relationships.

If Your Stool (Is) REALLY BAD SMELLING It Could Mean:

  • An imbalance of intestinal bacteria or eating too much animal protein, which can putrefy in your digestive tract.
  • An overgrowth of Sulphate-Reducing Bacteria.

Are Edible Enemies contributing to poor health and inflammation? Lectins cause a plethora of damage to the body, promoting chronic inflammation and sensitivity. Take the Edible Enemy Quiz to test your knowledge on lectins.

Use the Lectin Control Formula to reduce the inflammatory response that occurs due to lectin consumption. Take two capsules with each meal.

Use Registration Code: DP283 to get access to the Doctor’s Supplements Store.

Get your “Autoimmune Diet Lectin Avoidance Guidelines” eBook

Click on this image to get your Autoimmune Diet Lectin Avoidance Guidelines eBook.

Call today! 530-615-4083