Am I TH1 or TH2 or TH17?

Some practitioners recommend the Th1/Th2 Challenge to determine if symptoms are immune related. Doing the Th1/Th2 Challenge is like checking for a gas leak with a burning match. It doesn’t account for Th17. Are you a woman suffering from inflammatory fire searching the internet for answers? I often hear from women that they have to be their own advocates for their health. I agree you must be your own advocate.

Inflammation is a general term describing the effects of too many inflammatory cytokines and stimulating neurotransmitters unopposed by too few anti-inflammatory cytokines and inhibitory neurotransmitters.

Finding Your Immune Status

For more than thirty years, T-Helper (TH) cells have been divided by immunologists into two functional subsets: T-helper-1 (TH1) and T-helper-2 (TH2). Immunologists have also identified specific groups of chemical messenger molecules called “cytokines and chemokines” that are used to communicate between the cells of the immune system and stimulate eith the TH1 or TH2 system.

TH1/TH2 Challenge

When the activity of one subset goes up, it represses the activity of the other similar to a seesaw or teeter-totter. Some practitioners recommend the TH1/TH2 Challenge to determine if symptoms are immune related. In this test, one immune stimulating supplement is taken at a time and a journal is kept of the symptoms experienced. One supplement stimulates the TH1 side of the immune system, and the other supplement stimulates the TH2. The reactions to these supplements are used to determine which side of your immune system is out of balance. However, very few people are strictly TH1 or TH2.

Fig. 1: Provocation of Unregulated Immune Response

Very Few People Are Strictly TH1 or TH2.

People with similar symptoms can have remarkably different laboratory results, while people with comparable laboratory results often exhibit widely different symptoms. This leads to confusion and frustration when doing immune challenges. Results from the Neuroscience NEI Gold 5516 for women suffering from Hashimoto’s show how confusing and unpredictable it can be.

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Fig. 2: Immune Status Scale

Immune Status Scale

Many consider the immune system to be always working properly, even with autoimmune conditions. When it is actually compromised and experiencing the effects of too many inflammatory cytokines and stimulating neurotransmitters unopposed by too few anti-inflammatory cytokines and inhibitory neurotransmitters, while being hacking into and disrupted by microbes, bacteria and parasites.

Another favorite is to blame food or something from the environment. While they can and do serve as provocateurs in an Immune compromised individual. Microbes, bacteria and parasites hack into the NEI Supersystem damaging or altering the immune response for their survival resulting in false positive and false negative food antibody test results.

In the Immune Compromised individual, the immune response the response will depend on their immune system status. This can be best measured by the Neuroscience Stimulated Cytokine panel. The Immune Status Scale (Fig. 2) is not measurable but represents a means to demonstrate the compromised immune system.

  • Zero is DEATH through an acquired immune deficiency and an incompetent immune system.
  • From zero to 30 denotes an ineffectual immune system activity characterized by extreme weakness with tremendous loss of any immune response in the body.
  • The point 30 denotes approaching death unless an immune response can be stimulated which will give it a higher potential ability to protect oneself.
  • From point 30 to 60, there is immune suppression with a decreasing ability to respond to immune challenges with symptoms of cytokine-induced sickness behavior.
  • Symptoms of cytokine-induced sickness behavior begin appear as the body nears 60. A competent immune system will be able to return the body to above 60.
  • From 60 to 100, we note complete health, with 100being the maximum quality of perfect being.
  • From 100 to 150, we note immune stimulation with symptoms of cytokine-induced sickness.
  • From 100 to 130, there is immune stimulation in response to immune challenges. A competent immune system will be able to return the body to below 100.
  • At 130, we will note symptoms of complete cytokine-induce sickness.
  • At rate 150– death takes place through Septic shock, Anaphylaxis, or Toxic Shock

The immune system can jump from the immune suppressed range to the immune stimulated range during a cytokine storm or when provoked and back again. The tissue producing the immune cells may fatigue contributing to a yo-yo effect of cytokine storms followed by a collapse of the immune response as the tissue recovers.

Cyrex vs Neuroscience
Cytokines that enhance cellular immune responses, Th1 (INf-γ, TNFα, etc.), Th2 (TGF-β, IL-4, IL-10, IL-13, etc.), Th17 (IL-17, Il-21, Il-22, IL-26, G-CSF, TNFα), and Th9 (Il-9) favor antibody responses. Cytokines binding to antibodies create a stronger immune effect.

Cytokine Storms

Cytokine storms may occur in both Immune Suppressed and Immune Stimulated. Chances are you have if you are suffering from Hashimoto’s, autoimmune conditions or a confusing mess of symptoms, you may be experiencing your very own Cytokine Storm season where you will have bad days followed by calm days after the storm and again by bad days. You may have found yourself in the proverbial “up a creek without a paddle” in your autoimmune world.

Cytokine Storms occur when the immune system becomes and remains activated against the immune stimulants beyond the point of being helpful.

Lectin Toxicity Evades Antibody-Based Blood Tests

While it is clear that lectins have the potential to do harm, it must be emphasized that the type of harm they do is harder to diagnose than in classically defined food allergies or sensitivites. In other words, confirmation of intolerance will not be found in antibody, allergy or intestinal biopsy testing because the damage done is a direct cytokine driven response, and not necessarily immune-medicated or only secondarily so.

The diagnostic “invisibility” is why lectin consumption is rarely linked to the ailments that afflict those who consume them. While lectins are not the sole or primary cause of a wide range of disorders, them are a major factor in sustaining or reinforcing injuries or diseases once they are initiated and/or established in the body.

Fig. 3:Stimulated Cytokine Test Results Base: General Overall Immune Response

Blue: Zero to 60– Immune Suppressed or Immunocompromised (Fig. 2)
Red: 100 to 150– Immune Activated or Stimulation (Fig. 2)

As you can see from the Stimulated Cytokine Test results that you can be Immune-Stimulated and Immune Suppressed simultaneously. You may experience symptoms of both a suppressed and stimulated immune system (see Fig. 2).

All had bad reactions with the Th1/TH2 challenge. Why? All have an overactive Th17 immune response. Three have a suppressed TH1 response. One has a suppressed TH2 response. The upper right is immunocompromised. The lower right is immune stimulated to everything. The lower left is a raw vegan over-consuming Soft and Hard Lectins. The upper left TH1 immune system collapses when exposed to bacteria driving straight into TH17.

You also have to apply some common sense. Common sense would tell you with autoimmune conditions your immune system isn’t working properly. Are you going to trust it to be accurate during a TH1/TH2 challenge? Lab testing is the best way to determine your immune status.

The TH1/TH2 Challenge does not recognize the TH17 response, immune suppression or stimulation.

In recent years, a specific T-cell subset, termed TH17. TH17 contributes to the development of diseases such as multiple autoimmune diseases including allergic inflammation, rheumatoid arthritis, autoimmune gastritis, inflammatory bowel disease, Hashimoto’s, psoriasis, and multiple sclerosis. The TH1/TH2 Challenge does not recognize the TH17 response, immune suppression of stimulation. Confusing results occur when different immune status responses are not accounted for as seen in Fig. 1.

Two Different Rheumatoid Arthritis Patients

It is much better to provoke an immune response in a laboratory setting than suffer the consequences of a failed TH1/TH2 challenge. The Neuroscience NEI Gold (5516) determines the baseline immune status and whether lectins (PHA) or bacteria (LPS) provoke a TH1, TH2 or TH17 response. As seen in Fig. 1 the immune system can fail when provoked (blue color) resulting in a suppressed immune system. Measurement of stimulated cytokines can identify the presence of an excited or suppressed immune status.

Are Edible Enemies contributing to poor health and inflammation? Lectins cause a plethora of damage to the body, promoting chronic inflammation and sensitivity. Take the Edible Enemy Quiz to test your knowledge on lectins.

Use the Lectin Control Formula to reduce the inflammatory response that occurs due to lectin consumption. Take two capsules with each meal.

Use Registration Code: DP283 to get access to the Doctor’s Supplements Store.

Get your “Autoimmune Diet Lectin Avoidance Guidelines” eBook

Click on this image to get your Autoimmune Diet Lectin Avoidance Guidelines eBook.

TH1

Th1-lymphocytes are primarily made in response to microbes that infect or activate macrophages and Natural Killer cells, and in response to viruses.

Th1-type cytokines tend to produce the proinflammatory responses responsible for killing intracellular parasites and for perpetuating autoimmune responses. Interferon gamma is the main Th1 cytokine. Excessive proinflammatory responses can lead to uncontrolled tissue damage, so there needs to be a mechanism to counteract this.

TH2

TH2-lymphocytes are primarily made in response to helminths (worms), allergens, and extracellular microbes and toxins. The TH2-type cytokines include interleukins 4, 5, and 13, which are associated with the promotion of IgE (severe allergies) and eosinophils response, and also interleukin-10, which has more of an anti-inflammatory response. In excess, TH2 responses will counteract the TH1 mediated microbial killing action. The optimal scenario would therefore seem to be that we should produce a well-balanced Th1 and Th2 response, suited to the immune challenge.

 

TH17

The purpose of Th17 cells is to clear pathogens, which are not efficiently handled by TH1 and TH2 type of immunity. The induction of Th17 responses must go through three distinct steps: Induction, amplification and stabilization. The stability of Th17 population is only relevant if it is protective against a given pathogen-invader or other kind of insult. If Th17 cells lose their stability they become highly proinflammatory and promote the destruction of your body’s tissues as occurs in autoimmune conditions. In essence, your immune system chooses to sacrifice body tissues by destroying in order to preserve the rest of your body.

TH17 and Vaccine-Related Injuries

Mercury or aluminum is put into vaccines to stimulate an immune response the contagious bacteria with the intention of developing immunity to the disease causing microbe. However, if a child is born with an over active TH17 response from the mother during pregnancy. A reaction, small or catastrophic may occur leaving the child impaired or worse. It is important to determine the immune status of the woman prior to or during pregnancy. Dr. Peterson can provide the answers to this.

TH17 is not included in the TH1/TH2 Challenge

The TH-1/TH-2 Challenge as noted in the book “Why Do I Still Have Thyroid Symptoms?” was printed prior to understanding of TH-17. The TH-1/TH-2 Challenge may provoke a TH-17 response. The TH-17 destroys tissue rather than allowing it to be inflamed; analogous to a suicide bomber attack that you can not defend against.

We can and do use laboratory testing to determine your autoimmune response. We recognize the impact of autoimmune conditions and the possibility of false positives and false negatives when using such labs. We start by using H.I.S.S.

  • History
  • Information
  • Signs
  • Symptoms

By utilizing a step-wise approach: Ask questions first. Lab test second. Immune challenges should be done in a laboratory – not your body. The physicians at Wellness Alternatives can determine the most likely scenario involving your immune system without provoking an uncontrolled immune response.

Very few are strictly TH-1 or TH-2.

Those with TH-1 dominance creating symptomatology usually feel better with coffee or caffeine. But feel worse with immune stimulators – Echinacea, goldenseal, immune-boosting mushrooms or probiotics. A person with TH-2 dominance creating symptomatology are the opposite. They will feel better with immune stimulators – Echinacea, goldenseal, immune-boosting mushrooms or probiotics and feel worse with coffee or caffeine.

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Very few are strictly TH-1 or TH-2. This leads to confusion and frustration when doing immune system challenges. More often than not a person will be both TH-1 and TH-2 with multiple autoimmune conditions, i.e. >80% with Hashimoto’s also have Autoimmune Gastrointestinal Disease. This happens when different autoimmune diseases are actively provoking both sides of the immune system to be overactive and the regulatory part of the immune system can’t regulate either side. When a person has both TH-1 and TH-2 creating symptomatology, they often come into the office saying: “I’m always sick” or “I’m allergic to everything.” When TH-1, they will feel worse with immune stimulators – Echinacea, goldenseal, immune boosting mushrooms or probiotics and feel better with little amounts of coffee or caffeine. Which causes a shift pushing them into an overactive TH-2 response were they will feel worse with coffee or caffeine but feels better with little amounts of immune stimulators – Echinacea, goldenseal, immune boosting mushrooms or probiotics.

This eventually drives them into a place where neither TH-1 nor TH-2 creates symptomatology but both are over reactive and under reactive at the same time. They will happily report, “I never get sick” in addition to “But I know I’m not well.” This is scary because their immune system is no longer able to protect them. They are slip sliding away down the slippery slope of autoimmune diseases because their immune system is too fatigued for any appropriate response. Those that add, “I feel good” are doing Green Allopathy often fall into this category. When we look at their labs they will have low absolute neutrophils (<1800) and lymphocytes (<1500). Some will have only one low – others both. Those with an underactive TH-2 will tell us they feel better with a little coffee, or caffeine but feel worse with moderate amounts of coffee, caffeine – as they are driven into TH-2 dominance. At the same time they also have an underactive TH-1 where they feel better with a little immune stimulators – Echinacea, goldenseal, immune boosting mushrooms or probiotics but feel worse after a time with moderate amounts of immune stimulators – being driven into TH-1 dominance.

Reregulating the immune system

Rather than supporting either the TH1 or TH2 while ignoring the TH17 dominance. Wellness Alternatives recommends Quieting the Immune system and doing everything we can to not provoke any immune response. Think of it as if you are being quiet after finally getting a cranky baby asleep. You don’t want to do anything to wake it up. In addition to this we support the T-Helper, T-regulatory cells and inhibitory neurotransmitters and cytokines to re-regulate the TH1, TH2 and TH17 immune response.

Now a quick jump back to the antibody story. It has been proposed that antibodies are normally inactive in a healthy individual. It has been said that 60% or more of the action of a healthy immune system is to deal with the leakage of larger food molecules from the gut. There is, after all, a high degree of similarity between various mammalian animal proteins in our diet and those found in our bodies. If our immune system were to attack all instances of these proteins, we would all have arthritis, lupus, and many other autoimmune diseases. Yet, in some people this type of antibody based damage does occur.

Calm & Quiet, Don’t Suppress or Stimulate Your Immune System

Taking supplements to stimulate one side because you did a TH-1/TH-2 challenge will only make both sides overactive. Yes, in theory taking supplements stimulating the TH-2 is supposed to control the TH-1 after immune regulation has been achieved. The reason you have an autoimmune disease is largely due to an inability to control your immune response. If the immune regulation was not working before the challenge, chances are very high, it will not work by provoking the other side.

It is ill-advised to provoke an immune system that cannot regulate.

Do not write checks your body cannot cash.

The physician at Wellness Alternatives utilize supplement protocols to quiet and re-regulate your immune system. This may involve supporting the regulatory or helper T Cells or the inhibitory cytokines and neurotransmitters. Care must be taken as noted previously as sometimes supporting the regulatory/helper T cells can provoke the inhibitory cytokines and neurotransmitters or vice versa into having an adverse response.

Find out WHAT is the root cause; what initial incident, infection, chronic or otherwise, is provoking and perpetuating this immunological alert status. Then deal with it!

  • DO whatever is necessary to QUIET, not suppress or stimulate, your immune system.
  • DO rotate your diet.
  • DO try to avoid many of the immune stressors in your environment.
  • KEEP a diary so you can LEARN what those stressor are! Start comparing them, you may find common ingredients, which are the provoking your immune system. This too, gives you more slack, as you can then use things without those ingredients.

For effective strategies to prevent immune-mediated disorders, including food allergy, it is essential to understand the external variables that influence immunological programming and how they interact with genetic predisposition to disease. Knowing that Autoimmune processes can be arrested if the interplay between genes and environmental triggers is prevented by re-establishing intestinal barrier function. The physicians at WA use the following 4 principles to re-establish the intestinal barrier function.

  • Restore the Gastrointestinal Barrier Variables
  • Restore the Gastrointestinal Digestive Sequencing
  • Restore the Gastrointestinal Terrain
  • Re-Regulate the Immune system
  • Re-Regulate the Neurotransmitter imbalance
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Are You Concerned with Bone Loss?

osteoporosis vs. normal boneOsteoporosis and bone loss is probably one of the most feared and misunderstood aspects in health care. Most think calcium is the main focus when it comes to bone loss. Healthcare authorities recommend taking calcium (usually from a cheap, poorly absorbable source) and everything will be okay. In doing so, the cause of bone loss is overlooked and the effects accepted as part of the “normal” aging process. But there is actually much more to maintaining healthy bones than calcium, weight-training, or bone drugs. And one connection that is often overlooked is reducing inflammation.

The “calcium is good for your bones” mantra is yet another example of a good theory gone wrong, and represents how broadly deluded the mainstream medical community is about bone health and the nature of osteoporosis, and its highly fabricated twin condition “osteopenia.”

There are actually a number of studies indicating that mass market calcium supplements increase other risks for other problems, while offering little benefit to your bones. When the level of calcium in the body fluids rises above normal, the nervous system is depressed and reflex activities of the central nervous system become sluggish. Also increased calcium ion concentration decreases the QT interval of the heart increasing the heart rate, and it causes constipation and lack of appetite, probably because of depressed contractility of the muscle walls of the gastrointestinal tract.

It is important to understand that the way the body works does not change to suit a current philosophy of a diseases cause and effect. Neurology, physiology and anatomy in the human body do not change. They have meaning and cannot be ignored or changed to suit a particular philosophy. By understanding the cause, you will understand the effect. Each rationalizes into a procedure that we hope will eliminate the cause of disease and alters the effect back to normal health.

When it comes to bone health, a body suffering from chronic inflammation can send messages that disrupt the natural remodeling process that our bones undergo on a regular basis. And for many, the unfortunate result after years of this simmering fire is brittle, osteoporotic bone.

The Value of Continual Remodeling of Bone

Inflammatory bone erosionThe continual deposition and absorption of bone has a number of physiologically important functions.

  1. Bone ordinarily adjusts its strength to the degree of bone stress. (Wolff’s Law) Bone thickens when subjected to heavy loads. (exercise)
  2. The shape of the bone can be rearranged for proper support of mechanical forces by deposition and absorption of bone in accordance to stress places upon the bone. (exercise vs. no exercise/sedentary lifestyle) (spinal curvatures and breaks)
  3. Old bone becomes relatively weak and brittle; new bone is needed as the old bone degenerates. Bone is alive and needs to be replaced just as other tissues of the body do. It takes about two years for bone to be 100% replaced.

Equilibrium between Bone Formation and Loss.

Osteoclasts and osteoblasts are instrumental in controlling the amount of bone tissue:

  • osteoblasts form bone.
  • osteoclasts reabsorb bone.

Osteoblasts are primarily responsible for turning osteoclast production and activity on and off. They do this via a system of signaling proteins called cytokines, i.e. c-Fos. The cytokine messengers in the inflammation–bone dynamic are essentially activators of osteoclasts, causing increased bone loss. When ongoing inflammation is present, more osteoclasts are generated and stay active longer than they should, disrupting the natural balance.

Think of osteoclasts as the building inspector / demolition crew. They constantly inspect the bone for signs of aging. When they find old bone, they tear it out so the remodeling crew (osteoblasts) can remodel the bone. Remodeling crews do not start remodeling until the demolition has been completed.

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Bone is continually being formed by osteoblasts where osteoclasts have been active, and it is continually being absorbed where osteoclasts are finding old bone needing to be replaced.  A small amount of osteoblastic activity occurs continually in all living bone (approximately 4 percent) so that at least some new bone is being formed constantly. Bone is being continually absorbed by osteoclasts (normally less than one percent in all living bone) at any given time.

Normally, except in growing bones (children), the rates of bone deposition and absorption are equal to each other, so the total mass of bone remains constant. Usually osteoclasts exist in small but concentrated masses; and once a mass of osteoclasts begins to develop, it usually eats away at the bone for about 3 weeks, eating out a tunnel. At the end of this time the osteoclasts disappear, and the tunnel is invaded by osteoblasts and new bone begins to develop. Bone deposition continues for several months. Bone loss medications such as “BONIVA are a nitrogen-containing bisphosphonate that inhibits osteoclast-mediated bone resorption” state this on their websites.

Now apply number three above to the statement and ask yourself what would happen if the osteoclasts bone inspector/demolition crew were made to stop their work? Well for one thing, calcium loss would stop. Hurrah!! Bone loss has stopped. WooHoo!! Does the bone stop aging? No, it continues to age and deteriorate. When the osteoblast remodeling crew finishes their current projects, they see no active tunnels so they stop working. Will this make the bone stronger, or with age, will the bone become weaker? Bone loss and aging still occurs even with these medications.

How does inflammation affect my bones?

When it comes to strong bones, our bodies rely on a dynamic coupling between the cells that break down old bone and those that build new bone. If the immune system is persistently activated, this process becomes uncoupled and the osteoclasts, the cells that break down bones, begin to run amok. Just as the inflammatory process is essential for healing the body, osteoclasts are essential for healthy bone turnover. But when there is imbalanced activity between osteoclasts and osteoblasts, the cells that build up bone, we begin to see more bone breakdown than building.

Cortisol – the stress hormone, is the leading contributor to bone loss. Elevated cortisol has a negative impact on bone metabolism. It lowers bone formation thus favoring development of osteoporosis in the long term. Know any one immune from stress? If you are constantly under stress, your cortisol level can remain elevated over long periods of time. Research now correlates chronically elevated levels of cortisol with blood sugar problems, fat accumulation, compromised immune function, exhaustion, bone loss, and even heart disease.

Cortisol also thins the lining of the stomach, decreasing the production of stomach acid. Did you know stomach acid is required to transport calcium into your body? This is why it is recommended to take a calcium supplement with some form of acid, i.e. calcium citrate. Apply a little common sense to this situation when your doctor tells you to take Tums antacids (calcium carbonate) for your calcium supplement, which further lowers stomach acid and makes less calcium available.

In a study appearing online in the February 2006 issue of the Journal of Clinical Investigation, Kyoji Ikeda and colleagues from the National Center for Geriatrics and Gerontology in Japan show that oral vitamin D treatment inhibits the production of the protein c-Fos.  As c-Fos plays a key role in the development of osteoclasts, which are the specialized cells responsible for bone breakdown and resorption, the authors also show that the vitamin D–mediated inhibition of c-Fos prevented bone loss through a suppression of osteoclast development.

Vitamin D also reduces the production of proinflammatory cytokines. These findings clarify how vitamin D helps limit bone resorption in conditions such as osteoporosis, and suggest that high dose oral Vitamin D is more effective than calcium supplements.  However, many in the healthcare community continue to say that Vitamin D only helps by supporting calcium absorption without looking at the impact elevated cortisol and inflammation have on calcium metabolism.

Many in the alternative healthcare community promote liver / gallbladder flushes and cleanses. They understand that poor liver function will impact your health. I find it ironic that at the same time recommend Vitamin D supplements that must pass through the liver to be emulsified prior to use. Taking a Vitamin D supplement may add more distress to the liver/gallbladder system by forcing it to work harder.  I recommend using a pre-emulsified Vitamin D available at Wellness Alternatives to by-pass the sluggish liver/gallbladder.

Long term, which do you think would be more effective in preventing bone loss: calcium supplements and/or a Boniva-type medication that only ineffectively addresses one area of concern, or treating the underlying cause that predisposes many of us to bone loss? Do what you can to reduce your stress levels. How often to you exercise? We can assist you with your bone loss concerns.  Call Wellness Alternatives today!

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Probiotics Maintain Autoimmunity

The Probiotic Paradoxis that both live and dead bacteria in probiotic products can generate biological responses. The use of probiotics in an unhealthy gut can result in immune dysregulation, bacterial translocation into the lymph and blood and increased inflammation. The Probiotic Paradoxis that the action of probiotics are dependent upon the health of the gastrointestinal tract, immune status and how established a disease process is.

According to a report, laboratory testing of 12 refrigerated and 8 non-refrigerated, randomly selected probiotic supplements obtained from different health food stores revealed that only one product contained the same bacteria as those listed on the label. Many of the refrigerated products had some beneficial bacteria, but contained fewer species of organisms than the label claimed. More than 30% of all supplements were contaminated with other microorganisms and 50% of the non-refrigerated products were completely dead.

The Probiotic Paradox

For a probiotic to work it must arrive alive. Probiotics promote gut health through stimulation, rather than suppression, of the innate immune system. The Probiotic Paradox is that both live and dead bacteria in probiotic products can generate biological responses. Dead probiotics only stimulate a TH1 response, which is also responsible for autoimmunity. Do not increase the TH1 immune response if you have or think you have an autoimmune condition. Probiotics will provoke the more severe autoimmune TH17 response.

Probiotic Survival

For a probiotic to work it must arrive alive. Probiotics promote gut health through stimulation, rather than suppression, of the innate immune system. Our first lines of defense are digestive chemistry and innate immunity.

Stomach acid and bile sterilize anything entering the gastrointestinal tract, if the stomach and gallbladder are healthy enough to do so. An unhealthy stomach and gallbladder may not be able to produce the quantity and quality of acid and bile needed to do the job. This is a duel edge sword. In a healthy gut, unprotected live probiotics will be killed. In an unhealthy gut, the live probiotics will survive but will change their behavior to better survive in an unhealthy gut environment and become pathogenic.

To increase survival probiotics not only should be refrigerated but acid proofed. Many companies do not use acid proofing. Others in an attempt to acid proof use calcium carbonate, an antacid. This neutralizes the sterilization effect of stomach acid and stimulation of the release of bile and pancreatic juices. Other companies use sodium alginate as an acid proofer for probiotics.  Sodium alginate is used as a form of bubble wrapping the microbes in which the sodium alginate serves two purposes: One is it’s a good acid proofer, and after the pancreatic juices are released. The pancreatic juice dissolves the sodium alginate, and then becomes food for the microbes.

Acid and Bile Proofed Probiotics

For a probiotic to work it must arrive alive in the colon. Probiotics defined as “live micro organisms” which, when administered in adequate amounts, confer a health benefit on the host” are common core materials that are often encapsulated in alginate gel. It has been recommended that food containing probiotic bacteria should contain at least 106live micro organisms per g or mL at the time of consumptionto have protective effects such as maintenance of normal intestinal micro flora, enhancement of the immune system, reduction of lactose intolerance and anti-cancer activity.

Along with that probiotics should resist the natural barrier of high acidity and bile content in the gastrointestinal tract (GIT) and show their survivability and activity in the colon. Since some Lactobacillus lack the ability to adequately survive gastrointestinal tract conditions micro-encapsulation techniques have been applied to improve acid, bile and heat tolerance of probiotics  and to inhibit unwanted reactions during storage and processing which can result in loss of survival and activity. Many probiotic brands report only the storage shelf life with no mention of gastric or intestinal survivability.

Most Probiotic companies print the strength (In Colony Forming Units, or, CFU) available at the time of manufacture, not at the time of expiration. This means they can be dead by the time they reach the store and they lived up to their guarantee. Probiotics are living organisms, and are perishable. They must be refrigerated if stored over 2 weeks. More important than sheer numbers is DELIVERY. Probiotics MUST have an acid proof delivery system to get the probiotics to the intestinal tract where they are needed.

Many probiotics are soil based. Soil based organisms are not naturally found in our bodies and aren’t as compatible. Human origin probiotics are. Another negative with soil based probiotics is that it’s hard to remove impurities and unwanted bacteria from soil based organisms. This can be a health issue for persons with impaired barrier variables (AKA “Leaky Gut”) since nonnative organisms can go systemic.

Probiotic supplements such as Theralac protect the contents of the capsule to ensure delivery of the contents into the intestines which is where they need to be. Only there can they be truly effective.

Probiotics needs protection from the gastrointestinal chemistry, and a growth stimulating food.

The gut environment is controlled by digestive chemistry. The digestive chemistry must occur in a specific sequence and order to maintain the gut environment. Border integrity must be maintained. Even probiotics should be contained within the gut and not allowed into the blood or other body parts.

No microbe can occupy a niche already occupied by another microbe, similar to Darwin’s finches on the Galapagos Islands. The fifteen finch species each developed feeding and structural changes to support their survival as a species. Microbes develop different attributes to support their survival.

Microbiome balances are naturally controlled through competitive exclusion. The use of probiotic supplements can create a situation similar to that being experienced in Australia in the gut. Cane toads were introduced Australia in 1935 to control the native cane beetle. Without any natural predators, the introduction of the toads has cause the depletion of native species. The toads find the Australian environment to be ideal for their survival. The environment can also limit invasive species such as boa constrictors in Florida. Cold weather limits their ability to move into northern Florida.

Gastrointestinal control of Predominant, Facultative, Obligate, Opportunistic, Yeast Mold, Parasites occurs through:

Stomach Acid: First line of defense from microbes

  • Stomach acid kills alkaline loving microbes
  • Chemical destruction through acidic pH
  • Barrier system

Pancreas juices and bile: Second line of defense from

  • Pancreas juices and Bile kills acid loving bacteria
  • Chemical destruction through alkaline pH
  • Barrier system

Probiotic Growth Stimulants

Probiotic Sources of Iron

Iron is highly controlled in the body because free iron produces massive amounts of free radicals. Iron is also an aphrodisiac for bacteria. If bacteria are to survive, they must get iron from their environment. Bacteria will actively seek out iron in red blood cells. Disease-causing bacteria do this in many ways, including releasing iron-binding molecules called siderophores and then reabsorbing them to recover iron, or scavenging iron from red blood cells, hemoglobin and transferrin.

To counteract this, the liver produces hepcidin (an immune system body guard for iron) in response to inflammatory cytokines and bacteria. Hepcidin levels can increase as the result of non-bacterial sources of inflammation, like viral infection, cancer, autoimmune diseases or other chronic diseases causing low iron levels. The sequestration of iron is a major defense mechanism against bacteria. Many mistake low iron levels as a need for iron rather than the body’s attempt to control microbial overgrowth.

  • Probiotics iron which provides a readily available iron source for all bacterial.
  • Lactoferrin binds iron and makes it difficult for iron dependent, gram negative bacteria (like Salmonella and E. coli) to grow. This gives gram positive, probiotic bacteria (which require less iron) a competitive advantage.

There are numerous bacteria species that have an affinity for iron. They will actively seek out and destroy blood cells causing anemia of chronic inflammation. Using iron as a probiotic growth stimulant will fuel bad bacteria overgrowth.

Fructooligosaccharides

Currently the prebiotic FOS is under fire for not being selective enough for probiotics since it stimulates non-probiotic bacteria such as Enterococcus species. This concern aside, a number of probiotic manufacturers still include FOS in their products. Virtually all of the data on FOS as a prebiotic shows a requirement of 4-8 grams per day. So picture this: If probiotic brand X contains 100 mg of FOS per capsule (a typical amount) – to get to the 4 gram minimum requirement you would have to take 40 capsules per day. So FOS there as label dressing in these products– as a marketing story.

There is a positive point to make on FOS: Natural sources of FOS – inulin – are present in certain foods such as bananas, onions, tomatoes, rye bread, asparagus and artichokes are beneficial and quite compatible with probiotics – these are examples of true prebiotic foods. The problematic FOS is the synthetic form. Be aware of inulin sensitivity when eating inulin containing foods.

Lactoferrin

Bacteria organized in biofilms are a common cause of relapsing or persistent infections. Lactoferrin (Lf), a major iron-binding protein induces intestinal lining growth where bacteria must attach to to colonize the colon, proliferation of probiotic bacteria, and depending on its concentration and affects the function and permeability of the intestinal mucosa. The bacterial endotoxin (lipopolysaccharide, LPS) is known to cause mucosal hyperpermeability. Lactoferrin has protective effects against LPS-mediated intestinal mucosal damage and impairment of barrier function in intestinal epithelial cells by reducing biofilm growth. Lactoferrin nearly abolished LPS-induced increases in mitochondrial free radical generation and the accumulation of oxidative damage in the DNA.

Acid Proofing Probiotics

Studies show that > 99% of unprotected probiotics are killed when exposed to stomach acid for 1 hour, a typical time spent in the stomach.

Brand X: (Bacillus coagulans, a probiotic bacteria), calcium (calcium carbonate), vegetarian capsule shell (hypromellose, water, titanium dioxide (color), chlorophyll), microcrystalline cellulose, magnesium stearate and silicon dioxide. May contain trace amounts of casein (milk protein). Lactose free.

  • None
  • Calcium carbonate
  • Acid neutralizer promote Hypochlorhydria, Gallbladder Insufficiency, Pancreas Insufficiency & Loss of Microbial controls
  • Sodium alginate used to acid-proof capsules is a natural carbohydrate found in seaweed protects Probiotic bacteria passage through stomach.

Call today! 530-615-4083

Enzymes indiscriminately damage immunoglobulins.
Bacteria, mold and parasites damage immunoglobulins to support their survival.

The simplified use of digestive supplements such as Betaine HCl or enzymes does not restore the gut environment. A person using these would digest food better but these supplements will also digest the unprotected gut lining and even cleave immunoglobulins. Immunoglobulins protect you and alert the immune system to potential problems. Cleaved immunoglobulins make you sensitive to anything that comes into contact with them, i.e. food, or cells from the body. Naturally produced digestive acid and enzymes are produced in a healthy gut lining. You may feel better using digestive supplements but you should ask why you need them. Wouldn’t it make more sense to determine the cause of the unhealthy lining? Then support the restoration of healthy gut lining.

Avoid Doses Of Probiotics And Prebiotics.

Until the gastrointestinal lining has had time to heal. The exception would be during antibiotic use which would be a good time to support with live acid-proofed probiotics. The live probiotics would have an opportunity to occupy the lining not damaged by lectins.

The time this takes will depend upon many different factors, i.e. your unique circumstances, diet, therapeutic supplements, immune status, microbial flora, etc. For a probiotic to work it must arrive alive and have a place on the gastrointestinal lining to attach to. Live probiotics colonize the gastrointestinal lining and the contents of the gastrointestinal tract. Dead probiotics only stimulate a cytokine immune response. Live probiotics must have a healthy thin mucus layer to attach to. Lectins damage multiple barrier variables causing shedding of the gastrointestinal villi leaving no space for live probiotics to attach to.

The adverse effects of lectins on gut physiology cannot be counteracted by probiotics.  Lectins alter the microbial flora and damage the gastrointestinal lining. At the same time, lectins stimulate a pro-inflammatory cytokine immune response. A healthy gut will be better equipped to support a balanced microbial flora and withstand the effects of inevitable but reasonable lectin intake.

I want the Lectin eBook

 

Are Edible Enemies contributing to poor health and inflammation? Lectins cause a plethora of damage to the body, promoting chronic inflammation and sensitivity. Take the Edible Enemy Quiz to test your knowledge on lectins.

Use the Lectin Control Formula to reduce the inflammatory response that occurs due to lectin consumption. Take two capsules with each meal.

When is it Appropriate to Introduce Probiotics? 

This is a good question. It will depend entirely upon your unique circumstances. We are just now beginning to look at the possibility that prebiotics and probiotic can have deleterious consequences. The Metametrix GIFX will provide important clues when it is appropriate to use live acid-proofed probiotics support. Gastrointestinal symptoms should be minimized and stable with regular bowel movements. Elastase1 should be mid-range and fecal pH should be near 6.6 - 6.8.

Consider these tried-and-true tips for better gut flora (no feces involved):

Eat fermented foods 

For their good taste—and your good health—favor living fermented foods like unpasteurized sauerkraut and quality yogurt or kefir. This is how they help keep you healthy.

  • Unprocessed fermented foods stimulate the immune system.
  • The flora in living cultured foods form a “living shield” that covers the small intestine’s inner lining and helps inhibit pathogenic organisms including E.coli, salmonella and an unhealthy overgrowth of Candida (yeast).
  • Some fermented foods create antioxidants (glutathione and superoxide dismustase) that scavenge free radicals which are a cancer precursor.
  • Fermenting transforms hard-to-digest lactose from milk to the more easily digested lactic acid. It neutralizes the anti-nutrients found in many foods including the phytic acid found in all grains and the trypsin-inhibitors in soy.
  • Fermentation generates new nutrients including omega-3 fatty acids, digestive aids and the trace mineral GTF chromium.

Eat more plants- Plants are packed with dietary fiber, which bacteria ferment and use to fight pathogens. Dietary fiber is food for bacteria.

Eat a variety of plants- You’ll improve the diversity and health of your microbiome at the same time.

Choose drug-free meats- We all need antibiotics sometimes, but try to reduce your exposure. Antibiotics kill bacteria without discriminating good from bad. A lot of livestock is fed antibiotics and that’s transferred to us.

Call today! 530-615-408

Using Thermography to Identify Thyroid Dysfunction

Over the years at our clinic, we have seen images of women with thyroid or Hashimoto’s using infrared thermography for breast health, in lieu of mammograms.

In almost all of the cases cases, we have clearly seen cases of inflammation in the dental area using this heat sensing technology. In all of those cases, a heat signature can be seen running from the area of oral infection down to the thyroid area.

Many of these cases are caused by a low-grade infection and inflammation and have, through further testing, been attributed to dental or oral issues, such as issues related to root-canal treated teeth. Invariably, some cases are very subtle, even asymptomatic for many years, but these cases slowly and continuously affect peoples’ health.

And she is mad at me because she spent $14,000 getting her amalgams removed.

With thermographic imaging, we can identify areas of suspected inflammation and infection because they present with heat. Once an area of concern is identified, it needs further investigation and resolution. People living with a chronic source of infection and inflammation will eventually find that their immunity is affected. This is because once the oral bacteria leave the mouth, they become invasive species and keystone pathogens.

In some cases, this chronic inflammation and invasive infection will actually promote the dysfunction of other organs in the body. Numerous studies have linked vaginosis (chronic yeast infections), miscarriages, pre-term birth, and gastrointestinal symptoms are linked to invasive oral bacteria.

The natural defense mechanism to fight development of organ dysfunction is impaired since their immune system is busy dealing with inflammation that has no chance of resolving on its own. In addition to this, the symptoms are far away from the mouth and people are using supplements or treatment for where the symptoms are occurring. The only way this problem can be resolved is by identifying and removing the cause. The infected area has to be properly dealt with before the body can be restored to health.

Conclusion

The IR imaging procedure provided enormous information about the physiological processes through examining the temperature of the body that can be related to the internal process of inflammation or irritation. The early signs provided by the IR imaging can be used as a prognostic indicator in detecting inflammation and subclinical pathology. The merits of a non-invasive IR imaging modality are important in identifying early stages of inflammation not visible by other imaging modalities. There is a high confirmation rate of ninety (90%) percent indicating strong correlation between thermographic and dental exams.

Oral Bacteria Damage the Thyroid

Those suffering from thyroid conditions may experience recurrent gum bleeding, easy bruising, and chronic fatigue. Hypothyroid patients have capillary blood supply alterations in gum tissues. Those suffering from thyroid issues also have enhanced periodontal bone loss as tooth-supporting alveolar bone is less sensitive to hormonal signals.

Oral Bacteria Damage the Thyroid

Oral Periogenic bacteria can cross into the blood stream through the bleeding gums causing a systemic inflammatory infection. The tissue of the gums can also become infected. This allows periodontal bacteria to enter into the blood stream, which translocate to organs of high metabolic activity, i.e. the Thyroid.

And she is mad at me because she spent $14,000 getting her amalgams removed.

If an oral bacterial infection is not able to establish drainage through the skin surface or into the oral cavity, it may spread diffusely through the neck’s soft tissue. Once the infection descends into the neck, it may reach the thyroid gland. The spread of the oral infection to the thyroid can cause thyrotoxic symptoms: temperature changes, pale skin, excessive sweating, tremors, tiredness, rapid heart beat. The swelling of the thyroid gland can cause trouble swallowing and speaking. Dental treatment would be required to stop the infectious drainage to the thyroid.

Oral bacteria causing infections in gum tissue may threaten more than your teeth and gums. Research has established associations between oral bacteria and systemic diseases including:

  • Chronic Inflammation
  • Autoimmune Diseases
  • Thyroid issues
  • Hair loss
  • Gastrointestinal disease
  • Degenerative Disc disease
  • Arthritis and Joint Pain
  • Type 2 Diabetes
  •  Heart Disease
  • Respiratory Disease
  • Blood Clots
  • Strokes
  • Preterm and Low Birth Weight Babies
  • Miscarriage
  • And many more.

The theories linking oral bacteria to other diseases explain that the mouth may be a portal for bacteria to spread to the rest of your body. These theories have been confirmed through the use of microbial DNA testing with an added wrinkle. There are more than just acid loving-cavity causing bacteria in the mouth.

Multiple Conditions – One Body

You are allowed to have more than one dysfunction occurring in your body at the same time. Too many Professional and Social Media Influencers promoting their version of low thyroid or Hashimoto’s make everything a result of thyroid dysfunction. In fact, some of the diseases occurring in the body, i.e. oral bacteria periodontitis contribute to thyroid symptoms.

Patients with long standing hypothyroidism may have increased subcutaneous mucopolysaccharides due to decrease in the degradation of these substances. The presence of excess subcutaneous mucopolysaccharides may decrease the ability of small blood vessels to constrict when damaged or cut and may result in increased bleeding from infiltrated tissues, including mucosa and skin.

Patients suffering from Hypothyroidism also have poor gingival microcirculation with a reduction in the diameter of capillaries, as well as a greater number and tortuosity of capillary loops.

The successful management of periodontal conditions is beneficial for the successful treatment of thyroid conditions. The length of time from periodontal disease onset to treatment of thyroid disorders may be critical, since uncontrolled periodontal disease resulting in destruction of the specialized tissues that both surround and support the teeth, maintaining them in the maxillary and mandibular bones.

After removal of thyroid due to cancer, a oral bacterial infection is seen by thermography. Radiating from the mouth to the thyroid area and into the gut. The micro-IDent and Metametrix GFP 2100 confirm the species of bacteria involved.
After removal of thyroid due to cancer, a oral bacterial infection is seen by thermography. Radiating from the mouth to the thyroid area and into the gut. The micro-IDent and Genova GIFX confirm the species of bacteria involved.

Oral Bacteria Translocation

Flossing, brushing or especially dental scaling can easily create bleeding. Many dentists claim this is normal and insignificant in terms of regular dentistry. If you experience oral bleeding you should be concerned, especially if you are suffering from an autoimmune condition. This opens a two-way street for blood to escape, and for bacteria to enter the blood stream. The blood stream provides access to all of the organs and tissues of the body while the bacteria (influenced by chemotaxis) looks for lodging.

Biting something hard like almonds, raw crunchy veggies or any hard food flushes these bacteria – if present – to the gingival crevice where they are liberated into the lymphatic drainage or into the blood circulation when chewing food or gum.If an infection is not able to establish drainage through the skin surface or into the oral cavity, it may spread diffusely through fascial planes of the neck’s soft tissue. Once the infection descends into the submandibular space, it may extend to the lateral pharyngeal space, and then to the retro-pharyngeal space. From here, it may reach the thyroid gland.

Dirt Tooth Powder

The damage caused to the gland results in the release of a conspicuous quantity of thyroid hormones, thus causing a thyrotoxic pattern: temperature, cutaneous pallor, excessive perspiration, tremor, tiredness, weight loss, increased appetite, and tachycardia.

Additionally, the thyroid gland’s edema caused difficulty swallowing (dysphagia) and speaking (dysphonia) commonly seen with thyroid gland enlargement. After dental treatment consisting of ultrasonic scaling, PerioProtect and appropriate anti-inflammatory and antibiotic therapy determined by dental PCR testing, administration of oral beta-blockers and corticosteroid therapy may be performed to counteract thyrotoxicosis in order to prevent recurrences. A root canal may be necessary, once the thyrotoxicosis had been resolved.

Simply using nutritional support for the thyroid will have no impact on oral bacteria induced damage to the thyroid. Call 530-615-4083 for more information.

What are the Effect of Dietary Lectins on Thyroid TSH Receptors

Lectins can attach themselves to Thyroid Stimulating Hormone (TSH) receptor sites and play havoc in two ways. The first is that the Lectins are able to “fit” the receptor sufficiently enough to stimulate the thyroid but the effects are different in those with hyperthyroid or Autoimmune Hyperthyroid and low thyroid or Hashimoto thyroiditis. The second effect is that the immune response to the lectin stimulation starts an autoimmune response to the thyroid stimulating hormone (TSH) receptorson the thyroid.

I want the Lectin eBookAutoimmune Diet Lectin Avoidance Guidelines
This 38 year old woman experience significant changes in her health by going on a Lectin Free Diet. The diet didn't stop the Cytokine Storms but significantly reduced their frequency.
I am 38 years old and throughout my life I have been to countless numbers of doctors dealing with digestion issues, parasites, migraines, allergies, blood sugar sensitivities, lack of energy, etc… By January 2013, my health had severely taken its toll, doctors given no explanation and I was barely able to walk by this point.  From what I believe is an absolute miracle, I came across an article from Wellness Alternatives.  I cannot thank you and your staff enough for saving my life and for getting my health back onto the road of recovery.  It has truly been a blessing to having met you.  I am absolutely amazed that through the blood work and quick turnaround analysis you were able to target the problem that I have had for years. Your knowledge,  professionalism and support throughout the past few months that I have met you has been truly inspirational.  I really am most grateful for what you have done for me and our family.
Sincerely, R. K.
Using the results from the Neuroscience Stimulated Cytokine Panel and NeuroEndocrine Comprehensive Panel, a protocol specifically designed for her has further reduced the occurrence of  the Cytokine Storms.

Call today! 530-615-4083

Are Edible Enemies contributing to poor health and inflammation? Lectins cause a plethora of damage to the body, promoting chronic inflammation and sensitivity. Take the Edible Enemy Quiz to test your knowledge on lectins.

Use the Lectin Control Formula to reduce the inflammatory response that occurs due to lectin consumption. Take two capsules with each meal.

Use Registration Code: DP283 to get access to the Doctor's Supplements Store.
I want the Lectin eBookAutoimmune Diet Lectin Avoidance Guidelines

What Are Lectin?

The production of lectins, alkaloids and secondary metabolites are a defense mechanism to protect themselves and their seeds from consumption while the plant is growing and before the seeds are ready for dispersal. For the purposes of this blog the listed secondary metabolites listed below will be referred to as Lectins unless specifically mentioned. Lectins occur naturally in organic and conventionally grown vegetables and fruit. Lectins occur artificially in Genetically Modified and Selectively Bred - organically or conventionally grown vegetables and fruits.

Plants are naturally genetically modified to survive in the primal environment of nature and are artificially genetically modified to survive their trip to the grocery store.

Plant Lectin Regulation of Vegetable & Fruit Consumption

Plants invest energy into the production of seeds. Plants have evolved to encourage vegetable and fruit seed dispersal but also evolved mechanisms to decrease consumption of vegetables and fruits when unripe and from non-seed dispersing predators. To this end, plants have developed physical and chemical deterrents.

Physical deterrents:

  • Cryptic coloration (e.g. green fruits blend in with the plant leaves)
  • Unpalatable textures (e.g. thick skins made of anti-nutritive substances)
  • Resins and saps (e.g. prevent animals from swallowing)
  • Repellent substances, hard outer coats, spines, thorns.

Chemical deterrents 

When immature or out-of-season, the seed, grain, vegetable or fruit are protected by chemical deterrents such as lectins to keep themselves from being eaten to extinction. Chemical deterrents in plants are called secondary metabolites, i.e.trypsin inhibitor, chymotrypsin inhibitor, α-amylase inhibitor, phytohemagluttinin (lectin), phytic acid, oxalic acid, nitrate and nitrite, L-mimosine, canavanine, L-DOPA, glucosinolates, cyanogenic glucosides/cyanogens, tannins, gossypol, chlorogenic acid, saponins, phorbol esters and alkaloids. 

Damage Caused By Lectins:

  • They bind to the thyroid TSH-receptorsacting as long-acting thyroid stimulator (LATS)stimulating the activation of TSH-receptor antibodies.
  • Lectins acting as LATS stimulate overproductionof thyroid hormones in those suffering from Hyperthyroid or Graves disease.
  • Lectins acting as LATS block productionof thyroid hormones in those suffering from low thyroid or Hashimoto’s thyroiditis.
  • Lectins are toxic to wounded cells and inhibit the natural repair system of the GI tract.
  • Lectins are known to “unlock” (breakthrough) the barrier variables of the GI lining and allow large undigested protein molecules into the bloodstream.
  • Lectins serve as a "Trojan horse" allowing intact or nearly intact foreign proteins to invade our barrier variables (natural gut defenses) and enter behind the lines causing damage well beyond the gut and into the joints, brain and skin of affected individuals provoking cytokine immune responses.
  • They can bind to red blood cells causing the cells to clump together resulting in a form of anemia.
  • They can damage collagen and connective tissues in joints.
  • They are directly related to Rheumatoid Arthritis.
  • They can bind to the stomach lining even when the pH is 3 or less.
  • They stimulate abnormal thickening of the pancreas interfering with exocrine cells production of enzymes and endocrine cells production of insulin.
  • They stimulate abnormal thickening of the lining of the gut.
  • They damage the villi lining the gut.
  • They stimulate the shift the microbial ecology promoting the overgrowth of E. coli.
  • The abnormal thickening of the pancreas and gut lining plus the microbial shift exacts a nutritional penalty on the absorption of nutrition.
  • They can provoke IgG and IgM antibodies causing Type 2 Hypersensitivity immune responses.
  • They provoke a direct cytokine driven immune response causing cytokine storms, invisible illness symptoms and cytokine-induced sickness behavior.

Effects of Dietary Lectins on the Thyroid

Lectins can attach themselves to a thyroid receptor site and play havoc in two ways. The first is that the Lectins are able to "fit" the receptor sufficiently enough to stimulate the thyroid but not enough fit sufficiently to produce thyroid hormones. The second effect is that the immune response to the lectin stimulation starts an autoimmune response to the thyroid.

Concerned about your Thyroid?

Thyroid stimulating hormone (TSH) at various concentrations significantly increased the response of lymphocytes to both lectins found in legumes and in other vegetables and fruit. Lectins may cause the activation of ‘long-acting thyroid stimulator (LATS)’also known as thyroid stimulating immunoglobulins, or TSI, in the blood.  TSI or LATS are antibodies that bind to special receptors on the thyroid gland than normally bind to thyroid stimulating hormone (TSH). TSH is the hormone that stimulates the thyroid gland to secrete thyroid hormones.  TSIs mimic the effect of TSH, thereby causing the thyroid to secrete excessthyroid hormone. LATS mimic the effect of TSH only stimulating the thyroid but not producing any thyroid hormones.

Lectins act as Long-Acting Thyroid Stimulators (LATS) and cause the activation of Thyroid Stimulating Hormone Receptor Antibodies (TSH-R Ab). These LATS appear to act similarly to TSH after attaching to the TSH receptor. The LATS are able to "fit" the receptor sufficiently well to stimulate the thyroid while blocking the production of thyroid hormones. This activates the immune system to produce TSH-R Ab to the thyroid stimulating hormone receptors. TSH-R Ab Autoantibodies act as thyroid stimulator agonist in autoimmune hyperthyroid (Graves disease) mimicking the effects of TSH and causes the overproduction of thyroid hormones with hyperthyroid symptoms. TSH-R Ab act as TSH antagonist in autoimmune hypothyroidism (Hashimoto thyroiditis) causing an inverse reaction blocking the production of thyroid hormones making it seem as if the individual is suffering from a low thyroid.

For those with low thyroid, their TSH levels will be low but the thyroid is being stimulated resulting in swelling, tenderness and irritation to the thyroid. Those who have Hashimoto’s, hyperthyroid or Grave’s disease the TSH-R antibody will stimulate the production of TPO antibodies resulting in an immune attack on the thyroid causing further destruction. This is often the case for those with elevated TPO antibodies who are doing all the right things but still have high TPO Ab.

Lectin excited T cells, which produce immunoglobulin excited thyroid function, causing hyperthyroidism. Although pituitary TSH release is suppressed, thyroid-stimulating antibodies not subject to negative feedback maintain the hyperthyroidism. These antibodies appear to act similarly to TSH and via the TSH receptor.

Lectin Exposure  Symptoms

Symptoms could be obvious, such as gas, bloating, diarrhea, or constipation (or both, alternating). Less obvious food related symptoms may include headache, fatigue, 'indigestion,’ skin problems including hives, psoriasis, acne, swollen joints, or water retention. While some symptoms will resolve quickly after eliminating an offending family, other symptoms may take 6-12 months. Be patient. If you are genetically intolerant, you will never be able to consume that group of foods safely.

Some symptoms may occur chronically and may seem unrelated to a gut/food or lectin intolerance reactions. This group of symptoms includes the so-called degenerative diseases and autoimmune diseases like those mentioned in the list at the beginning of this report including ‘Invisible Illness,’ Cytokine-Induced Sickness Behavior, atherosclerosis, hypertension, osteoporosis, senile dementia, osteoarthritis and Rheumatoid Arthritis, inflammatory joint diseases, fibromyalgia, chronic fatigue, and adult onset diabetes. Obesity has been associated with consumption of 'edible enemy' lectins.

Are Edible Enemies contributing to poor health and inflammation? Lectins cause a plethora of damage to the body, promoting chronic inflammation and sensitivity. Take the Edible Enemy Quiz to test your knowledge on lectins.

Use the Lectin Control Formula to reduce the inflammatory response that occurs due to lectin consumption. Take two capsules with each meal.

I want the Lectin eBookAutoimmune Diet Lectin Avoidance Guidelines
Use Registration Code: DP283 to get access to the Doctor's Supplements Store.

Lectin Toxicity Evades Antibody-Based Blood Tests

The type of harm lectins do is harder to diagnose than in classically defined food allergies or sensitivities. In other words, confirmation of intolerance will not be found in IgA, IgG, IgE antibody, allergy or intestinal biopsy testing because the damage done is a direct cytokine driven response, and not necessarily immune-medicated or only secondarily so. Intestinal biopsy testing may be suspect because lectins cause a thickening of the intestinal lining. The medical community is looking for thinning and damage to the intestinal lining.

The diagnostic “invisibility” is why lectin consumption is rarely linked to the ailments that afflict those who consume them. While lectins are not the sole or primary cause of a wide range of disorders, them are a major factor in sustaining or reinforcing injuries or diseases once they are initiated and/or established in the body. This response will deplete your anti-inflammatory cytokines and inhibitory neurotransmitters. Many will suffer cytokine storms during flair-ups. Some will develop into an invisible illness known as Cytokine-Induce Sickness Behavior.

Once lectins make it through a compromised mucosa and/or digestive lining. It can exert systemic effects which can easily become overlooked as being caused by eating legumes, fruits or vegetables. The best tests to determine how lectins are affecting your cytokine immune status and neurotransmitter levels are the:

  • Neuroscience Stimulated Cytokine Analysis Comprehensive
  • Neuroscience NeuroEndocrine Comprehensive
Base: General Overall Immune Response
PHA (Lectin): Immune Response when exposed to Lectins
LPS (Bacteria): Immune Response when exposed to Bacteria
Blue: Immune Suppressed or Immunocompromised
Red: Immune Activated or Stimulation

Four Different Hashimoto Patients - Four Different Immune Responses

All had bad reactions with the Th1/TH2 challenge. Why? All suffered a lectin driven immune response. All have an overactive Th17 immune response. Three have a suppressed TH1 response. One has a suppressed TH2 response. The upper right is immunocompromised. The lower right is immune stimulated to everything. The lower left is a raw vegan over-consuming Soft and Hard Lectins. The upper left TH1 immune system collapses when exposed to bacteria driving straight into TH17.

Systemic Effect of Lectins 

Lectins may influence absorption, metabolism and systemic availability of nutrition by two different but possibly simultaneous mechanisms.

Lectins can indirectly influence hormones (the endocrine system of the body) by binding to the neuroendocrine cells of the gut and as a consequence of this input, release message molecules (hormones) to the blood. Alternatively, lectins can pass through the gut wall into the blood circulation and thus may directly influence peripheral tissues and body metabolism by mimicking the effects of endocrine hormones. The organs most often affected are the pancreas, skeletal muscle, liver, kidneys and thymus.

Thymus, spleen and other organs: Overconsumption of Soft Lectins causes the thymus and spleen to begin decreasing in size wasting away. Some of these are irreversible with potentially serious consequences for the immune system, especially T cell-mediated immunity.

Effects of Dietary Lectins on Inflammatory Cytokines

Cytokines are several different types of substances that are produced by cells within the immune system. These substances relay signals between the immune system cells. By relaying messages between the cells, these cytokines help to trigger the immune system’s response to whatever threat is present.

Lectins strikingly increase levels of multiple pro-inflammatory cytokines (especially interleukin 2 receptor (IL-2), tumor necrosis factor alpha (TNF-α), IL-6, IL-8).

Cytokines, (mediators of acute inflammation) are generated to induce cell breakdown and death. Cytokines can produce an inflammatory response to food independent of the allergic reaction that most are familiar with.  Food allergy or cross-reactive testing will not detect a cytokine induced inflammatory response to food. This requires specialized testing done with the NEI Stimulated Cytokine panel that measures these cytokine and chemokines.

A phenomenon involving the function of inflammatory cytokines is known as a cytokine storm. Essentially, this is a situation where the balance of communication between immune cells and the cytokines present is interrupted.

When the inflammatory cytokines are involved in some sort of storm situation, there is a loopback created between both types of cytokines and the immune cells. The pro-inflammatory cytokines go wild – like college students on Spring Break. There are several common signs that indicate that a storm is present, including fever, body aches and nausea, along with stronger symptoms that are related directly to the ailment itself. Similar to how the college student feels after a week long binge that does not wear off.

Immune Supportive Supplements

A person is said to be immunocompromised when their immune system is incapable of working at full capacity. The immune system is how the body fights off diseases and protects itself against new infections, so someone who is immunocompromised will usually get sick more often, stay sick longer, and be more vulnerable to different types of infections. They may be more inclined to use supplements to stimulate the immune system. Until they become immune suppressed. Then they rarely get “sick.” Immunosuppressed individuals never feel well and start developing symptoms associated with Cytokine Induced Sickness Behavior (CISB).

Information from secondary sources suggests that supplementing with immune stimulating supplements, i.e. thymus gland extracts, have been shown to enhance responsiveness to Lectins and have been able to produce an cytokine storm in immunocompromised patients.

Lectins: Edible Enemies

Being realistic regarding diet is that there is always a sliding scale of lesser evils that we exchange for the experience of enjoying our foods and obtaining the comfort they provide. Because some food toxins cannot be removed from foods and other may be created during processing or cooking, consumption of small quantities of food toxins is unavoidable.

How problematic or reactive lectins are for you depends upon the health of your gastrointestinal lining, the behavior of your microflora and your immune status. If you have a Ghetto Gutwhere the gut lining is impaired, the microbes are misbehaving, and your ability to produce digestive chemistry is less than optimal. Any food you commonly eat will provoke a reaction including organic foods. This combination of factors will change your immune status depleting the inhibitory neurotransmitters and anti-inflammatory cytokines necessary to control the Neuro-Endo-Immune Super-system. When it comes to the immune response, small insignificant changes in lectin exposure can mean the difference between being reactive or not.

The Autoimmune Diet Lectin Avoidance Guidelines will reduce your exposure to lectins, GMOs. The Seasonal - Four Day Rotation diet will add variety to your diet while reducing your risk of creating food sensitivities.

Your chances of eating your way out of this will be significantly increased by following these guidelines. You will still need help re-regulating your neurotransmitters, cytokines and restoring the sequencing of your digestive tract.

Are Edible Enemies contributing to poor health and inflammation? Lectins cause a plethora of damage to the body, promoting chronic inflammation and sensitivity. Take the Edible Enemy Quiz to test your knowledge on lectins.

Use the Lectin Control Formula to reduce the inflammatory response that occurs due to lectin consumption. Take two capsules with each meal.

I want the Lectin eBookAutoimmune Diet Lectin Avoidance Guidelines
Use Registration Code: DP283 to get access to the Doctor's Supplements Store.

Iodine and the Thyroid: Part 2 Iodine vs. Antibody Testing

In the post: Iodine and the Thyroid: Part 1, I stated that the proponents of iodine will quote studies supporting iodine use but start stammering and yammering like they have a swollen tongue (probably due to their iodine deficiency) when asked about the studies reporting autoimmune thyroid caused by iodine.

This post attracted responses by iodine proponents validating the point of my blog. Iodine proponents never mention any link between iodine and autoimmune thyroid or do any lab testing looking for autoimmune thyroid induced by iodine supplementation.

Concerned about your Health?
Iodine toxicity questions- Call today! 530-615-4083

Ironically the source of this response, a Laboratory Associate from a well-known lab could not have known that a patient brought in Iodine level reports from this lab last week. The lab results provided by this lab are good. I use them every time a patient brings them but I will not use their treatment recommendations for reasons you will see below.

“Hello Dr Peterson, 

I just finished reading your blog post about iodine and I have a couple of questions. 

First, my iodine related background. 

  • Developed an iodine test in dried urine that is now in production and used to detect dietary iodine deficiency.
  • Read through over 600 complete publications on iodine, the thyroid, and halides
  • Aware of both sides of the iodine supplementation argument (high and low dose)
  • Constantly following iodine blogs, forums, twitter etc.
  • Talked with many doctors, over the phone and at conferences, about their experience with iodine supplementation
  • Recently published a paper on Japanese iodine intake and the health of the Japanese people 
  • Completed a study on the iodine-loading test to determine why so many individuals fail and how a 50mg dose is excreted
  • Investigated whether iodine or other halides cause the side effects seen in those who take large amounts of iodine 

As I read through your blog post, I picked up that you were against high dosing of iodine, yet you mention supplementing with proper amounts when needed. 

For both an “iodine sufficient” (in this case, at least 150ug/day) and an “iodine deficient” individual, what dosing do you recommend? Do you see any benefits from supplementation with iodine or iodide outside of thyroid hormone production?”

I have to admit in Iodine and the Thyroid, I omitted their fall back excuse for recommending iodine – “Ya-but Japanese people eat kelp and kelp has iodine.” As you can read in the proponents email, there is no mention of autoimmunity. But admits to being aware of both sides of iodine supplementation – “high and low dose”. I didn’t see any mention of iodine dosage causing autoimmune thyroid. How do you read “over 600” complete publications and not find any mention of autoimmunity?

I will use the recommendations from this particular lab to answer this question. As you can see below, starting in July 2011 this patient was taking 50 mg of oral iodine/iodide for her “iodine deficiency”. She felt better for the first 30 days but soon after that began experiencing a severe decline in her health. Clumps of hair were falling out; fatigue, depression and when she reported this to her doctor ordered an iodine test. Her levels of iodine were 61,132. The normal range for iodine is 100-1,100 with the optimal being 150-300. If my math is correct that is 203 times the optimal level. When she questioned her iodine levels the doctor refused to take her call.

In addition to the iodine test, a blood test was done which included thyroid antibodies using the AtheNA methodology with ranges different from the microsomal antibody test. The older microsomal antibody test ranges for thyroid peroxidase antibodies are 0 – 34. The AtheNA ranges are a new methodology for measuring Thyroid Antibodies. These include thyroglobulin antibody and thyroid peroxidase antibody, which is a more specific test measuring the active antigen in the older microsomal antibody test.

As you can see this patient with 203 times the recommended levels using the “low dose” iodine supplementation has Thyroglobulin antibody levels of 192. This would be considered positive for Autoimmune Hashimoto’s thyroiditis, based on the strongly positive Thyroglobulin antibodies. This lab assistant and doctor fell into the Green Allopathy mind trap of “If I recommend it – it can do no harm.”

Thyroglobulin and thyroid peroxidase antibodies are most typically associated with Hashimoto’s thyroiditis or Graves’ disease, but can also be found in myxedema, granulomatous thyroiditis, nontoxic nodular goiter, thyroid carcinoma, and rarely in some other conditions.

Since her doctor wouldn’t answer her questions she sought out a different opinion and found my office. Unfortunately this is not an isolated incident. Women and men come into my office with similar stories every week. They feel better initially and then fall apart. Some continue taking iodine because their doctor says it is good for them. While others stop it as this woman did when she could not get the answers she sought.

She started feeling better stopping the iodine but after an autoimmune response is stimulated it can continue for six months or more. The autoimmune attack doesn’t stop but continues with the signs and symptoms less noticeable. Damage to your body is still occurring.

After triaging her case, a protocol was designed to re-regulate her immune system to reduce the autoimmune attack on her body and support restoration of the metabolic processes contributing to her condition.

Autoimmune disease is a serious health condition that should not be taken lightly. I don’t remember being told of the link between iodine and autoimmune thyroid while in school. But once I was told of the link I immediately stopped recommending iodine inappropriately. If your healthcare provider isn’t aware of the connection, you should inform them. If they ignore the connection you have to ask yourself what you want to do. Are you willing to risk your health because they dismiss the connection between iodine supplements and autoimmune thyroid?

If you decide to continue taking iodine, I wish you the best. For those that want to take iodine and work with our office, you will be dismissed as our patient. If you are confused in need of help, we can help answer your questions and develop a program to get you feeling better.

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Iodine for the Thyroid?

The debate regarding iodine and the thyroid is more polarized than that of democrats and republicans within the healthcare community. With each side is very adept at supporting their view with numerous studies, it becomes very confusing as to whether iodine is good or bad. Sometimes during the debate they claim expertise. It is interesting to compare their knowledge to reality. To see what happens when their recommendations are compared to lab testing. Iodine and the Thyroid: Part 2 Iodine vs. Antibody Testing

My decision is based on two events that occurred in my life. While attending chiropractic college, we were told iodine was necessary for proper thyroid function, therefore use iodine for hypothyroid. As a result of this I recommended the iodine patch test to treat thyroid patients. One woman I made this recommendation to seemed to respond well intitially. I say initially because she returned six months later looking in horrible shape. Eyes protruding, almost bald, 30 pounds heavier complaining of constant fatigue. What happened? I noticed a brown spot on her arm and thought it was an old bruise. She replied, she had just applied her iodine and it had not absorbed in yet. When asked why she had continued the iodine, she said she felt so good on it in the beginning, she decided to stay on it. She had been on the web and self-diagnosed herself with Candida attributing that to her current state of health. I decided then and there to never recommend iodine again until I understood what had happened.

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The second incident involved my own health. At the same time I recommended her use of iodine, I was using progesterone. Why, because a well known book recommended progesterone for men. Shortly after this I attended Dr. Kharrazian’s Functional Endocrinology course. Imagine my horror as he described what happens to those using progesterone inappropriately, which coincidentaly was how I was feeling. In addition to this, he described what occurs with inappropriate use of iodine, with shouting erupting from three doctors saying they have used iodine for 30 years of collective practice and not once had there been any ill effects. After the shouting subsided, Dr. K calmly said he would not debate the issue in that venue and asked them to order TPO antibody tests on all of their patients using iodine. Then next year he would discuss iodine with them. The following year, the three were again sitting together and as Dr. K brought up the iodine topic I turned to view their response. All three were shaking their head in unison agreeing with Dr. K.

“No battle plan survives contact with the enemy”

All nutritional or hormonal theories are based upon optimal body function through the vitalistic view where the nutrient or hormones interact in a perfect environment. Treatment plans for iodine and hormones are made based upon optimal function in a perfect environment. Who among us has optimal body function in a perfect environment, with disease and inflammation as are our enemies?

When your plan meets your enemies in the real world, the real world wins. Nothing goes as planned. Errors pile up. Mistaken suppositions come back to bite you. The most brilliant plan loses touch with reality. However, the reliance on these treatment plans, especially with the incongruence between plan and reality is usually an exercise in self-delusion. When plans meet the real world, it’s not the real world that will yield to your plan. You must adapt whatever you’re doing to the circumstances truly at hand. This is where Functional Medicine shines.

Before the 1920s, iodine deficiency was common in the Great Lakes, Appalachian, and Northwestern U.S. regions and in most of Canada. Treatment of iodine deficiency by the introduction of iodized salt has eliminated the “goiter belt” in these areas. To this day, iodine deficiency is almost none existant with the introduction of iodized salt. But the notion of iodine deficiency carries on today.

Iodine you may know is one of the most important minerals for proper functioning of the thryoid. Iodine is an essential element that enables the thyroid gland to produce thyroid hormones. The plan is then extrapolated by iodine proponents into iodine makes the thyroid work better therefore use iodine supplementation. While in reality, iodine, which is high up on the atomic scale requires near perfect pH for its assimilation into the body. But, the thyroid doesn’t get access to iodine unless the body pH is near perfect in addition to many other factors.

Why Do People Feel Better on Iodine?

If you are hyperthyroid you will feel better through the Wolff-Chaikoff effect. The Wolff-Chaikoff1-8 effect is used to describe hypothyroidism caused by ingestion of a large amount of iodine. Hyperthyroidism is the term for overactive tissue within the thyroid gland causing an overproduction of thyroid hormones (thyroxine or “T4” and/or triiodothyronine or “T3”).

It is an autoregulatory phenomenon which inhibits formation of thyroid hormones inside of the thyroid follicle. This becomes evident secondary to elevated levels of circulating iodide. Wolff-Chaikoff effect lasts several days (around 10 days), after which it is followed by an “escape phenomenon”, which is described by resumption of normal organification of iodine and normal thyroid peroxidase function. High levels of intracellular iodide are known to suppress the transcription of thyroid peroxidase (TPO) enzyme, along with NADPH oxidase. The suppresion of the enzymes that attach iodide to thyroglobulin causes a reduction in the production of the downstream product, thyroxin (T4).

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Wolff-Chaikoff is observed in individuals without an obvious thyroid disorder, and especially in patients with autoimmune thyroiditis or those previously treated for thyroid diseases (Graves’ disease, subacute or pospartum thyroiditis, iatrogenic thyroid dysfunction.)

 The hypothyroidism is transient and thyroid function returns to normal in 2 to 3 weeks if  iodine usage is withdrawn, but transient T4 replacement therapy may be required in some patients. The patients who develop transient iodine-induced hypothyroidism must be followed long term thereafter because many will develop permanent primary hypothyroidism. Continued use of iodine supplementation will cause the Jod-Basedow phenomenon to occur.

If you are hypthyroid, iodine usage increases thyroid production of T4. The thyroid gland actively takes up iodine and incorporates iodine into thyroid hormone. This provokes the thyroid into hyperfunction with out any feedback control. Think of it like putting your car in cruise control and never touching the brakes. Long term use of iodine then drives a person into the Jod-Basedow phenomenon AKA Iodine-Induced Thyrotoxicosis.

Jod-Basedow9-19 phenomenon, a thyrotoxic condition caused by exposure to increased amounts of iodine, has historically been reported in regions deficient in iodine. However, when a person is given iodine supplements combined with dietary intake on a continual basis without monitoring, they develop a hyperfunction autoimmune response. It causes an increased activity of TPO antibodies that multiply dramatically with iodine supplements.

IODINE SKIN PATCH TEST

In addition to driving a person first into a Wolff-Chaikoff effect, then into a Jod-Basedow phenomenon and eventually into iodine-induced autoimmune disease. The iodine supplementation or the skin patch test will not in any way show a person what their TPO antibodies are and will be different for each person due to different rates of absorption and elimination.

IT IS TIME FOR A REALITY CHECK!

Knowing we don’t have an optimally functioning body in an imperfect environment, the rules for normal don’t apply. The urinary clearance tests are only as good as their liver is able to detoxify. This makes iodine clearance testing suspect.

The proponents of iodine will quote studies supporting iodine use but start stammering and yammering like they have a swollen tongue (probably due to their iodine deficiency) when asked about the studies reporting autoimmune thyroid caused by iodine. I have to question why iodine proponents discredit testing for thyroid antibodies. I think an autoimmune disease takes precedence over an alleged deficiency. To paraphrase the Lay’s Chip ad, “You can’t have just one autoimmunity.” Wouldn’t you want to know?

The other side is not anti-iodine but pro-proper use. There are cases where a person is found to be Primary Hypothyroid through lab testing, where limited supplementation of iodine is recommended. Hashimoto’s disease is the most common cause of hypothyroidism in the United States. Hashimoto’s disease is an autoimmune disorder in which your immune system inappropriately attacks your thyroid gland, causing damage to your thyroid cells and upsetting the balance of chemical reactions in your body. The inflammation caused by Hashimoto’s disease, also known as chronic lymphocytic thyroiditis, often leads to an underactive thyroid gland (hypothyroidism).

Most people who have Hashimoto’s thyroiditis never actually develop overactive thyroid symptoms. Over time they start to develop the symptoms of low thyroid function and have their TSH measured. Their TSH will usually be found to be high and they are typically diagnosed as primary hypothyroid and placed on thyroid hormone replacement.

The issue of their autoimmune attack is not addressed. Instead, the medical community considers your thyroid condition managed by having a normalized TSH from thyroid hormone replacement. While the alternative and iodine proponents consider it managed by iodine supplementation. At least the medical community is using lab testing.

You decide whether you want someone managing your health were everything is an iodine deficiency or someone who looks for the true underlying cause of your health condition.

Read More: Iodine and the Thyroid: Part 2 Iodine vs. Antibody Testing

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  1. Markou K, Georgopoulos N, Kyriazopoulou V, Vagenakis AG.,  Iodine-Induced hypothyroidism. Thyroid. 2001 May;11(5):501-10.
  2. Lesher JL Jr, Fitch MH, Dunlap DB., Subclinical hypothyroidism during potassium iodide therapy for lymphocutaneous sporotrichosis. Cutis. 1994 Mar;53(3):128-30.
  3. Wémeau JL.,  [Hypothyroidism related to excess iodine], Presse Med. 2002 Oct 26;31(35):1670-5.
  4. Eng PH, Cardona GR, Previti MC, Chin WW, Braverman LE.,  Regulation of the sodium iodide symporter by iodide in FRTL-5 cells. Eur J Endocrinol. 2001 Feb;144(2):139-44.
  5. Alexandrides T, Georgopoulos N, Yarmenitis S, Vagenakis AG., Increased sensitivity to the inhibitory effect of excess iodide on thyroid function in patients with beta-thalassemia major and iron overload and the subsequent development of hypothyroidism. Eur J Endocrinol. 2000 Sep;143(3):319-25.
  6. Bando Y, Ushiogi Y, Okafuji K, Toya D, Tanaka N, Miura S., Non-autoimmune primary hypothyroidism in diabetic and non-diabetic chronic renal dysfunction. Exp Clin Endocrinol Diabetes. 2002 Nov;110(8):408-15.
  7. Frey H. Hypofunction of the Thyroid Gland, due to Prolonged and  Excessive Intake of  Potassium Iodide. Acta Endocrinol (Copenh). 1964 Sep;47:105-20.
  8. Reinhardt W, Luster M, Rudorff KH, Heckmann C, Petrasch S, Lederbogen S, Haase R, Saller B, Reiners C, Reinwein D, Mann K.  Effect of small doses of iodine on thyroid function in patients with Hashimoto’s thyroiditis residing in an area of mild iodine deficiency. Eur J Endocrinol. 1998 Jul;139(1):23-8.
  9. El-Shirbiny AM, Stavrou SS, Dnistrian A, Sonenberg M, Larson SM, Divgi CR. Jod-Basedow syndrome following oral iodine and radioiodinated-antibody administration. J Nucl Med. 1997 Nov;38(11):1816-7. Erratum in: J Nucl Med 1998 Mar;39(3):489.
  10. Navarro FA. [Jod-Basedow phenomenon: who was Dr. Jod?] Rev Clin Esp. 1997 Jul;197(7):531. Spanish.
  11. Goday-Arnó A, García Rico A, Martínez-Riquelme A, Cano-Pérez JF. [Graves Basedow disease following treatment with magistral formulae for obesity. Jod-Basedow phenomenon?] Rev Clin Esp. 1996 Aug;196(8):536-8.
  12. Gómez de la Torre R, Enguix Armada A, García L, Otero J. [Thyroid nodule disease in a previously endemic goiter area] An Med Interna. 1993 Oct;10(10):487-9. Spanish.
  13. Yamada T. [Jod-Basedow (iodine-induced hyperthyroidism)] Ryoikibetsu Shokogun Shirizu. 1993;(1):367-9. Review. Japanese.
  14. Woeber KA. Iodine and thyroid disease. Med Clin North Am. 1991 Jan;75(1):169-78.
  15. Maberly GF, Corcoran JM, Eastman CJ. The effect of iodized oil on goitre size, thyroid function and the development of the Jod Basedow phenomenon. Clin Endocrinol (Oxf). 1982 Sep;17(3):253-9.
  16. Maberly GF, Eastman CJ, Corcoran JM. Effect of iodination of a village water-supply on goitre size and thyroid function. Lancet. 1981 Dec 5;2(8258):1270-2.
  17. Livadas DP, Koutras DA, Souvatzoglou A, Beckers C. The toxic effect of small iodine supplements in patients with autonomous thyroid nodules. Clin Endocrinol (Oxf). 1977 Aug;7(2):121-7.
  18. Birkhäuser M, Burer T, Busset R, Burger A. Diagnosis of hyperthyroidism when serum-thyroxine alone is raised. Lancet. 1977 Jul 9;2(8028):53-6.
  19. Spaulding SW, Burrow GN, Ramey JN, Donabedian RK. Effect of increased iodide intake on thyroid function in subjects on chronic lithium therapy. Acta Endocrinol (Copenh). 1977 Feb;84(2):290-6.

Autoimmune Diet Lectin Avoidance Guidelines

When immature or out-of-season, the seed, grain, vegetable or fruit are protected by chemical deterrents such as lectins to keep themselves from being eaten to extinction. Chemical deterrents in plants are called secondary metabolites, i.e.trypsin inhibitor, chymotrypsin inhibitor, α-amylase inhibitor, phytohemagluttinin (lectin), phytic acid, oxalic acid, nitrate and nitrite, L-mimosine, canavanine, L-DOPA, glucosinolates, cyanogenic glucosides/cyanogens, tannins, gossypol, chlorogenic acid, saponins, phorbol esters and alkaloids. The production of lectins, alkaloids and secondary metabolites are a defense mechanism to protect them from consumption while the plant is growing and before the seeds are ready for dispersal.

Are Edible Enemies contributing to poor health and inflammation? Lectins cause a plethora of damage to the body, promoting chronic inflammation and sensitivity. Take the Edible Enemy Quiz to test your knowledge on lectins.

Use the Lectin Control Formula to reduce the inflammatory response that occurs due to lectin consumption. Take two capsules with each meal.

Use Registration Code: DP283 to get access to the Doctor’s Supplements Store.

Get your “Autoimmune Diet Lectin Avoidance Guidelines” eBook

Click on this image to get your Autoimmune Diet Lectin Avoidance Guidelines eBook.

Lectins inhibit the natural repair system of the GI tract, potentially leaving the rest of the body open to the impact of errant, wandering (i.e. unwanted) material from the digestive system.  Perhaps the most insidious impacts lectins can leave in their wake is leaky gut. Leaky gut is a term used for the breach of the Barrier Variables of the intestinal lining produced by lectins moving hand in hand with other physical/environmental triggers and other anti-nutrients. Once the intestinal breach occurs, lectins and other particles (like partially digested food, toxins, etc.) can “leak” into the bloodstream and provoke an inflammatory cytokine response throughout the body. Lectins cause much more than Leaky Gut.

Damage Caused By Lectins:

  • Lectins are toxic to wounded cells and inhibit the natural repair system of the GI tract.
  • Lectins are known to “unlock” (breakthrough) the barrier variables of the GI lining and allow large undigested protein molecules into the bloodstream.
  • Lectins serve as a “Trojan horse” allowing intact or nearly intact foreign proteins to invade our barrier variables (natural gut defenses) and enter behind the lines causing damage well beyond the gut and into the joints, brain and skin of affected individuals provoking cytokine immune responses.
  • They can bind to red blood cells causing the cells to clump together resulting in a form of anemia.
  • They can damage collagen and connective tissues in joints.
  • They are directly related to Rheumatoid Arthritis.
  • They can bind to the stomach lining even when the pH is 3 or less.
  • They stimulate abnormal thickening of the pancreas interfering with exocrine cells production of enzymes and endocrine cells production of insulin.
  • They stimulate abnormal thickening of the lining of the gut.
  • They damage the villi lining the gut.
  • They stimulate the shift the microbial ecology promoting the overgrowth of E. coli.
  • The abnormal thickening of the pancreas and gut lining plus the microbial shift exacts a nutritional penalty on the absorption of nutrition.
  • They can provoke IgG and IgM antibodies causing Type 2 Hypersensitivity immune responses.
  • They bind to the thyroid TSH-receptors acting as long-acting thyroid stimulator (LATS) stimulating the activation of TSH-receptor antibodies.
  • They provoke a direct cytokine driven immune response causing cytokine storms, invisible illness symptoms and cytokine-induced sickness behavior.

The most common source of lectins is from plants.  They are present in seeds to protect the seeds from those who eats the plant or seed-containing fruit.  The second most common source of lectins is seafood.  Virtually all known plants contain lectins, usually as one of a number of proteins in seeds, but often also distributed amongst the other parts of plants including leaves, roots, tubers and bulbs.

Plants are naturally genetically modified to survive in the primal environment of nature and are artificially genetically modified to survive their trip to the grocery store.

Plant regulation of Fruit Consumption

Plants invest energy into the production of fruits. Plants have evolved to encourage fruit eaters to consume their fruit for seed dispersal but also evolved mechanisms to decrease consumption of fruits when unripe and from non-seed dispersing predators. Plants have physical and chemical adaptations.

Physical deterrents:

  • Cryptic coloration (e.g. green fruits blend in with the plant leaves)
  • Unpalatable textures (e.g. thick skins made of anti-nutritive substances)
  • Resins and saps (e.g. prevent animals from swallowing)
  • Repellent substances, hard outer coats, spines, thorns.

A seed is mostly food (starch, protein, fat) for the plant embryo that will grow from it.  This is also true of a chicken egg and just like the egg, the seed contains defensive proteins to inhibit the growth of bacteria, fungi and egg/seed eaters.  The egg has enzymes to degrade bacterial walls and proteins that bind iron, vitamins, etc. needed by bacteria and humans.  Eating many raw eggs can lead to vitamin deficiencies.  Boiling the eggs unravels the defensive proteins and makes them digestible and nutritious.

Plant lectins (phytohemagglutinins or hemagglutinins) have been shown to possess a remarkable array of biological activities.  Lectins ihibit the natural repair system of the GI tract, potentially leaving the rest of the body open to the impact of errant, wandering (i.e. unwanted) material from the digestive system. This is especially true when these lectins “unlock” barriers to entry and allow larger undigested protein molecules into the bloodstream.

Seeds block being digested by containing proteins that foul the digestion system of would be devourers.  Plants are naturally genetically modified to survive in the primal environment of nature and are artificially genetically modified to survive their trip to the grocery store.

Lectins Helps Seeds Survive Being Eaten

Seed dispersal is important for plants because it allows their progeny to move away from their parents in space and time. The advantages of seed dispersal may have led to the evolution of fleshy fruits, which entice animals to eat the fruits and move the plants seeds from place to place. While many fruit producing plant species would not disperse far without being consumed because they can usually germinate even if they fall to the ground directly below the parent plant.

In order for plants to protect themselves from natural predators, their seeds naturally contain a variety of very smart chemicals – lectins – which have the potential to disrupt the health of unsuspecting humans.  Lectins work at the cellular level by disrupting cellular metabolism.  Plant seeds are designed for survival in nature not a trip through the grocery store.  A single seed must have multiple lectins to survive being eaten and survive the trip from mouth to tail, i.e. chewing, digestive enzymes, gut bacteria and fermentation and finally transit through the colon.

Are Edible Enemies contributing to poor health and inflammation? Lectins cause a plethora of damage to the body, promoting chronic inflammation and sensitivity. Take the Edible Enemy Quiz to test your knowledge on lectins.

Use the Lectin Control Formula to reduce the inflammatory response that occurs due to lectin consumption. Take two capsules with each meal.

Use Registration Code: DP283 to get access to the Doctor’s Supplements Store.

Get your “Autoimmune Diet Lectin Avoidance Guidelines” eBook

Click on this image to get your Autoimmune Diet Lectin Avoidance Guidelines eBook.

This is done by a combination of a hard digestion-resistant hull and enzyme-resistant lectins covering the seed. Then after passing through the gut resist bacteria, fungi, insects, and worms surviving the heat generated during fermentation and the cold of winter or the heat of summer until it is time to germinate. Each requiring a different protective lectin.

Some seeds are activated by digestive enzymes, i.e. cedar tree berries, just as fire activates certain pine seeds. Lectin pine coneThese  pine trees, including Monterey Pine and Pond Pine,  are only able to reproduce if a fire destroys them. Their pine cones, which contain the seeds, are so tightly held in the cone. That the seed cannot be released to germinate unless a fire burns away the outer part of the cone. These are called “fire climax pines”. Seeds cannot germinate to form new trees until the parent trees have been destroyed in a forest fire, assuring that the new trees will not have to struggle in darkness among adult trees, but will only be among trees of the same age. When there is a fire, the number of seeds released is great enough to assure survival of enough new trees to reforest the area. Fire climax pines are able to maintain their presence against the incursion of other species of trees because fire destroys all of the adult trees, but only the pines are naturally replanted.

Wild bird are active consumers of all berries, fruits and nuts. Seeds falling directly under the plant or tree would have to compete with the parent tree for sunlight, water, and nutrition.

Seeds that fall to the ground, may find themselves lying under a pile – no pun intended – of their mother plants or other foliage as they wait for next spring to germinate. This leads to the growth of spoilage microbes, generating heat. Hot spots developing under the pile can be extremely hot (130-150oF). The more certain elements in the foliage a plant has at the end of the growing season, i.e. Legumes, beans, lentils, etc. The more likely this is to occur. The seeds must be able to survive heat for long periods of time. This makes them resistant to heat from cooking.

Growing up on the farm, I have seen fermenting forage spontaneously combust. In order to protect themselves from this danger, seeds have naturally developed a high tolerance to heat.  Making them resistant to the quick cooking methods used today providing high levels of hard lectins to those thinking they are eating a healthy diet.

Raw and relatively unprocessed foods are becoming more fashionable among health-conscious individuals in the Western world. Given the abundance of food in prosperous countries, such persons are therefore most likely exposed to greater doses of dietary lectins than at any time in human evolution. Ingesting lectins can cause flatulence. Consuming legumes and grains in their raw form can even result in nausea, diarrhea and vomiting. Lectins consumed raw or unprocessed are at their most toxic potential.

 

Grains

Grains, beans, nuts and seeds are all seeds. Rich in complex carbohydrates and fiber, they form the base of most healthy food pyramids. Grinding them whole is purported to make them healthier. When ground with the hulls removed makes them a dangerous refined flour to be avoided.

      • Grains, beans, nuts and seeds are all seeds.
      • Grains are the seeds of grasses, e.g. Wheat, corn, oats, and rice.
      • Grains are small, hard, dry seeds (with or without attached hulls or fruit layers).
      • Beans are the seeds of legumes, e.g. Peas, lentils, soybeans, and chickpeas.
      • Nuts are the seeds of trees, e.g. Walnuts, hazelnuts, almonds, cashews.
      • Seeds are the seeds of plants, e.g. Sesame seeds, poppy seeds and sunflower seeds.
Translation: Brown rice in high in fiber that prevents absorption of nutrients while resisting digestion and promoting damage from lectins. It is not what you eat but what you absorb that counts.

Lectins when consumed at low levels are slightly irritating, but when eaten in moderate quantities become more damaging.