Are You Sensitive to Vitamin D?

Are you getting enough Vitamin D? 

For people who are outside daily for about fifteen minutes they ought to be fine. Since those with lives keeping them inside buildings, cars, stores, they received little sunlight. In addition, those of us who live in northern areas don’t get enough sun to affect our vitamin D production due to the angle of the sun in winter.

For those with an Autoimmune Condition, the story is quite different. Even short exposure to sunlight can provoke a Cytokine Storm. When I was at my worst. I could not walk out to get the mail in the sunlight. Fortunately, this condition has been resolved for six years.

Many can have an adverse reaction to Vitamin D, although the dosage they are taking is within the range that is supposed to be well tolerated according to studies. As you know Vitamin D is reported to do no evil. 

Vitamin D Receptor (VDR) Dysregulation

The conventional view of autoimmune disease is that it results from the adaptive immune system “gone awry,” leading to inflammation and destruction of human tissue. Consequently, the Medical community uses immunosuppressive agents frequently used to curb what is considered to be inappropriate immune activation. Alternative and Functional Medicine practitioners have taken the opposite approach of stimulating the immune system.  

Especially if microbes are involved. One of the agents proposed for this purpose is vitamin D. The use of vitamin D in various forms has had particular appeal because of a lower level of the precursor form 25-hydroxyvitamin D (25-D) often being associated with autoimmune disease.  This inverse association has fostered the view that adding vitamin D is correcting a deficiency. 

The new model discussed here is based on a different view of vitamin D and autoimmune disease. Vitamin D is a close resemblance in structure to immunosuppressive steroids. The levels of each of the vitamin D metabolites are affected by a complex network of feedback mechanisms involving multiple enzymes and receptors, indicating vitamin D is regulated more like a steroid than a nutrient. A low level of serum 25-D is seen as a deficiency rather than the result of down regulation and a causal factor leading to illness.

Certain bacteria species reported on the Genova 2200 Gastrointestinal Function Profile are the primary cause of Vitamin D Receptor dysfunction. The innate immune responses are the first line of defense against invading microbes and bacteria. Because VDR is key to the innate immune response, bacteria have developed ways to counter to activation of the Vitamin D Receptor reducing the immune response towards themselves.  VDR dysfunction would lead to chronic infections with a wide range of bacteria and other microbes, leading to inflammation and frequent elevation in autoimmune disease markers. 

When bacterial species convert bile salts into toxic bile salts. Toxic secondary bile acid levels are damaging to the cells lining the small intestine and cause extensive mucosal damage of the stomach and esophagus. This is more harmful than acid reflux alone. The major conversion of secondary bile salts is the formation of lithocholic acid. Lithocholic acid competitively inhibits etiocholanolone elimination occurring in the liver. This results in increase potential for immune stimulation and a localized fever. In addition to this lithocholic acid causes damage to Vitamin D receptors and reactions to sunlight or Vitamin D supplements.

The ability of certain bacteria to cause VDR dysfunction is believed to be key. Increasing evidence indicates that vitamin D supplementation can contribute to bacteria-induced dysfunction of the VDR. This VDR dysfunction leads to immunosuppression that, while palliative in the short term, is counterproductive for long-term healing.

Vitamin D Receptor Antibodies

Another possible explanation for vitamin D deficiency in patients with autoimmune diseases is the presence of neutralizing autoantibodies to vitamin D. Bacteria survive by confusing the immune system. When immune cells show up to access the damage like Police responding to a 911 call, being unable to see the bacteria, associate the damage with Vitamin D. The Immune Cells then mistakenly produce antibodies to Vitamin D and Vitamin D receptors. 

When this occurs, even exposure to sunlight can provoke an autoimmune response to Vit. D. Supplementing with Vit. D or even exposure to sunlight would provoke a Cytokine Storm with symptoms of Cytokine-Induced Sickness. Many with an impaired immune response may experience a mild form of Sun Poisoning. 

Sun Poisoning

Sun poisoning doesn’t really mean you’ve been poisoned. It is often the term used for a severe case of sunburn. This is usually a burn from ultraviolet (UV) radiation that inflames your skin. However, those with an autoimmune condition can experience Sun Poisoning through the activation of the immune cells to the Vitamin D being produced in the skin. This results in a person experiencing the symptoms of Cytokine-Induced Sickness

Symptoms of Sun Poisoning

Within just 15 minutes of being in the sun, you can be sunburned. But you might not know it right away. The redness and discomfort might not show up for a few hours.

You can become severely sunburned if you stay in the sun a long time and don’t wear protection. You are more likely to sunburn if you have light skin and fair hair.

Severe sunburn or sun poisoning can cause symptoms such as the following:

  • Skin redness and blistering
  • Pain and tingling
  • Swelling
  • Headache
  • Fever and chills
  • Nausea
  • Dizziness
  • Dehydration

Symptoms of a Cytokine Storm

The primary symptoms of a Cytokine Storm are:

  • Extreme fatigue
  • Low mood
  • Anxiousness
  • Anxiety
  • Insomnia
  • High fever
  • Intermittent Hot Flashes
  • Swelling and redness
  • Nausea.

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