Bone Marrow Fatigue

Do you have low white blood cells?  Are you always feeling bad and constantly fatigued but never get “sick”? If this is you?  You may have Bone Marrow Fatigue.

Do you have hip or sciatic pain the goes away for a couple of days after a Chiropractic adjustment? But then comes back again. You may have Bone Marrow Edema.

Bone Marrow Fatigue

When you have a low blood count, this means your bone marrow is not making enough of one type of blood cells. Bone marrow is a sponge-like tissue inside the bones. It contains stem cells that develop into the three types of blood cells that the body needs:

  • Red blood cells carry oxygen throughout your body.
  • White blood cells fight infections.
  • Platelets stop bleeding.

It has long been known that cells that make red blood cells make up the bone marrow. However, knowledge that immune response begins within the bone marrow, in other words, that bone marrow is also a secondary lymphatic organ, is fairly recent. Under normal circumstances, various cells form within the bone marrow, including endothelial precursor cells (EPC), neutrophils (Nf) and dendritic cells (DC).

Chronic Inflammation

Inflammation is part of the healing process for wounds and infections. Inflammation is a normal immune system response that functions to protect the body from infection and diseases. During inflammation, white blood cells and other body chemicals attempt to remove any potentially harmful substances from the body.

The body is set up for short sharp bursts of inflammation, to combat microbial, mechanical or chemical insults. This inflammation happens locally at the site of injury, but is guided by the autonomic nervous system and the Neuro-Endo-Immune Supersystem. The whole point is to generate enough inflammation to combat the threat through (stimulatory neurotransmitters, inflammatory cytokines & chemokines, white blood cells and the sympathetic nervous system) and then cool, repair and close up the area of injury ending the inflammation through (inhibitory neurotransmitters, anti-inflammatory cytokines and chemokines, white blood cells and the parasympathetic nervous system).

Disruption of the NEI Supersystem through long-term stress and the ingestion of inappropriate foods and chemicals irritation create a state of chronic inflammation. Our immune system can become fatigued, working at a low level, no longer able to generate enough energy for full protection, but still causing on going cell damage through low-grade inflammation. We become both depleted of certain white blood cells and others continue to maintain the inflammation.

The following are the most common symptoms of bone marrow fatigue. However, each person may experience symptoms differently. Symptoms may include:

LOW PLATELETS:

  • Easy bruising
  • Bleeding: nose bleeds, gums, or mouth
  • Tiny red spots on the skin (petechiae)
  • Blood in the urine
  • Dark or black bowel movements

LOW WHITE BLOOD CELLS:

  • Fever and chills
  • Rash
  • Diarrhea
  • Signs of infection (anywhere in the body):
  • Swelling
  • Redness
  • An area that is warm to touch

LOW RED BLOOD CELLS:

  • Fatigue
  • Paleness of skin, lips, and nail beds
  • Increased heart rate
  • Tires easily with exertion
  • Dizziness
  • Shortness of breath

Myelodysplastic Syndrome (MDS)

The myelodysplastic syndromes (MDS) are all disorders of the stem cell in the bone marrow responsible for producing blood cells. In MDS, blood production of Red and White Blood Cells is disorderly and ineffective. The number and quality of blood-forming cells decline, sometimes irreversibly, further impairing blood cell production.

What are the symptoms of Bone Marrow Fatigue and MDS?

Symptoms vary depending on the individual and the severity and time the bone marrow has been overworked. Symptoms may include:

  • Tiredness, or fatigue
  • Weakness
  • Excessive bleeding
  • Pinpoint red spots on the skin caused by bleeding from small blood vessels
  • Easy bruising
  • Frequent infections
  • Fevers
  • Pale skin
  • Shortness of breath

Compare these symptoms to your diagnosis of choice – Thyroid, Fibromyalgia, Lyme, etc. All of these symptoms would be diagnostic of those conditions without question.

Lower risk myelodysplastic syndromes (MDSs) are characterized by increased apoptosis of hematopoietic cells in the bone marrow (BM). The mechanism driving this excessive apoptosis involves multiple immune molecules, including inflammatory cytokines such as interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α) and interleukins (ILs). Interleukin-17 (IL-17) is the hallmark cytokine produced by CD4(+) Th17 cells, and IL-17 mediates activation of the adaptive T-cell response inducing an inflammatory cytokine environment. Elevated IL-17 levels and IL-17-induced IFN-γ and TNF-α overproduction may be involved in the pathogenesis of lower risk MDS. Bone broth stimulates production of IL-17.

Opposing memes of Medical vs. Alternative / Functional Practitioners.

The Medical Communitysuppresses the immune system with stronger and stronger drugs, i.e. LDN, hydrocortisone, etc.

Alternative and Functional Practitionersbelieve the autoimmune reaction occurs because the tissue is so toxic that the immune system basically can’t tell the good guys from the bad guys. It then starts attacking the tissues where the toxins are pooled.

Both Communities believe the immune system is working perfectly except that it cannot tell healthy tissue from bad tissue; bad bugs from good bugs, etc.

The Alternative and Functional Practitionerstreat patients with immune stimulating supplements and say, “You are going through a ‘Herx’ or ‘Flair.’ You will have more and more good days, less bad days. Stick with it.” “The flare-ups won’t be as bad or last as long.” This all makes perfect sense when they say it. Plus numerous websites say the same thing, so it must be true. They treat going through a ‘Herx’ or a ‘Flair’ as a rite of passage. I did this myself.  They claim – Don’t be afraid to stimulate the lymph, stimulate the immune system. It is the only way to heal these diseases.

Both of these memes will see initial success. After a three months the immune system will break free of the suppression or become so fatigued from the constant stimulation it will not be able to respond. Exaggerated response occur with administering more drugs or explained away as a ‘Herx’ or ‘Flair.’

Overstimulation of the Immune System

It is possibly to have an over active immune system, in very simple terms that is what is happening when you have an autoimmune disease. Autoimmunity is an ‘out of control’immune response. Honestly the entire idea of “boosting the immune system” is an invention of the supplement industry designed to sell products that practitioners capitalize on. It is validated by the ‘Common Cold.” Boost the immune system and it lasts seven days. Without immune stimulators it last a week. Okay the symptoms are less using immune stimulants. I’ve done that myself. It’s a great scam because both sick and healthy people think they need it.

This has then been extrapolated to any disease. Boosting the immune system will heal any disease in theory. They blindly follow this meme of immune stimulation. When in reality, more harm than good is being done. Everything is based on symptoms. Eventually with constant immune stimulation using supplements, bone broth, etc. The bone marrow producing the immune cells becomes so fatigued that quality and quantity of blood cells is impaired. The character of the immune cells behavior is changed. They want the immune system always on the hunt, always looking for something to do. Antibodies from previous exposure are deemed current infection. Why don’t the antibodies go away? They are memory cells from previous exposure not from an active infection.

Bone Marrow Fatigue is characterized by increased damage and/or death of hematopoietic cells in the bone marrow (BM). Here is where the miracle of immune-stimulation occurs. Inflammation is caused by an immune response. Without immune cells, inflammation is reduced. Based on reduced symptomatology or the lack thereof, this is a success until it is not. They crash the immune system by overstimulation, claiming success even though the patient has not improved overall.

Elegance in Healing

It was during the time when I was one of five Doctors across the United States given carte’ blanc immune lab testing that I realized the ‘Herx’ and/or ‘Flair’ is a Cytokine Storm with Th17 leading the charge. The cytokine storm have captured little attention of the public and the healthcare community alike, and while the general notion of an excessive or uncontrolled release of proinflammatory cytokines is well known in research, the concept of a cytokine storm and the biological consequences of cytokine overproduction are not clearly defined or recognized. Read More…

When the immune system is fighting pathogens, cytokines signal immune cells such as T-cells and macrophages to travel to the site of infection. In addition, cytokines activate those cells, stimulating them to produce more cytokines. Normally, this feedback loop is kept in check by the body. However, in some instances, the reaction becomes uncontrolled, and too many immune cells are activated in a single place. Bone Broth is loaded with cytokines signalling the immune system to respond in the overproduction of immune cells and attracting the immune cells to the location of the bone broth. Thus, promoting gut inflammation. Someone that is immune suppressed will feel better, temporarily. Then the blame is shifted to food sensitivities because ‘bone broth’ is healthy and could not possibly do any harm.

The cytokine storm is caused by an exaggerated response when the immune system encounters a new and highly pathogenic invader or a ‘false flag’ by immune stimulating foods and supplements. Cytokine storms have potential to do significant damage to body tissues and organs.

Healing must be elegant, working with the body’s own natural healing momentum and capabilities.

Cytokine Storm Treatment

The clinical presentations of all cytokine storm symptoms (CSS) can be strikingly similar, creating diagnostic uncertainty. However, clinicians should avoid the temptation to treat all CSS equally, because the triggers inciting inflammatory responses vary widely. It it thought that failure to identify and address this underlying trigger(s) results in delayed, nonoptimal, or potentially harmful consequences. However, chasing triggers is futile until the immune system is calmed and quieted. More often than not, calming and quieting the immune system eliminates the majority of the so called triggers.

You are a unique individual with your own set of circumstances. Stop trying to find a diagnosis box to stuff yourself into. You need help and I can provide assistance in sorting your system out. Call today 530-615-4083.

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